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Article: Genetic overlap between schizophrenia and selective components of executive function

TitleGenetic overlap between schizophrenia and selective components of executive function
Authors
KeywordsEndophenotype
Executive function
Genetic
Neurocognition
Schizophrenia
Trail making test
Twin
Verbal fluency
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
Schizophrenia Research, 2011, v. 127 n. 1-3, p. 181-187 How to Cite?
AbstractImpairments in selective components of executive function are seen in unaffected family members of patients with schizophrenia and may represent the biological expression of increased genetic risk. However no study has quantified the extent to which liability to schizophrenia overlaps genetically with that of executive dysfunction. We studied a total of 418 monozygotic and dizygotic twins, including pairs concordant and discordant for schizophrenia. Participants completed the trail making test part A and verbal fluency tasks to assess initiation, TMT part B to test mental flexibility, and the WAIS-III to assess general intellectual function. Bivariate genetic modeling was used to investigate whether selective measures of executive processing are genetically linked to schizophrenia and to quantify the genetic (i.e. heritability) and environmental contributions to their variability. Genetic influences contributed substantially to test variance for initiation and mental flexibility. Genetic factors were the main source of the phenotypic correlations between schizophrenia and these processes. Verbal fluency tasks shared a large genetic correlation with IQ whilst TMT scales did not, suggesting that they measure discreet processes, and therefore indexing discreet endophenotypes. Both verbal fluency and mental flexibility meet some of the criteria for endophenotypes, but our data suggest that mental flexibility is a purer cognitive process sharing very little common variance with general intellectual functioning. The inclusion of this mental flexibility phenotype in linkage or association analysis should improve the power to detect susceptibility genes for schizophrenia. © 2010 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/141817
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOwens, SFen_HK
dc.contributor.authorRijsdijk, Fen_HK
dc.contributor.authorPicchioni, MMen_HK
dc.contributor.authorStahl, Den_HK
dc.contributor.authorNenadic, Ien_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.date.accessioned2011-09-27T03:02:33Z-
dc.date.available2011-09-27T03:02:33Z-
dc.date.issued2011en_HK
dc.identifier.citationSchizophrenia Research, 2011, v. 127 n. 1-3, p. 181-187en_HK
dc.identifier.issn0920-9964en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141817-
dc.description.abstractImpairments in selective components of executive function are seen in unaffected family members of patients with schizophrenia and may represent the biological expression of increased genetic risk. However no study has quantified the extent to which liability to schizophrenia overlaps genetically with that of executive dysfunction. We studied a total of 418 monozygotic and dizygotic twins, including pairs concordant and discordant for schizophrenia. Participants completed the trail making test part A and verbal fluency tasks to assess initiation, TMT part B to test mental flexibility, and the WAIS-III to assess general intellectual function. Bivariate genetic modeling was used to investigate whether selective measures of executive processing are genetically linked to schizophrenia and to quantify the genetic (i.e. heritability) and environmental contributions to their variability. Genetic influences contributed substantially to test variance for initiation and mental flexibility. Genetic factors were the main source of the phenotypic correlations between schizophrenia and these processes. Verbal fluency tasks shared a large genetic correlation with IQ whilst TMT scales did not, suggesting that they measure discreet processes, and therefore indexing discreet endophenotypes. Both verbal fluency and mental flexibility meet some of the criteria for endophenotypes, but our data suggest that mental flexibility is a purer cognitive process sharing very little common variance with general intellectual functioning. The inclusion of this mental flexibility phenotype in linkage or association analysis should improve the power to detect susceptibility genes for schizophrenia. © 2010 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schresen_HK
dc.relation.ispartofSchizophrenia Researchen_HK
dc.subjectEndophenotypeen_HK
dc.subjectExecutive functionen_HK
dc.subjectGeneticen_HK
dc.subjectNeurocognitionen_HK
dc.subjectSchizophreniaen_HK
dc.subjectTrail making testen_HK
dc.subjectTwinen_HK
dc.subjectVerbal fluencyen_HK
dc.titleGenetic overlap between schizophrenia and selective components of executive functionen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.schres.2010.10.010en_HK
dc.identifier.pmid21056927-
dc.identifier.scopuseid_2-s2.0-79952311373en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952311373&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume127en_HK
dc.identifier.issue1-3en_HK
dc.identifier.spage181en_HK
dc.identifier.epage187en_HK
dc.identifier.eissn1573-2509-
dc.identifier.isiWOS:000289395100029-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridOwens, SF=36027261600en_HK
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_HK
dc.identifier.scopusauthoridPicchioni, MM=6507443795en_HK
dc.identifier.scopusauthoridStahl, D=23669226600en_HK
dc.identifier.scopusauthoridNenadic, I=6603332362en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.citeulike8272023-

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