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Article: Genetic overlap between episodic memory deficits and schizophrenia: Results from the Maudsley Twin Study

TitleGenetic overlap between episodic memory deficits and schizophrenia: Results from the Maudsley Twin Study
Authors
KeywordsEndophenotype
memory
neurocognition
schizophrenia
twins
Issue Date2011
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSM
Citation
Psychological Medicine, 2011, v. 41 n. 3, p. 521-532 How to Cite?
AbstractBackground Visual and verbal episodic memory deficits are putative endophenotypes for schizophrenia; however, the extent of any genetic overlap of these with schizophrenia is unclear. In this study, we set out to quantify the genetic and environmental contributions to variance in visual and verbal memory performance, and to quantify their genetic relationship with schizophrenia.Method We applied bivariate genetic modelling to 280 twins in a classic twin study design, including monozygotic (MZ) and dizygotic (DZ) pairs concordant and discordant for schizophrenia, and healthy control twins. We assessed episodic memory using subtests of the Wechsler Memory Scale -Revised (WMS-R).Results Genetic influences (i.e. heritability) contributed significantly to variance in immediate recall of both verbal memory and visual learning, and the delayed recall of verbal and visual memory. Liability to schizophrenia was associated with memory impairment, with evidence of significant phenotypic correlations between all episodic memory measures and schizophrenia. Genetic factors were the main source of the phenotypic correlations for immediate recall of visual learning material; both immediate and delayed recall of verbal memory; and delayed recall of visual memory that, for example, shared genetic variance with schizophrenia, which accounted for 88% of the phenotypic correlation (rph=0.41) between the two.Conclusions Verbal memory and visual learning and memory are moderately heritable, share a genetic overlap with schizophrenia and are valid endophenotypes for the condition. The inclusion of these endophenotypes in genetic association studies may improve the power to detect susceptibility genes for schizophrenia. © 2010 Cambridge University Press.
Persistent Identifierhttp://hdl.handle.net/10722/141820
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID
Funding AgencyGrant Number
European Community through Marie Curie Training Network called the European Twin Study Network on Schizophrenia
NARSAD
Wellcome Trust064971
Economic and Social Research Council/Medical Research CouncilPTA-037-27-0002
Psychiatry Research Trust
National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health
Maudsley NHS Foundation Trust
Institute of Psychiatry, King's College London
Funding Information:

This work was supported by the European Community's Sixth Framework Programme through a Marie Curie Training Network called the European Twin Study Network on Schizophrenia, NARSAD (through a Young Investigator Award to Dr Toulopoulou), grant 064971 from the Wellcome Trust, grant PTA-037-27-0002 from the Economic and Social Research Council/Medical Research Council, and the Psychiatry Research Trust. We acknowledge support from the National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health award to the South London and Maudsley NHS Foundation Trust and the Institute of Psychiatry, King's College London.

References

 

DC FieldValueLanguage
dc.contributor.authorOwens, SFen_HK
dc.contributor.authorPicchioni, MMen_HK
dc.contributor.authorRijsdijk, FVen_HK
dc.contributor.authorStahl, Den_HK
dc.contributor.authorVassos, Een_HK
dc.contributor.authorRodger, AKen_HK
dc.contributor.authorCollier, DAen_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.date.accessioned2011-09-27T03:02:35Z-
dc.date.available2011-09-27T03:02:35Z-
dc.date.issued2011en_HK
dc.identifier.citationPsychological Medicine, 2011, v. 41 n. 3, p. 521-532en_HK
dc.identifier.issn0033-2917en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141820-
dc.description.abstractBackground Visual and verbal episodic memory deficits are putative endophenotypes for schizophrenia; however, the extent of any genetic overlap of these with schizophrenia is unclear. In this study, we set out to quantify the genetic and environmental contributions to variance in visual and verbal memory performance, and to quantify their genetic relationship with schizophrenia.Method We applied bivariate genetic modelling to 280 twins in a classic twin study design, including monozygotic (MZ) and dizygotic (DZ) pairs concordant and discordant for schizophrenia, and healthy control twins. We assessed episodic memory using subtests of the Wechsler Memory Scale -Revised (WMS-R).Results Genetic influences (i.e. heritability) contributed significantly to variance in immediate recall of both verbal memory and visual learning, and the delayed recall of verbal and visual memory. Liability to schizophrenia was associated with memory impairment, with evidence of significant phenotypic correlations between all episodic memory measures and schizophrenia. Genetic factors were the main source of the phenotypic correlations for immediate recall of visual learning material; both immediate and delayed recall of verbal memory; and delayed recall of visual memory that, for example, shared genetic variance with schizophrenia, which accounted for 88% of the phenotypic correlation (rph=0.41) between the two.Conclusions Verbal memory and visual learning and memory are moderately heritable, share a genetic overlap with schizophrenia and are valid endophenotypes for the condition. The inclusion of these endophenotypes in genetic association studies may improve the power to detect susceptibility genes for schizophrenia. © 2010 Cambridge University Press.en_HK
dc.languageengen_US
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=PSMen_HK
dc.relation.ispartofPsychological Medicineen_HK
dc.subjectEndophenotypeen_HK
dc.subjectmemoryen_HK
dc.subjectneurocognitionen_HK
dc.subjectschizophreniaen_HK
dc.subjecttwinsen_HK
dc.titleGenetic overlap between episodic memory deficits and schizophrenia: Results from the Maudsley Twin Studyen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1017/S0033291710000942en_HK
dc.identifier.pmid20459888-
dc.identifier.scopuseid_2-s2.0-79952315009en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952315009&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue3en_HK
dc.identifier.spage521en_HK
dc.identifier.epage532en_HK
dc.identifier.eissn1469-8978-
dc.identifier.isiWOS:000287622100008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridOwens, SF=36027261600en_HK
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_HK
dc.identifier.scopusauthoridRijsdijk, FV=6701830835en_HK
dc.identifier.scopusauthoridStahl, D=23669226600en_HK
dc.identifier.scopusauthoridVassos, E=35369293900en_HK
dc.identifier.scopusauthoridRodger, AK=36027106600en_HK
dc.identifier.scopusauthoridCollier, DA=26642980600en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK

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