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Article: Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro

TitleAntiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro
Authors
KeywordsAntiviral
H5N1
Influenza
Selective COX-2 inhibitor
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviral
Citation
Antiviral Research, 2011, v. 91 n. 3, p. 330-334 How to Cite?
AbstractA selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease. © 2011 Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/141717
ISSN
2015 Impact Factor: 4.909
2015 SCImago Journal Rankings: 2.080
ISI Accession Number ID
Funding AgencyGrant Number
Canadian Institutes of Health ResearchTPA-90195
Research Fund for Control of Infectious Diseases06060562
Research Grants CouncilHKU 773707M
University Grants Committee, Hong Kong SAR GovernmentAoE/M-12/06
Funding Information:

This work was supported by research grants from Canadian Institutes of Health Research (Reference No.: TPA-90195), Research Fund for Control of Infectious Diseases (Grant 06060562 to S.M.Y.L.), Research Grants Council (Grant HKU 773707M to J.S.M.P.) and AoE Funding (AoE/M-12/06) from the Area of Excellence Scheme of the University Grants Committee, Hong Kong SAR Government. We thank K.P. Mok, Department of Microbiology, The University of Hong Kong for providing the H9N2 virus strain used in this study.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLee, SMYen_HK
dc.contributor.authorGai, WWen_HK
dc.contributor.authorCheung, TKWen_HK
dc.contributor.authorPeiris, JSMen_HK
dc.date.accessioned2011-09-27T02:59:03Z-
dc.date.available2011-09-27T02:59:03Z-
dc.date.issued2011en_HK
dc.identifier.citationAntiviral Research, 2011, v. 91 n. 3, p. 330-334en_HK
dc.identifier.issn0166-3542en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141717-
dc.description.abstractA selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease. © 2011 Elsevier B.V.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/antiviralen_HK
dc.relation.ispartofAntiviral Researchen_HK
dc.subjectAntiviralen_HK
dc.subjectH5N1en_HK
dc.subjectInfluenzaen_HK
dc.subjectSelective COX-2 inhibitoren_HK
dc.subject.meshCyclooxygenase 2 - genetics - metabolism-
dc.subject.meshInfluenza A Virus, H5N1 Subtype - drug effects - physiology-
dc.subject.meshInfluenza, Human - drug therapy - virology-
dc.subject.meshMacrophages - cytology - drug effects - virology-
dc.subject.meshSignal Transduction - drug effects-
dc.titleAntiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitroen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, SMY: suki@hku.hken_HK
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_HK
dc.identifier.authorityLee, SMY=rp01536en_HK
dc.identifier.authorityPeiris, JSM=rp00410en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.antiviral.2011.07.011en_HK
dc.identifier.pmid21798291-
dc.identifier.scopuseid_2-s2.0-79961104264en_HK
dc.identifier.hkuros204662-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79961104264&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume91en_HK
dc.identifier.issue3en_HK
dc.identifier.spage330en_HK
dc.identifier.epage334en_HK
dc.identifier.eissn1872-9096-
dc.identifier.isiWOS:000294936800015-
dc.publisher.placeNetherlandsen_HK
dc.relation.projectEffector roles of cytokine cascades in the pathogenesis of human H5N1 disease-
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.relation.projectRole of cyclooxygenase-2 (COX-2) influenza A (subtype H5N1) viral pathogenesis and the potential use of its inhibitors for the therapy of H5N1 disease-
dc.identifier.scopusauthoridLee, SMY=35435155600en_HK
dc.identifier.scopusauthoridGai, WW=45661364100en_HK
dc.identifier.scopusauthoridCheung, TKW=16229531100en_HK
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_HK
dc.identifier.citeulike9647356-

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