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Article: Effect of relative humidity on the electrostatic charge properties of dry powder inhaler aerosols

TitleEffect of relative humidity on the electrostatic charge properties of dry powder inhaler aerosols
Authors
KeywordsAerosol
Dry powder inhaler
Electrostatic charge
ELPI
Relative humidity
Issue Date2008
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741
Citation
Pharmaceutical Research, 2008, v. 25 n. 2, p. 277-288 How to Cite?
AbstractPurpose. At present, there is no published data examining the effect of relative humidity on the electrostatic charges of dry powder inhaler aerosols. The charging behaviour of two commercial products, Pulmicort® and Bricanyl® Turbuhalers®, were investigated using an electrical low pressure impactor (ELPI). Methods. ELPI was successfully modified to disperse the aerosols at 60 l/min. Four doses from each new inhaler were sampled at 15, 40, 65, and 90% RH. Particles deposited on the impactor stages according to their aerodynamic diameters and their charges were measured simultaneously by the electrometers. The drug in each size fraction was quantified using HPLC. Results. Both products generated bipolar charges. The charging behaviour of the two types of inhaler showed different humidity dependence although the mass output was not significantly affected. The absolute specific charge of budesonide fine particles from Pulmicort® was the lowest at 40% RH but increased at lower and higher RHs. In contrast, the terbutaline sulfate fine particles from Bricanyl® followed the expected trend of charge reduction with increasing RH. Conclusions. The distinct trends of charging of aerosols from Pulmicort® and Bricanyl® Turbuhalers® was explained by differences in hygroscopicity and other physicochemical factors between the two drugs. © 2007 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/141734
ISSN
2015 Impact Factor: 3.26
2015 SCImago Journal Rankings: 1.189
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwok, PCLen_HK
dc.contributor.authorChan, HKen_HK
dc.date.accessioned2011-09-27T02:59:45Z-
dc.date.available2011-09-27T02:59:45Z-
dc.date.issued2008en_HK
dc.identifier.citationPharmaceutical Research, 2008, v. 25 n. 2, p. 277-288en_HK
dc.identifier.issn0724-8741en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141734-
dc.description.abstractPurpose. At present, there is no published data examining the effect of relative humidity on the electrostatic charges of dry powder inhaler aerosols. The charging behaviour of two commercial products, Pulmicort® and Bricanyl® Turbuhalers®, were investigated using an electrical low pressure impactor (ELPI). Methods. ELPI was successfully modified to disperse the aerosols at 60 l/min. Four doses from each new inhaler were sampled at 15, 40, 65, and 90% RH. Particles deposited on the impactor stages according to their aerodynamic diameters and their charges were measured simultaneously by the electrometers. The drug in each size fraction was quantified using HPLC. Results. Both products generated bipolar charges. The charging behaviour of the two types of inhaler showed different humidity dependence although the mass output was not significantly affected. The absolute specific charge of budesonide fine particles from Pulmicort® was the lowest at 40% RH but increased at lower and higher RHs. In contrast, the terbutaline sulfate fine particles from Bricanyl® followed the expected trend of charge reduction with increasing RH. Conclusions. The distinct trends of charging of aerosols from Pulmicort® and Bricanyl® Turbuhalers® was explained by differences in hygroscopicity and other physicochemical factors between the two drugs. © 2007 Springer Science+Business Media, LLC.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741en_HK
dc.relation.ispartofPharmaceutical Researchen_HK
dc.subjectAerosolen_HK
dc.subjectDry powder inhaleren_HK
dc.subjectElectrostatic chargeen_HK
dc.subjectELPIen_HK
dc.subjectRelative humidityen_HK
dc.titleEffect of relative humidity on the electrostatic charge properties of dry powder inhaler aerosolsen_HK
dc.typeArticleen_HK
dc.identifier.emailKwok, PCL: pclkwok@hku.hken_HK
dc.identifier.authorityKwok, PCL=rp01540en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11095-007-9377-2en_HK
dc.identifier.pmid17619997-
dc.identifier.scopuseid_2-s2.0-39149106150en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39149106150&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue2en_HK
dc.identifier.spage277en_HK
dc.identifier.epage288en_HK
dc.identifier.eissn1573-904X-
dc.identifier.isiWOS:000253216100004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwok, PCL=12646007800en_HK
dc.identifier.scopusauthoridChan, HK=7403402677en_HK

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