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Article: Influence of humidity on the electrostatic charge and aerosol performance of dry powder inhaler carrier based systems

TitleInfluence of humidity on the electrostatic charge and aerosol performance of dry powder inhaler carrier based systems
Authors
KeywordsAerosol
DPI
Dry powder inhaler
Electrostatics
ELPI
Humidity
Inhalation
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741
Citation
Pharmaceutical Research, 2007, v. 24 n. 5, p. 963-970 How to Cite?
AbstractTo investigate the influence of storage relative humidity (RH) on the aerosolisation efficiency and tribo-electrification of carrier based dry powder inhaler (DPI) formulations using the next generation impactor (NGI) in vitro methodology and the electrostatic low pressure impactor (ELPI). Micronised salbutamol (d 0.5 1.48 ± 0.03 μm) was blended with 63-90 μm sieve fractioned α-lactose monohydrate carrier and stored at a range of humidities (0-84% RH). The aerosolisation efficiency after storage for 24 h periods was investigated using the NGI. The same experiment was conducted using the ELPI, with corona charger switched off, to measure the net charge vs. mass deposition profile. Significant variations in the aerosolisation efficiency of the formulation were observed with respect to storage RH. In general, the fine particle fraction aerosol performance measured by NGI and ELPI (fraction with mass median aerodynamic diameter <4.46 and 4.04 μm, respectively) followed a positive parabola with aerosol performance increasing over the range 0-60% RH before decreasing >60% RH. Analysis of the ELPI charge data suggested that the micronised salbutamol sulphate had an electronegative charge when aerosolised from lactose based carriers, which was most electronegative at low RH. Increased storage RH resulted in a reduction in net charge to mass ratio with the greatest reduction at RH >60%. The aerosol performance of this binary system is dependent on both electrostatic and capillary forces. The use of the ELPI allows a degree of insight into how these forces affect formulation performances after storage at different RH. © 2007 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/141735
ISSN
2015 Impact Factor: 3.26
2015 SCImago Journal Rankings: 1.189
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYoung, PMen_HK
dc.contributor.authorSung, Aen_HK
dc.contributor.authorTraini, Den_HK
dc.contributor.authorKwok, Pen_HK
dc.contributor.authorChiou, Hen_HK
dc.contributor.authorChan, HKen_HK
dc.date.accessioned2011-09-27T02:59:45Z-
dc.date.available2011-09-27T02:59:45Z-
dc.date.issued2007en_HK
dc.identifier.citationPharmaceutical Research, 2007, v. 24 n. 5, p. 963-970en_HK
dc.identifier.issn0724-8741en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141735-
dc.description.abstractTo investigate the influence of storage relative humidity (RH) on the aerosolisation efficiency and tribo-electrification of carrier based dry powder inhaler (DPI) formulations using the next generation impactor (NGI) in vitro methodology and the electrostatic low pressure impactor (ELPI). Micronised salbutamol (d 0.5 1.48 ± 0.03 μm) was blended with 63-90 μm sieve fractioned α-lactose monohydrate carrier and stored at a range of humidities (0-84% RH). The aerosolisation efficiency after storage for 24 h periods was investigated using the NGI. The same experiment was conducted using the ELPI, with corona charger switched off, to measure the net charge vs. mass deposition profile. Significant variations in the aerosolisation efficiency of the formulation were observed with respect to storage RH. In general, the fine particle fraction aerosol performance measured by NGI and ELPI (fraction with mass median aerodynamic diameter <4.46 and 4.04 μm, respectively) followed a positive parabola with aerosol performance increasing over the range 0-60% RH before decreasing >60% RH. Analysis of the ELPI charge data suggested that the micronised salbutamol sulphate had an electronegative charge when aerosolised from lactose based carriers, which was most electronegative at low RH. Increased storage RH resulted in a reduction in net charge to mass ratio with the greatest reduction at RH >60%. The aerosol performance of this binary system is dependent on both electrostatic and capillary forces. The use of the ELPI allows a degree of insight into how these forces affect formulation performances after storage at different RH. © 2007 Springer Science+Business Media, LLC.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741en_HK
dc.relation.ispartofPharmaceutical Researchen_HK
dc.subjectAerosolen_HK
dc.subjectDPIen_HK
dc.subjectDry powder inhaleren_HK
dc.subjectElectrostaticsen_HK
dc.subjectELPIen_HK
dc.subjectHumidityen_HK
dc.subjectInhalationen_HK
dc.titleInfluence of humidity on the electrostatic charge and aerosol performance of dry powder inhaler carrier based systemsen_HK
dc.typeArticleen_HK
dc.identifier.emailKwok, P: pclkwok@hku.hken_HK
dc.identifier.authorityKwok, P=rp01540en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11095-006-9218-8en_HK
dc.identifier.pmid17377746-
dc.identifier.scopuseid_2-s2.0-34247569453en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247569453&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue5en_HK
dc.identifier.spage963en_HK
dc.identifier.epage970en_HK
dc.identifier.eissn1573-904X-
dc.identifier.isiWOS:000246112300013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYoung, PM=7402037987en_HK
dc.identifier.scopusauthoridSung, A=16246178300en_HK
dc.identifier.scopusauthoridTraini, D=10142464500en_HK
dc.identifier.scopusauthoridKwok, P=12646007800en_HK
dc.identifier.scopusauthoridChiou, H=15053032800en_HK
dc.identifier.scopusauthoridChan, HK=7403402677en_HK
dc.identifier.citeulike1411714-

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