File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Lactose composite carriers for respiratory delivery

TitleLactose composite carriers for respiratory delivery
Authors
KeywordsColloid probe microscopy
DPI composite
Dry powder inhalation
Inhalation
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741
Citation
Pharmaceutical Research, 2009, v. 26 n. 4, p. 802-810 How to Cite?
AbstractPurpose: Lactose dry powder inhaler (DPI) carriers, constructed of smaller sub units (composite carriers), were evaluated to assess their potential for minimising drug-carrier adhesion, variability in drug-carrier forces and influence on drug aerosol performance from carrier-drug blends. Methods: Lactose carrier particles were prepared by fusing sub units of lactose (either 2, 6 or 10 μm) in saturated lactose slurry. The resultant composite particles, as well as supplied lactose, were sieve fractioned to obtain a 63-90 μm carriers. The carriers were evaluated in terms of size (laser diffraction) morphology (electron microscopy and atomic force microscopy), crystallinity and drug adhesion (colloid probe microscopy). In addition, blends containing drug and carrier were prepared and evaluated in terms of drug aerosol performance. Results: The surface morphology and physico-chemical properties of the composite carriers were significantly different. Depending on the initial primary lactose size, the composite particles could be prepared with different surface roughness. Variation in composite roughness could be related to the change in drug adhesion (via modification in contact geometry) and thus drug aerosol performance from drug-lactose blends. Conclusion: Composite based carriers are a potential route to control drug-carrier adhesion forces and variability thus allowing more precise control of formulation performance. © 2008 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/141733
ISSN
2015 Impact Factor: 3.26
2015 SCImago Journal Rankings: 1.189
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYoung, PMen_HK
dc.contributor.authorKwok, Pen_HK
dc.contributor.authorAdi, Hen_HK
dc.contributor.authorChan, HKen_HK
dc.contributor.authorTraini, Den_HK
dc.date.accessioned2011-09-27T02:59:44Z-
dc.date.available2011-09-27T02:59:44Z-
dc.date.issued2009en_HK
dc.identifier.citationPharmaceutical Research, 2009, v. 26 n. 4, p. 802-810en_HK
dc.identifier.issn0724-8741en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141733-
dc.description.abstractPurpose: Lactose dry powder inhaler (DPI) carriers, constructed of smaller sub units (composite carriers), were evaluated to assess their potential for minimising drug-carrier adhesion, variability in drug-carrier forces and influence on drug aerosol performance from carrier-drug blends. Methods: Lactose carrier particles were prepared by fusing sub units of lactose (either 2, 6 or 10 μm) in saturated lactose slurry. The resultant composite particles, as well as supplied lactose, were sieve fractioned to obtain a 63-90 μm carriers. The carriers were evaluated in terms of size (laser diffraction) morphology (electron microscopy and atomic force microscopy), crystallinity and drug adhesion (colloid probe microscopy). In addition, blends containing drug and carrier were prepared and evaluated in terms of drug aerosol performance. Results: The surface morphology and physico-chemical properties of the composite carriers were significantly different. Depending on the initial primary lactose size, the composite particles could be prepared with different surface roughness. Variation in composite roughness could be related to the change in drug adhesion (via modification in contact geometry) and thus drug aerosol performance from drug-lactose blends. Conclusion: Composite based carriers are a potential route to control drug-carrier adhesion forces and variability thus allowing more precise control of formulation performance. © 2008 Springer Science+Business Media, LLC.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0724-8741en_HK
dc.relation.ispartofPharmaceutical Researchen_HK
dc.subjectColloid probe microscopyen_HK
dc.subjectDPI compositeen_HK
dc.subjectDry powder inhalationen_HK
dc.subjectInhalationen_HK
dc.titleLactose composite carriers for respiratory deliveryen_HK
dc.typeArticleen_HK
dc.identifier.emailKwok, P: pclkwok@hku.hken_HK
dc.identifier.authorityKwok, P=rp01540en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s11095-008-9779-9en_HK
dc.identifier.pmid19015956-
dc.identifier.scopuseid_2-s2.0-61449219797en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61449219797&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue4en_HK
dc.identifier.spage802en_HK
dc.identifier.epage810en_HK
dc.identifier.eissn1573-904X-
dc.identifier.isiWOS:000263799000006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYoung, PM=7402037987en_HK
dc.identifier.scopusauthoridKwok, P=12646007800en_HK
dc.identifier.scopusauthoridAdi, H=24466627000en_HK
dc.identifier.scopusauthoridChan, HK=7403402677en_HK
dc.identifier.scopusauthoridTraini, D=10142464500en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats