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Article: The Renewal and Differentiation of Isl1 + Cardiovascular Progenitors Are Controlled by a Wnt/β-Catenin Pathway

TitleThe Renewal and Differentiation of Isl1 + Cardiovascular Progenitors Are Controlled by a Wnt/β-Catenin Pathway
Authors
Issue Date2007
PublisherCell Press. The Journal's web site is located at http://www.cellstemcell.com
Citation
Cell Stem Cell, 2007, v. 1 n. 2, p. 165-179 How to Cite?
AbstractIsl1 + cardiovascular progenitors and their downstream progeny play a pivotal role in cardiogenesis and lineage diversification of the heart. The mechanisms that control their renewal and differentiation are largely unknown. Herein, we show that the Wnt/β-catenin pathway is a major component by which cardiac mesenchymal cells modulate the prespecification, renewal, and differentiation of isl1 + cardiovascular progenitors. This microenvironment can be reconstituted by a Wnt3a-secreting feeder layer with ES cell-derived, embryonic, and postnatal isl1 + cardiovascular progenitors. In vivo activation of β-catenin signaling in isl1 + progenitors of the secondary heart field leads to their massive accumulation, inhibition of differentiation, and outflow tract (OFT) morphogenic defects. In addition, the mitosis rate in OFT myocytes is significantly reduced following β-catenin deletion in isl1 + precursors. Agents that manipulate Wnt signals can markedly expand isl1 + progenitors from human neonatal hearts, a key advance toward the cloning of human isl1 + heart progenitors. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141711
ISSN
2015 Impact Factor: 22.387
2015 SCImago Journal Rankings: 13.121
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQyang, Yen_HK
dc.contributor.authorMartinPuig, Sen_HK
dc.contributor.authorChiravuri, Men_HK
dc.contributor.authorChen, Sen_HK
dc.contributor.authorXu, Hen_HK
dc.contributor.authorBu, Len_HK
dc.contributor.authorJiang, Xen_HK
dc.contributor.authorLin, Len_HK
dc.contributor.authorGranger, Aen_HK
dc.contributor.authorMoretti, Aen_HK
dc.contributor.authorCaron, Len_HK
dc.contributor.authorWu, Xen_HK
dc.contributor.authorClarke, Jen_HK
dc.contributor.authorTaketo, MMen_HK
dc.contributor.authorLaugwitz, KLen_HK
dc.contributor.authorMoon, RTen_HK
dc.contributor.authorGruber, Pen_HK
dc.contributor.authorEvans, SMen_HK
dc.contributor.authorDing, Sen_HK
dc.contributor.authorChien, KennethRen_HK
dc.date.accessioned2011-09-27T02:58:40Z-
dc.date.available2011-09-27T02:58:40Z-
dc.date.issued2007en_HK
dc.identifier.citationCell Stem Cell, 2007, v. 1 n. 2, p. 165-179en_HK
dc.identifier.issn1934-5909en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141711-
dc.description.abstractIsl1 + cardiovascular progenitors and their downstream progeny play a pivotal role in cardiogenesis and lineage diversification of the heart. The mechanisms that control their renewal and differentiation are largely unknown. Herein, we show that the Wnt/β-catenin pathway is a major component by which cardiac mesenchymal cells modulate the prespecification, renewal, and differentiation of isl1 + cardiovascular progenitors. This microenvironment can be reconstituted by a Wnt3a-secreting feeder layer with ES cell-derived, embryonic, and postnatal isl1 + cardiovascular progenitors. In vivo activation of β-catenin signaling in isl1 + progenitors of the secondary heart field leads to their massive accumulation, inhibition of differentiation, and outflow tract (OFT) morphogenic defects. In addition, the mitosis rate in OFT myocytes is significantly reduced following β-catenin deletion in isl1 + precursors. Agents that manipulate Wnt signals can markedly expand isl1 + progenitors from human neonatal hearts, a key advance toward the cloning of human isl1 + heart progenitors. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.cellstemcell.comen_HK
dc.relation.ispartofCell Stem Cellen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCardiovascular System - cytology - embryologyen_HK
dc.subject.meshCell Differentiation - physiologyen_HK
dc.subject.meshCell Lineageen_HK
dc.subject.meshEmbryo, Mammalian - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHeart - embryology - physiologyen_HK
dc.subject.meshHeart Defects, Congenital - physiopathologyen_HK
dc.subject.meshHomeodomain Proteins - genetics - metabolism - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLIM-Homeodomain Proteinsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshSignal Transductionen_HK
dc.subject.meshStem Cells - cytology - physiologyen_HK
dc.subject.meshTranscription Factorsen_HK
dc.subject.meshWnt Proteins - genetics - metabolism - physiologyen_HK
dc.subject.meshbeta Catenin - genetics - metabolism - physiologyen_HK
dc.titleThe Renewal and Differentiation of Isl1 + Cardiovascular Progenitors Are Controlled by a Wnt/β-Catenin Pathwayen_HK
dc.typeArticleen_HK
dc.identifier.emailBu, L:leibu@hku.hken_HK
dc.identifier.authorityBu, L=rp01534en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.stem.2007.05.018en_HK
dc.identifier.pmid18371348-
dc.identifier.scopuseid_2-s2.0-34547796852en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547796852&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume1en_HK
dc.identifier.issue2en_HK
dc.identifier.spage165en_HK
dc.identifier.epage179en_HK
dc.identifier.isiWOS:000251055100008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridQyang, Y=6506533054en_HK
dc.identifier.scopusauthoridMartinPuig, S=6508291981en_HK
dc.identifier.scopusauthoridChiravuri, M=6507265662en_HK
dc.identifier.scopusauthoridChen, S=7410256908en_HK
dc.identifier.scopusauthoridXu, H=9041174600en_HK
dc.identifier.scopusauthoridBu, L=8510445400en_HK
dc.identifier.scopusauthoridJiang, X=55187615600en_HK
dc.identifier.scopusauthoridLin, L=13606302000en_HK
dc.identifier.scopusauthoridGranger, A=7003599223en_HK
dc.identifier.scopusauthoridMoretti, A=7103036277en_HK
dc.identifier.scopusauthoridCaron, L=7006626672en_HK
dc.identifier.scopusauthoridWu, X=7407058901en_HK
dc.identifier.scopusauthoridClarke, J=36888434200en_HK
dc.identifier.scopusauthoridTaketo, MM=7004878460en_HK
dc.identifier.scopusauthoridLaugwitz, KL=6603873440en_HK
dc.identifier.scopusauthoridMoon, RT=7202316413en_HK
dc.identifier.scopusauthoridGruber, P=7006614042en_HK
dc.identifier.scopusauthoridEvans, SM=35583946900en_HK
dc.identifier.scopusauthoridDing, S=21833396700en_HK
dc.identifier.scopusauthoridChien, KennethR=35902336700en_HK

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