File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Multipotent Embryonic Isl1 + Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification

TitleMultipotent Embryonic Isl1 + Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification
Authors
Issue Date2006
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/cell
Citation
Cell, 2006, v. 127 n. 6, p. 1151-1165 How to Cite?
AbstractCardiogenesis requires the generation of endothelial, cardiac, and smooth muscle cells, thought to arise from distinct embryonic precursors. We use genetic fate-mapping studies to document that isl1 + precursors from the second heart field can generate each of these diverse cardiovascular cell types in vivo. Utilizing embryonic stem (ES) cells, we clonally amplified a cellular hierarchy of isl1 + cardiovascular progenitors, which resemble the developmental precursors in the embryonic heart. The transcriptional signature of isl1 +/Nkx2.5 +/flk1 + defines a multipotent cardiovascular progenitor, which can give rise to cells of all three lineages. These studies document a developmental paradigm for cardiogenesis, where muscle and endothelial lineage diversification arises from a single cell-level decision of a multipotent isl1 + cardiovascular progenitor cell (MICP). The discovery of ES cell-derived MICPs suggests a strategy for cardiovascular tissue regeneration via their isolation, renewal, and directed differentiation into specific mature cardiac, pacemaker, smooth muscle, and endothelial cell types. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141713
ISSN
2015 Impact Factor: 28.71
2015 SCImago Journal Rankings: 28.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMoretti, Aen_HK
dc.contributor.authorCaron, Len_HK
dc.contributor.authorNakano, Aen_HK
dc.contributor.authorLam, JTen_HK
dc.contributor.authorBernshausen, Aen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorQyang, Yen_HK
dc.contributor.authorBu, Len_HK
dc.contributor.authorSasaki, Men_HK
dc.contributor.authorMartinPuig, Sen_HK
dc.contributor.authorSun, Yen_HK
dc.contributor.authorEvans, SMen_HK
dc.contributor.authorLaugwitz, KLen_HK
dc.contributor.authorChien, KRen_HK
dc.date.accessioned2011-09-27T02:58:44Z-
dc.date.available2011-09-27T02:58:44Z-
dc.date.issued2006en_HK
dc.identifier.citationCell, 2006, v. 127 n. 6, p. 1151-1165en_HK
dc.identifier.issn0092-8674en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141713-
dc.description.abstractCardiogenesis requires the generation of endothelial, cardiac, and smooth muscle cells, thought to arise from distinct embryonic precursors. We use genetic fate-mapping studies to document that isl1 + precursors from the second heart field can generate each of these diverse cardiovascular cell types in vivo. Utilizing embryonic stem (ES) cells, we clonally amplified a cellular hierarchy of isl1 + cardiovascular progenitors, which resemble the developmental precursors in the embryonic heart. The transcriptional signature of isl1 +/Nkx2.5 +/flk1 + defines a multipotent cardiovascular progenitor, which can give rise to cells of all three lineages. These studies document a developmental paradigm for cardiogenesis, where muscle and endothelial lineage diversification arises from a single cell-level decision of a multipotent isl1 + cardiovascular progenitor cell (MICP). The discovery of ES cell-derived MICPs suggests a strategy for cardiovascular tissue regeneration via their isolation, renewal, and directed differentiation into specific mature cardiac, pacemaker, smooth muscle, and endothelial cell types. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/cellen_HK
dc.relation.ispartofCellen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Culture Techniquesen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshCell Lineageen_HK
dc.subject.meshClone Cellsen_HK
dc.subject.meshEmbryonic Stem Cells - physiologyen_HK
dc.subject.meshEndothelial Cells - cytologyen_HK
dc.subject.meshHeart - embryologyen_HK
dc.subject.meshHeterozygoteen_HK
dc.subject.meshHomeodomain Proteins - geneticsen_HK
dc.subject.meshLIM-Homeodomain Proteinsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred Strainsen_HK
dc.subject.meshMultipotent Stem Cells - physiologyen_HK
dc.subject.meshMyocardium - cytologyen_HK
dc.subject.meshMyocytes, Cardiac - cytologyen_HK
dc.subject.meshMyocytes, Smooth Muscle - cytologyen_HK
dc.subject.meshTranscription Factorsen_HK
dc.titleMultipotent Embryonic Isl1 + Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversificationen_HK
dc.typeArticleen_HK
dc.identifier.emailBu, L:leibu@hku.hken_HK
dc.identifier.authorityBu, L=rp01534en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.cell.2006.10.029en_HK
dc.identifier.pmid17123592-
dc.identifier.scopuseid_2-s2.0-33845457194en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845457194&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume127en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1151en_HK
dc.identifier.epage1165en_HK
dc.identifier.isiWOS:000242991000014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001100314-
dc.identifier.scopusauthoridMoretti, A=7103036277en_HK
dc.identifier.scopusauthoridCaron, L=7006626672en_HK
dc.identifier.scopusauthoridNakano, A=32267442500en_HK
dc.identifier.scopusauthoridLam, JT=7201973317en_HK
dc.identifier.scopusauthoridBernshausen, A=6504080526en_HK
dc.identifier.scopusauthoridChen, Y=7601445170en_HK
dc.identifier.scopusauthoridQyang, Y=6506533054en_HK
dc.identifier.scopusauthoridBu, L=8510445400en_HK
dc.identifier.scopusauthoridSasaki, M=15137330300en_HK
dc.identifier.scopusauthoridMartinPuig, S=6508291981en_HK
dc.identifier.scopusauthoridSun, Y=7406431925en_HK
dc.identifier.scopusauthoridEvans, SM=35583946900en_HK
dc.identifier.scopusauthoridLaugwitz, KL=6603873440en_HK
dc.identifier.scopusauthoridChien, KR=35902336700en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats