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Article: Does electrostatic charge affect powder aerosolisation?

TitleDoes electrostatic charge affect powder aerosolisation?
Authors
KeywordsAerosol
Agglomerate
Dry powder inhalation
Electrostatic charge
Mannitol
Surface energy
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.acs.org
Citation
Journal Of Pharmaceutical Sciences, 2010, v. 99 n. 5, p. 2455-2461 How to Cite?
AbstractTo study if electrostatic charge initially present in mannitol powder plays a role in the generation of aerosols, mannitol was unipolarly charged to varying magnitudes by tumbling the powder inside containers of different materials. The resulting charge in the powder was consistent with predictions from the triboelectric charging theories, based on the work function values from literature and electron transfer tendencies from measurement of contact angle. The latter generated a parameter, γ-/γ+, which is a measure of the electron-donating capacity relative to the electron-accepting tendency of material. Lowering the work function value or increasing the γ-/γ+ ratio of the container material resulted in mannitol being more negatively charged, and vice versa. After charging, the powder was dispersed from an Aerolizer®, at 30 and 60 L/min, to study the aerosol performance. Irrespective of the charge level, the powder showed similar fine particle fraction, emitted dose and device retention at a given flow rate, indicating that charge induced by different containers during tumbling does not play a significant role in mannitol powder aerosolisation. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association.
Persistent Identifierhttp://hdl.handle.net/10722/141729
ISSN
2015 Impact Factor: 2.641
2015 SCImago Journal Rankings: 0.984
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAdi, Hen_HK
dc.contributor.authorKwok, PCLen_HK
dc.contributor.authorCrapper, Jen_HK
dc.contributor.authorYoung, PMen_HK
dc.contributor.authorTraini, Den_HK
dc.contributor.authorChan, HKen_HK
dc.date.accessioned2011-09-27T02:59:42Z-
dc.date.available2011-09-27T02:59:42Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Pharmaceutical Sciences, 2010, v. 99 n. 5, p. 2455-2461en_HK
dc.identifier.issn0022-3549en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141729-
dc.description.abstractTo study if electrostatic charge initially present in mannitol powder plays a role in the generation of aerosols, mannitol was unipolarly charged to varying magnitudes by tumbling the powder inside containers of different materials. The resulting charge in the powder was consistent with predictions from the triboelectric charging theories, based on the work function values from literature and electron transfer tendencies from measurement of contact angle. The latter generated a parameter, γ-/γ+, which is a measure of the electron-donating capacity relative to the electron-accepting tendency of material. Lowering the work function value or increasing the γ-/γ+ ratio of the container material resulted in mannitol being more negatively charged, and vice versa. After charging, the powder was dispersed from an Aerolizer®, at 30 and 60 L/min, to study the aerosol performance. Irrespective of the charge level, the powder showed similar fine particle fraction, emitted dose and device retention at a given flow rate, indicating that charge induced by different containers during tumbling does not play a significant role in mannitol powder aerosolisation. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.acs.orgen_HK
dc.relation.ispartofJournal of Pharmaceutical Sciencesen_HK
dc.subjectAerosolen_HK
dc.subjectAgglomerateen_HK
dc.subjectDry powder inhalationen_HK
dc.subjectElectrostatic chargeen_HK
dc.subjectMannitolen_HK
dc.subjectSurface energyen_HK
dc.titleDoes electrostatic charge affect powder aerosolisation?en_HK
dc.typeArticleen_HK
dc.identifier.emailKwok, PCL: pclkwok@hku.hken_HK
dc.identifier.authorityKwok, PCL=rp01540en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jps.21996en_HK
dc.identifier.pmid19941330-
dc.identifier.scopuseid_2-s2.0-77951260970en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951260970&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue5en_HK
dc.identifier.spage2455en_HK
dc.identifier.epage2461en_HK
dc.identifier.eissn1520-6017-
dc.identifier.isiWOS:000277132500022-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAdi, H=24466627000en_HK
dc.identifier.scopusauthoridKwok, PCL=12646007800en_HK
dc.identifier.scopusauthoridCrapper, J=35423405300en_HK
dc.identifier.scopusauthoridYoung, PM=7402037987en_HK
dc.identifier.scopusauthoridTraini, D=10142464500en_HK
dc.identifier.scopusauthoridChan, HK=7403402677en_HK

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