File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The early auditory gamma-band response is heritable and a putative endophenotype of schizophrenia

TitleThe early auditory gamma-band response is heritable and a putative endophenotype of schizophrenia
Authors
Keywordsendophenotype
gamma oscillation
heritability
schizophrenia
twin
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/
Citation
Schizophrenia Bulletin, 2011, v. 37 n. 4, p. 778-787 How to Cite?
AbstractBackground: Reduced power and phase locking of the early auditory gamma-band response (EAGBR) have been reported in schizophrenia, but findings are equivocal. Further, little is known about genetic (heritability) and environmental influences on the EAGBR or its potential as an endophenotype of schizophrenia. The present study used a twin design to examine whether EAGBR power and phase locking are heritable and reduced in schizophrenic patients and their unaffected co-twins and thus putative endophenotypes of schizophrenia. Methods: The study sample included a total of 194 individuals, consisting of 15 monozygotic [MZ] twin pairs concordant for schizophrenia, 9 MZ twin pairs discordant for schizophrenia, and 42 MZ and 31 dizygotic (DZ) control pairs. Evoked power and phase-locking factor of the EAGBR were computed on Morlet wavelet-transformed electroencephalogram responses to standard tones during an auditory oddball target detection task. Structural equation modeling was applied to estimate heritability and genetic and environmental correlations with schizophrenia for the EAGBR measures. Results: Both evoked power and phase-locking phenotypes were heritable traits (power: h 2 = 0.65; phase locking: h 2 = 0.63). Impaired EAGBR measures were significantly associated with schizophrenia. Patients with schizophrenia and their unaffected identical co-twins exhibited significantly reduced EAGBR power compared with control subjects. In each phenotype, shared genetic factors were likely the source of the observed associations with schizophrenia. Conclusions: Our results support EAGBR measures as putative endophenotypes of schizophrenia, likely reflecting an ubiquitous local cortical circuit deficit. © The Author 2011. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141813
ISSN
2015 Impact Factor: 7.757
2015 SCImago Journal Rankings: 4.051
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Harvard Medical School
National Alliance for Research on Schizophrenia and Depression (Sidney)
Adam Corneel Young Investigator Award
National Institutes of Mental HealthT32 MH01 6259-29A 1
MH RO1-58704
Wellcome Trust064971
Funding Information:

Harvard Medical School (Kaplen Fellowship to M.-H.H.); National Alliance for Research on Schizophrenia and Depression (Sidney R. Baer, Jr. Foundation Young Investigator Award to M.-H.H.); Adam Corneel Young Investigator Award (to M.-H.H.); National Institutes of Mental Health (T32 MH01 6259-29A 1 Fellowship to M.-H.H., MH RO1-58704 to D.F.S.); Wellcome Trust (Research Training Fellowship 064971 to M.P.).

References

 

DC FieldValueLanguage
dc.contributor.authorHall, MHen_HK
dc.contributor.authorTaylor, Gen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorSchulze, Ken_HK
dc.contributor.authorRijsdijk, Fen_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorEttinger, Uen_HK
dc.contributor.authorBramon, Een_HK
dc.contributor.authorMurray, RMen_HK
dc.contributor.authorSalisbury, DFen_HK
dc.date.accessioned2011-09-27T03:02:30Z-
dc.date.available2011-09-27T03:02:30Z-
dc.date.issued2011en_HK
dc.identifier.citationSchizophrenia Bulletin, 2011, v. 37 n. 4, p. 778-787en_HK
dc.identifier.issn0586-7614en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141813-
dc.description.abstractBackground: Reduced power and phase locking of the early auditory gamma-band response (EAGBR) have been reported in schizophrenia, but findings are equivocal. Further, little is known about genetic (heritability) and environmental influences on the EAGBR or its potential as an endophenotype of schizophrenia. The present study used a twin design to examine whether EAGBR power and phase locking are heritable and reduced in schizophrenic patients and their unaffected co-twins and thus putative endophenotypes of schizophrenia. Methods: The study sample included a total of 194 individuals, consisting of 15 monozygotic [MZ] twin pairs concordant for schizophrenia, 9 MZ twin pairs discordant for schizophrenia, and 42 MZ and 31 dizygotic (DZ) control pairs. Evoked power and phase-locking factor of the EAGBR were computed on Morlet wavelet-transformed electroencephalogram responses to standard tones during an auditory oddball target detection task. Structural equation modeling was applied to estimate heritability and genetic and environmental correlations with schizophrenia for the EAGBR measures. Results: Both evoked power and phase-locking phenotypes were heritable traits (power: h 2 = 0.65; phase locking: h 2 = 0.63). Impaired EAGBR measures were significantly associated with schizophrenia. Patients with schizophrenia and their unaffected identical co-twins exhibited significantly reduced EAGBR power compared with control subjects. In each phenotype, shared genetic factors were likely the source of the observed associations with schizophrenia. Conclusions: Our results support EAGBR measures as putative endophenotypes of schizophrenia, likely reflecting an ubiquitous local cortical circuit deficit. © The Author 2011. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://schizophreniabulletin.oxfordjournals.org/en_HK
dc.relation.ispartofSchizophrenia Bulletinen_HK
dc.subjectendophenotypeen_HK
dc.subjectgamma oscillationen_HK
dc.subjectheritabilityen_HK
dc.subjectschizophreniaen_HK
dc.subjecttwinen_HK
dc.titleThe early auditory gamma-band response is heritable and a putative endophenotype of schizophreniaen_HK
dc.typeArticleen_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailToulopoulou, T: timothea@hku.hken_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1093/schbul/sbp134en_HK
dc.identifier.pmid19946013-
dc.identifier.pmcidPMC3122286-
dc.identifier.scopuseid_2-s2.0-79959706727en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79959706727&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue4en_HK
dc.identifier.spage778en_HK
dc.identifier.epage787en_HK
dc.identifier.eissn1745-1701-
dc.identifier.isiWOS:000292527400017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHall, MH=14013171900en_HK
dc.identifier.scopusauthoridTaylor, G=36125472400en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridSchulze, K=7103137549en_HK
dc.identifier.scopusauthoridRijsdijk, F=6701830835en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridEttinger, U=6602766172en_HK
dc.identifier.scopusauthoridBramon, E=8089378900en_HK
dc.identifier.scopusauthoridMurray, RM=35406239400en_HK
dc.identifier.scopusauthoridSalisbury, DF=7005692119en_HK
dc.identifier.citeulike8886889-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats