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Article: Altered integrity of perisylvian language pathways in schizophrenia: Relationship to auditory hallucinations

TitleAltered integrity of perisylvian language pathways in schizophrenia: Relationship to auditory hallucinations
Authors
KeywordsArcuate fasciculus
auditory verbal hallucinations
diffusion tensor imaging
language
schizophrenia
tractography
white matter
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiat
Citation
Biological Psychiatry, 2011, v. 70 n. 12, p. 1143-1150 How to Cite?
AbstractBackground: Functional neuroimaging supports the hypothesis that auditory verbal hallucinations (AVH) in schizophrenia result from altered functional connectivity between perisylvian language regions, although the extent to which AVH are also associated with an altered tract anatomy is less clear. Methods: Twenty-eight patients with schizophrenia subdivided into 17 subjects with a history of AVH and 11 without a history of hallucinations and 59 age- and IQ-matched healthy controls were recruited. The number of streamlines, fractional anisotropy (FA), and mean diffusivity were measured along the length of the arcuate fasciculus and its medial and lateral components. Results: Patients with schizophrenia had bilateral reduction of FA relative to controls in the arcuate fasciculi (p <.001). Virtual dissection of the subcomponents of the arcuate fasciculi revealed that these reductions were specific to connections between posterior temporal and anterior regions in the inferior frontal and parietal lobe. Also, compared with controls, the reduction in FA of these tracts was highest, and bilateral, in patients with AVH, but in patients without AVH, this reduction was reported only on the left. Conclusions: These findings point toward a supraregional network model of AVH in schizophrenia. They support the hypothesis that there may be selective vulnerability of specific anatomical connections to posterior temporal regions in schizophrenia and that extensive bilateral damage is associated with a greater vulnerability to AVH. If confirmed by further studies, these findings may advance our understanding of the anatomical factors that are protective against AVH and predictive of a treatment response. © 2011 Society of Biological Psychiatry.
Persistent Identifierhttp://hdl.handle.net/10722/141812
ISSN
2015 Impact Factor: 11.212
2015 SCImago Journal Rankings: 5.823
ISI Accession Number ID
Funding AgencyGrant Number
Guy's and St. Thomas' Charity
Wellcome Trust
Medical Research Council, United Kingdom Autism Multi-Centre Imaging Study Network
National Division of the South London and Maudsley National Health Service Foundation Trust
Lilly
AstraZeneca
Bristol-Myers Squibb
Roche
Lundbeck
Janssen Cilag
Novartis
Sanofi Synthelabo
Pfizer
Eli-Lilly
Funding Information:

MC and SJF were supported by Guy's and St. Thomas' Charity. MC, RK, MP, and SS were sponsored by the Wellcome Trust. DGM and MC were partially supported by the Medical Research Council, United Kingdom Autism Multi-Centre Imaging Study Network, and the National Division of the South London and Maudsley National Health Service Foundation Trust. PM has received honoraria for lectures and consultancy fees from Lilly, AstraZeneca, Bristol-Myers Squibb, Roche, Lundbeck, and Janssen Cilag. SS has received honoraria or support to attend conferences from Janssen Cilag, Lilly, Novartis, and Sanofi Synthelabo and unrestricted project grant support from Novartis and AstraZeneca. MP has received travel awards from Pfizer, Janssen-Cilag, and Eli-Lilly. The other authors report no biomedical financial interests or potential conflicts of interest.

References

 

DC FieldValueLanguage
dc.contributor.authorCatani, Men_HK
dc.contributor.authorCraig, MCen_HK
dc.contributor.authorForkel, SJen_HK
dc.contributor.authorKanaan, Ren_HK
dc.contributor.authorPicchioni, Men_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.contributor.authorShergill, Sen_HK
dc.contributor.authorWilliams, Sen_HK
dc.contributor.authorMurphy, DGen_HK
dc.contributor.authorMcGuire, Pen_HK
dc.date.accessioned2011-09-27T03:02:27Z-
dc.date.available2011-09-27T03:02:27Z-
dc.date.issued2011en_HK
dc.identifier.citationBiological Psychiatry, 2011, v. 70 n. 12, p. 1143-1150en_HK
dc.identifier.issn0006-3223en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141812-
dc.description.abstractBackground: Functional neuroimaging supports the hypothesis that auditory verbal hallucinations (AVH) in schizophrenia result from altered functional connectivity between perisylvian language regions, although the extent to which AVH are also associated with an altered tract anatomy is less clear. Methods: Twenty-eight patients with schizophrenia subdivided into 17 subjects with a history of AVH and 11 without a history of hallucinations and 59 age- and IQ-matched healthy controls were recruited. The number of streamlines, fractional anisotropy (FA), and mean diffusivity were measured along the length of the arcuate fasciculus and its medial and lateral components. Results: Patients with schizophrenia had bilateral reduction of FA relative to controls in the arcuate fasciculi (p <.001). Virtual dissection of the subcomponents of the arcuate fasciculi revealed that these reductions were specific to connections between posterior temporal and anterior regions in the inferior frontal and parietal lobe. Also, compared with controls, the reduction in FA of these tracts was highest, and bilateral, in patients with AVH, but in patients without AVH, this reduction was reported only on the left. Conclusions: These findings point toward a supraregional network model of AVH in schizophrenia. They support the hypothesis that there may be selective vulnerability of specific anatomical connections to posterior temporal regions in schizophrenia and that extensive bilateral damage is associated with a greater vulnerability to AVH. If confirmed by further studies, these findings may advance our understanding of the anatomical factors that are protective against AVH and predictive of a treatment response. © 2011 Society of Biological Psychiatry.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biopsychiaten_HK
dc.relation.ispartofBiological Psychiatryen_HK
dc.subjectArcuate fasciculusen_HK
dc.subjectauditory verbal hallucinationsen_HK
dc.subjectdiffusion tensor imagingen_HK
dc.subjectlanguageen_HK
dc.subjectschizophreniaen_HK
dc.subjecttractographyen_HK
dc.subjectwhite matteren_HK
dc.titleAltered integrity of perisylvian language pathways in schizophrenia: Relationship to auditory hallucinationsen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.biopsych.2011.06.013en_HK
dc.identifier.pmid21798516-
dc.identifier.scopuseid_2-s2.0-81855221840en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81855221840&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1143en_HK
dc.identifier.epage1150en_HK
dc.identifier.isiWOS:000297980000009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCatani, M=35309856300en_HK
dc.identifier.scopusauthoridCraig, MC=7103269626en_HK
dc.identifier.scopusauthoridForkel, SJ=43661092300en_HK
dc.identifier.scopusauthoridKanaan, R=12545783400en_HK
dc.identifier.scopusauthoridPicchioni, M=6507443795en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK
dc.identifier.scopusauthoridShergill, S=35433190700en_HK
dc.identifier.scopusauthoridWilliams, S=35419560700en_HK
dc.identifier.scopusauthoridMurphy, DG=7404062227en_HK
dc.identifier.scopusauthoridMcGuire, P=7101880438en_HK
dc.identifier.citeulike9628736-

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