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Article: Putative diffusion tensor neuroimaging endophenotypes in schizophrenia: A review of the early evidence

TitlePutative diffusion tensor neuroimaging endophenotypes in schizophrenia: A review of the early evidence
Authors
Keywordsdiffusion tensor imaging
endophenotype
family
heritability
schizophrenia
twin
white matter
Issue Date2011
PublisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fnl
Citation
Future Neurology, 2011, v. 6 n. 3, p. 415-433 How to Cite?
AbstractAlthough schizophrenia has a high heritability, the genetic effects conferring diathesis to schizophrenia are thought to be complex and underlain by multifactorial polygenic inheritance. 'Endophenotypes', or 'intermediate phenotypes', are narrowed constructs of genetic risk that are assumed to be more proximal to the gene effects in the disease pathway than clinical phenotypes. A current aim in schizophrenia research is to identify promising putative endophenotypes for use in molecular genetics studies. Recently, much of the focus has been on neurocognitive, conventional T1-weighted structural MRI, functional MRI and electrophysiological endophenotypes. Diffusion tensor imaging has emerged as another important structural neuroimaging modality in the aim to identify abnormalities in brain connectivity and diffusivity in schizophrenia, and abnormalities detected via this method may be promising candidate endophenotypes. In this article, we present the first comprehensive review of the early evidence that qualifies diffusion tensor abnormalities as potentially appropriate endophenotypes of schizophrenia. © 2011 Future Medicine Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/141815
ISSN
2015 SCImago Journal Rankings: 0.510
References

 

DC FieldValueLanguage
dc.contributor.authorWatersMetenier, SLen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.date.accessioned2011-09-27T03:02:31Z-
dc.date.available2011-09-27T03:02:31Z-
dc.date.issued2011en_HK
dc.identifier.citationFuture Neurology, 2011, v. 6 n. 3, p. 415-433en_HK
dc.identifier.issn1479-6708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141815-
dc.description.abstractAlthough schizophrenia has a high heritability, the genetic effects conferring diathesis to schizophrenia are thought to be complex and underlain by multifactorial polygenic inheritance. 'Endophenotypes', or 'intermediate phenotypes', are narrowed constructs of genetic risk that are assumed to be more proximal to the gene effects in the disease pathway than clinical phenotypes. A current aim in schizophrenia research is to identify promising putative endophenotypes for use in molecular genetics studies. Recently, much of the focus has been on neurocognitive, conventional T1-weighted structural MRI, functional MRI and electrophysiological endophenotypes. Diffusion tensor imaging has emerged as another important structural neuroimaging modality in the aim to identify abnormalities in brain connectivity and diffusivity in schizophrenia, and abnormalities detected via this method may be promising candidate endophenotypes. In this article, we present the first comprehensive review of the early evidence that qualifies diffusion tensor abnormalities as potentially appropriate endophenotypes of schizophrenia. © 2011 Future Medicine Ltd.en_HK
dc.languageengen_US
dc.publisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fnlen_HK
dc.relation.ispartofFuture Neurologyen_HK
dc.subjectdiffusion tensor imagingen_HK
dc.subjectendophenotypeen_HK
dc.subjectfamilyen_HK
dc.subjectheritabilityen_HK
dc.subjectschizophreniaen_HK
dc.subjecttwinen_HK
dc.subjectwhite matteren_HK
dc.titlePutative diffusion tensor neuroimaging endophenotypes in schizophrenia: A review of the early evidenceen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2217/fnl.11.16en_HK
dc.identifier.scopuseid_2-s2.0-79955643515en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955643515&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue3en_HK
dc.identifier.spage415en_HK
dc.identifier.epage433en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWatersMetenier, SL=36550861500en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.citeulike9257026-

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