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Article: Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: A mechanism for the pathogenesis of avian influenza H5N1 infection

TitleHyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: A mechanism for the pathogenesis of avian influenza H5N1 infection
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2008
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2008, v. 198 n. 4, p. 525-535 How to Cite?
Abstract
The mechanism for the pathogenesis of H5N1 infection in humans remains unclear. This study reveals that cyclooxygenase-2 (COX-2) was strongly induced in H5N1-infected macrophages in vitro and in epithelial cells of lung tissue samples obtained during autopsy of patients who died of H5N1 disease. Novel findings demonstrated that COX-2, along with tumor necrosis factor α and other proinflammatory cytokines were hyperinduced in epithelial cells by secretory factors from H5N1-infected macrophages in vitro. This amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. Furthermore, selective COX-2 inhibitors suppress the hyperinduction of cytokines in the proinflammatory cascade, indicating a regulatory role for COX-2 in the H5N1-hyperinduced host proinflammatory cascade. These data provide a basis for the possible development of novel therapeutic interventions for the treatment of H5N1 disease, as adjuncts to antiviral drugs. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141724
ISSN
2013 Impact Factor: 5.778
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, SMYen_HK
dc.contributor.authorCheung, CYen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorHui, KPYen_HK
dc.contributor.authorLeung, CYHen_HK
dc.contributor.authorUiprasertkul, Men_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorPoon, LLMen_HK
dc.contributor.authorIp, NYen_HK
dc.contributor.authorGuan, Yen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2011-09-27T02:59:25Z-
dc.date.available2011-09-27T02:59:25Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2008, v. 198 n. 4, p. 525-535en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141724-
dc.description.abstractThe mechanism for the pathogenesis of H5N1 infection in humans remains unclear. This study reveals that cyclooxygenase-2 (COX-2) was strongly induced in H5N1-infected macrophages in vitro and in epithelial cells of lung tissue samples obtained during autopsy of patients who died of H5N1 disease. Novel findings demonstrated that COX-2, along with tumor necrosis factor α and other proinflammatory cytokines were hyperinduced in epithelial cells by secretory factors from H5N1-infected macrophages in vitro. This amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. Furthermore, selective COX-2 inhibitors suppress the hyperinduction of cytokines in the proinflammatory cascade, indicating a regulatory role for COX-2 in the H5N1-hyperinduced host proinflammatory cascade. These data provide a basis for the possible development of novel therapeutic interventions for the treatment of H5N1 disease, as adjuncts to antiviral drugs. © 2008 by the Infectious Diseases Society of America. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.subjectChemicals And Cas Registry Numbersen_US
dc.subject.meshAnimalsen_HK
dc.subject.meshBirdsen_HK
dc.subject.meshCyclooxygenase 2 - biosynthesis - geneticsen_HK
dc.subject.meshCyclooxygenase 2 Inhibitorsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfluenza A Virus, H5N1 Subtype - genetics - immunology - pathogenicityen_HK
dc.subject.meshInfluenza in Birds - enzymology - immunology - virologyen_HK
dc.subject.meshInfluenza, Human - enzymology - virologyen_HK
dc.titleHyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: A mechanism for the pathogenesis of avian influenza H5N1 infectionen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SMY: suki@hku.hken_HK
dc.identifier.emailCheung, CY: chungey@hkucc.hku.hken_HK
dc.identifier.emailNicholls, JM: jmnichol@hkucc.hku.hken_HK
dc.identifier.emailLeung, CYH: cyhleung@hkucc.hku.hken_HK
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hken_HK
dc.identifier.emailLau, YL: lauylung@hku.hken_HK
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_HK
dc.identifier.emailGuan, Y: yguan@hkucc.hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityLee, SMY=rp01536en_HK
dc.identifier.authorityCheung, CY=rp00404en_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityLeung, CYH=rp00307en_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.identifier.authorityPoon, LLM=rp00484en_HK
dc.identifier.authorityGuan, Y=rp00397en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1086/590499en_HK
dc.identifier.pmid18613795en_HK
dc.identifier.scopuseid_2-s2.0-48749089085en_HK
dc.identifier.hkuros146550-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-48749089085&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume198en_HK
dc.identifier.issue4en_HK
dc.identifier.spage525en_HK
dc.identifier.epage535en_HK
dc.identifier.isiWOS:000257893300010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLee, SMY=35435155600en_HK
dc.identifier.scopusauthoridCheung, CY=7202061836en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridHui, KPY=24492032000en_HK
dc.identifier.scopusauthoridLeung, CYH=26531438300en_HK
dc.identifier.scopusauthoridUiprasertkul, M=6508217319en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridPoon, LLM=7005441747en_HK
dc.identifier.scopusauthoridIp, NY=7005756760en_HK
dc.identifier.scopusauthoridGuan, Y=7202924055en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK

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