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Article: Effect of spacers on the electrostatic charge properties of metered dose inhaler aerosols

TitleEffect of spacers on the electrostatic charge properties of metered dose inhaler aerosols
Authors
KeywordsElectrostatic charge
ELPI
MDI
Pharmaceutical aerosol
Spacer
Issue Date2006
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jaerosci
Citation
Journal Of Aerosol Science, 2006, v. 37 n. 12, p. 1671-1682 How to Cite?
AbstractThe electrostatic charge properties of commercial metered dose inhaler (MDI) aerosols, including Ventolin®, Flixotide®, Tilade® and QVAR®, sampled through new and detergent-coated AeroChamber® Plus spacers were studied using a modified 13-stage electrical low pressure impactor (ELPI) with aerodynamic cutoff diameters ranging from 0.028 to 10.07 μ m. Aerosol particles deposited on the impactor stages according to their aerodynamic diameters and their charges were simultaneously measured by the electrometers. The deposited drug mass was assayed chemically using HPLC. The surface potential on the inner spacer wall was measured with an electrostatic probe before and after aerosol actuation. High surface potentials were found on the new spacers whereas the detergent-coated spacers had minimal charges due to the conductive coating. MDI aerosol charges were decreased when spacers were used but the charge profiles of the aerosols were not altered qualitatively. New spacers had the lowest throat deposition, fine particle dose, and net aerosol and fine particle charges as a result of high spacer retention. These trends were partially reversed by the detergent-coated spacers. In general, the charge per mass of drug (charge-to-mass ratio) for particles from detergent-coated spacers was higher than those from new spacers. This was thought to be due to the reduction of electrostatic deposition inside the spacer thus leading to particles carrying higher charges being sampled. The calculated number of elementary charges per drug particle ranged from zero to several hundred, which is sufficiently high to potentially affect lung deposition. The ELPI provided high resolution charge profiles on MDI aerosols delivered through spacers. © 2006 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141736
ISSN
2015 Impact Factor: 2.278
2015 SCImago Journal Rankings: 1.702
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwok, PCLen_HK
dc.contributor.authorCollins, Ren_HK
dc.contributor.authorChan, HKen_HK
dc.date.accessioned2011-09-27T02:59:46Z-
dc.date.available2011-09-27T02:59:46Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal Of Aerosol Science, 2006, v. 37 n. 12, p. 1671-1682en_HK
dc.identifier.issn0021-8502en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141736-
dc.description.abstractThe electrostatic charge properties of commercial metered dose inhaler (MDI) aerosols, including Ventolin®, Flixotide®, Tilade® and QVAR®, sampled through new and detergent-coated AeroChamber® Plus spacers were studied using a modified 13-stage electrical low pressure impactor (ELPI) with aerodynamic cutoff diameters ranging from 0.028 to 10.07 μ m. Aerosol particles deposited on the impactor stages according to their aerodynamic diameters and their charges were simultaneously measured by the electrometers. The deposited drug mass was assayed chemically using HPLC. The surface potential on the inner spacer wall was measured with an electrostatic probe before and after aerosol actuation. High surface potentials were found on the new spacers whereas the detergent-coated spacers had minimal charges due to the conductive coating. MDI aerosol charges were decreased when spacers were used but the charge profiles of the aerosols were not altered qualitatively. New spacers had the lowest throat deposition, fine particle dose, and net aerosol and fine particle charges as a result of high spacer retention. These trends were partially reversed by the detergent-coated spacers. In general, the charge per mass of drug (charge-to-mass ratio) for particles from detergent-coated spacers was higher than those from new spacers. This was thought to be due to the reduction of electrostatic deposition inside the spacer thus leading to particles carrying higher charges being sampled. The calculated number of elementary charges per drug particle ranged from zero to several hundred, which is sufficiently high to potentially affect lung deposition. The ELPI provided high resolution charge profiles on MDI aerosols delivered through spacers. © 2006 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/jaeroscien_HK
dc.relation.ispartofJournal of Aerosol Scienceen_HK
dc.subjectElectrostatic chargeen_HK
dc.subjectELPIen_HK
dc.subjectMDIen_HK
dc.subjectPharmaceutical aerosolen_HK
dc.subjectSpaceren_HK
dc.titleEffect of spacers on the electrostatic charge properties of metered dose inhaler aerosolsen_HK
dc.typeArticleen_HK
dc.identifier.emailKwok, PCL: pclkwok@hku.hken_HK
dc.identifier.authorityKwok, PCL=rp01540en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jaerosci.2006.08.008en_HK
dc.identifier.scopuseid_2-s2.0-33750682273en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750682273&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1671en_HK
dc.identifier.epage1682en_HK
dc.identifier.isiWOS:000242783500003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKwok, PCL=12646007800en_HK
dc.identifier.scopusauthoridCollins, R=7403350627en_HK
dc.identifier.scopusauthoridChan, HK=7403402677en_HK

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