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Article: Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis

TitleIsl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis
Authors
Issue Date2006
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
Citation
Developmental Biology, 2006, v. 295 n. 2, p. 756-763 How to Cite?
AbstractThe LIM homeodomain transcription factor Islet1 (Isl1) is expressed in both foregut endoderm and cardiogenic mesoderm and is required for earliest stages of heart development. Here, we report that isl1 is also required upstream of Shh. We find that, in isl1 null mice, Sonic hedgehog (Shh) is downregulated in foregut endoderm. Shh signals through the unique activating receptor smoothened (Smo). To investigate the role of hedgehog signaling in the isl1 domain, we ablated smo utilizing isl1-cre. Isl1-cre;smo mutants exhibit cardiovascular defects similar to those observed in Shh null mice, defining a spatial requirement for hedgehog signaling within isl1 expression domains for aortic arch and outflow tract formation. Semaphorin signaling through neuropilin receptors npn1 and npn2 is required for aortic arch and outflow tract formation. We find that expression of npn2 is downregulated in isl1-cre;smo mutants, suggesting an isl1/Shh/npn pathway required to affect morphogenesis at the anterior pole of the heart. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141714
ISSN
2015 Impact Factor: 3.155
2015 SCImago Journal Rankings: 2.554
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, Len_HK
dc.contributor.authorBu, Len_HK
dc.contributor.authorCai, CLen_HK
dc.contributor.authorZhang, Xen_HK
dc.contributor.authorEvans, Sen_HK
dc.date.accessioned2011-09-27T02:58:45Z-
dc.date.available2011-09-27T02:58:45Z-
dc.date.issued2006en_HK
dc.identifier.citationDevelopmental Biology, 2006, v. 295 n. 2, p. 756-763en_HK
dc.identifier.issn0012-1606en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141714-
dc.description.abstractThe LIM homeodomain transcription factor Islet1 (Isl1) is expressed in both foregut endoderm and cardiogenic mesoderm and is required for earliest stages of heart development. Here, we report that isl1 is also required upstream of Shh. We find that, in isl1 null mice, Sonic hedgehog (Shh) is downregulated in foregut endoderm. Shh signals through the unique activating receptor smoothened (Smo). To investigate the role of hedgehog signaling in the isl1 domain, we ablated smo utilizing isl1-cre. Isl1-cre;smo mutants exhibit cardiovascular defects similar to those observed in Shh null mice, defining a spatial requirement for hedgehog signaling within isl1 expression domains for aortic arch and outflow tract formation. Semaphorin signaling through neuropilin receptors npn1 and npn2 is required for aortic arch and outflow tract formation. We find that expression of npn2 is downregulated in isl1-cre;smo mutants, suggesting an isl1/Shh/npn pathway required to affect morphogenesis at the anterior pole of the heart. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbioen_HK
dc.relation.ispartofDevelopmental Biologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAorta, Thoracicen_HK
dc.subject.meshCardiovascular Abnormalities - etiologyen_HK
dc.subject.meshHeart - embryologyen_HK
dc.subject.meshHedgehog Proteinsen_HK
dc.subject.meshHomeodomain Proteins - metabolism - physiologyen_HK
dc.subject.meshLIM-Homeodomain Proteinsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Knockouten_HK
dc.subject.meshMorphogenesisen_HK
dc.subject.meshNerve Tissue Proteins - deficiency - metabolism - physiologyen_HK
dc.subject.meshNeuropilin-1 - metabolismen_HK
dc.subject.meshNeuropilin-2en_HK
dc.subject.meshNeuropilinsen_HK
dc.subject.meshReceptors, G-Protein-Coupleden_HK
dc.subject.meshSemaphorinsen_HK
dc.subject.meshTrans-Activators - metabolism - physiologyen_HK
dc.subject.meshTranscription Factorsen_HK
dc.titleIsl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesisen_HK
dc.typeArticleen_HK
dc.identifier.emailBu, L:leibu@hku.hken_HK
dc.identifier.authorityBu, L=rp01534en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ydbio.2006.03.053en_HK
dc.identifier.pmid16687132-
dc.identifier.scopuseid_2-s2.0-33745267057en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745267057&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume295en_HK
dc.identifier.issue2en_HK
dc.identifier.spage756en_HK
dc.identifier.epage763en_HK
dc.identifier.isiWOS:000239127700024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLin, L=13606302000en_HK
dc.identifier.scopusauthoridBu, L=8510445400en_HK
dc.identifier.scopusauthoridCai, CL=7202874136en_HK
dc.identifier.scopusauthoridZhang, X=8510445700en_HK
dc.identifier.scopusauthoridEvans, S=35583946900en_HK

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