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Article: Putative structural neuroimaging endophenotypes in schizophrenia: A comprehensive review of the current evidence

TitlePutative structural neuroimaging endophenotypes in schizophrenia: A comprehensive review of the current evidence
Authors
Keywordsendophenotype
families
heritability
ROI
schizophrenia
structural MRI
twins
VBM
Issue Date2011
PublisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fnl
Citation
Future Neurology, 2011, v. 6 n. 5, p. 679-715 How to Cite?
AbstractThe genetic contribution to schizophrenia etiopathogenesis is underscored by the fact that the best predictor of developing schizophrenia is having an affected first-degree relative, which increases lifetime risk by tenfold, as well as the observation that when both parents are affected, the risk of schizophrenia increases to approximately 50%, compared with 1% in the general population. The search to elucidate the complex genetic architecture of schizophrenia has employed various approaches, including twin and family studies to examine co-aggregation of brain abnormalities, studies on genetic linkage and studies using genome-wide association to identify genetic variations associated with schizophrenia. 'Endophenotypes, or 'intermediate phenotypes, are potentially narrower constructs of genetic risk. Hypothetically, they are intermediate in the pathway between genetic variation and clinical phenotypes and can supposedly be implemented to assist in the identification of genetic diathesis for schizophrenia and, possibly, in redefining clinical phenomenology. © 2011 Future Medicine Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/141811
ISSN
2015 SCImago Journal Rankings: 0.510
References

 

DC FieldValueLanguage
dc.contributor.authorWatersMetenier, Sen_HK
dc.contributor.authorToulopoulou, Ten_HK
dc.date.accessioned2011-09-27T03:02:25Z-
dc.date.available2011-09-27T03:02:25Z-
dc.date.issued2011en_HK
dc.identifier.citationFuture Neurology, 2011, v. 6 n. 5, p. 679-715en_HK
dc.identifier.issn1479-6708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141811-
dc.description.abstractThe genetic contribution to schizophrenia etiopathogenesis is underscored by the fact that the best predictor of developing schizophrenia is having an affected first-degree relative, which increases lifetime risk by tenfold, as well as the observation that when both parents are affected, the risk of schizophrenia increases to approximately 50%, compared with 1% in the general population. The search to elucidate the complex genetic architecture of schizophrenia has employed various approaches, including twin and family studies to examine co-aggregation of brain abnormalities, studies on genetic linkage and studies using genome-wide association to identify genetic variations associated with schizophrenia. 'Endophenotypes, or 'intermediate phenotypes, are potentially narrower constructs of genetic risk. Hypothetically, they are intermediate in the pathway between genetic variation and clinical phenotypes and can supposedly be implemented to assist in the identification of genetic diathesis for schizophrenia and, possibly, in redefining clinical phenomenology. © 2011 Future Medicine Ltd.en_HK
dc.languageengen_US
dc.publisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/fnlen_HK
dc.relation.ispartofFuture Neurologyen_HK
dc.subjectendophenotypeen_HK
dc.subjectfamiliesen_HK
dc.subjectheritabilityen_HK
dc.subjectROIen_HK
dc.subjectschizophreniaen_HK
dc.subjectstructural MRIen_HK
dc.subjecttwinsen_HK
dc.subjectVBMen_HK
dc.titlePutative structural neuroimaging endophenotypes in schizophrenia: A comprehensive review of the current evidenceen_HK
dc.typeArticleen_HK
dc.identifier.emailToulopoulou, T:timothea@hku.hken_HK
dc.identifier.authorityToulopoulou, T=rp01542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2217/fnl.11.35en_HK
dc.identifier.scopuseid_2-s2.0-80052311771en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052311771&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue5en_HK
dc.identifier.spage679en_HK
dc.identifier.epage715en_HK
dc.identifier.eissn1748-6971-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWatersMetenier, S=36550861500en_HK
dc.identifier.scopusauthoridToulopoulou, T=8855468700en_HK

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