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Article: A myocardial lineage derives from Tbx18 epicardial cells

TitleA myocardial lineage derives from Tbx18 epicardial cells
Authors
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2008, v. 454 n. 7200, p. 104-108 How to Cite?
AbstractUnderstanding the origins and roles of cardiac progenitor cells is important for elucidating the pathogenesis of congenital and acquired heart diseases. Moreover, manipulation of cardiac myocyte progenitors has potential for cell-based repair strategies for various myocardial disorders. Here we report the identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ. These progenitor cells, which express the T-box transcription factor Tbx18, migrate onto the outer cardiac surface to form the epicardium, and then make a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Tbx18-expressing cardiac progenitors also give rise to cardiac fibroblasts and coronary smooth muscle cells. The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration. ©2008 Macmillan Publishers Limited. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141710
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCai, CLen_HK
dc.contributor.authorMartin, JCen_HK
dc.contributor.authorSun, Yen_HK
dc.contributor.authorCui, Len_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorOuyang, Ken_HK
dc.contributor.authorYang, Len_HK
dc.contributor.authorBu, Len_HK
dc.contributor.authorLiang, Xen_HK
dc.contributor.authorZhang, Xen_HK
dc.contributor.authorStallcup, WBen_HK
dc.contributor.authorDenton, CPen_HK
dc.contributor.authorMcCulloch, Aen_HK
dc.contributor.authorChen, Jen_HK
dc.contributor.authorEvans, SMen_HK
dc.date.accessioned2011-09-27T02:58:39Z-
dc.date.available2011-09-27T02:58:39Z-
dc.date.issued2008en_HK
dc.identifier.citationNature, 2008, v. 454 n. 7200, p. 104-108en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141710-
dc.description.abstractUnderstanding the origins and roles of cardiac progenitor cells is important for elucidating the pathogenesis of congenital and acquired heart diseases. Moreover, manipulation of cardiac myocyte progenitors has potential for cell-based repair strategies for various myocardial disorders. Here we report the identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ. These progenitor cells, which express the T-box transcription factor Tbx18, migrate onto the outer cardiac surface to form the epicardium, and then make a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Tbx18-expressing cardiac progenitors also give rise to cardiac fibroblasts and coronary smooth muscle cells. The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration. ©2008 Macmillan Publishers Limited. All rights reserved.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNatureen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshCell Lineageen_HK
dc.subject.meshGene Expression Regulation, Developmentalen_HK
dc.subject.meshHeart - growth & developmenten_HK
dc.subject.meshLac Operon - geneticsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMyocardium - cytology - metabolismen_HK
dc.subject.meshMyocytes, Cardiac - cytology - metabolismen_HK
dc.subject.meshMyocytes, Smooth Muscle - metabolismen_HK
dc.subject.meshPericardium - cytology - metabolismen_HK
dc.subject.meshStem Cells - cytology - metabolismen_HK
dc.subject.meshT-Box Domain Proteins - genetics - metabolismen_HK
dc.titleA myocardial lineage derives from Tbx18 epicardial cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailBu, L:leibu@hku.hken_HK
dc.identifier.authorityBu, L=rp01534en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/nature06969en_HK
dc.identifier.pmid18480752en_HK
dc.identifier.scopuseid_2-s2.0-46449089721en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-46449089721&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume454en_HK
dc.identifier.issue7200en_HK
dc.identifier.spage104en_HK
dc.identifier.epage108en_HK
dc.identifier.eissn1476-4687-
dc.identifier.isiWOS:000257308300046-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCai, CL=7202874136en_HK
dc.identifier.scopusauthoridMartin, JC=7501557320en_HK
dc.identifier.scopusauthoridSun, Y=7406431925en_HK
dc.identifier.scopusauthoridCui, L=36518491200en_HK
dc.identifier.scopusauthoridWang, L=8751939700en_HK
dc.identifier.scopusauthoridOuyang, K=8907630300en_HK
dc.identifier.scopusauthoridYang, L=8303959000en_HK
dc.identifier.scopusauthoridBu, L=8510445400en_HK
dc.identifier.scopusauthoridLiang, X=7401735895en_HK
dc.identifier.scopusauthoridZhang, X=8510445700en_HK
dc.identifier.scopusauthoridStallcup, WB=7006648244en_HK
dc.identifier.scopusauthoridDenton, CP=7006031021en_HK
dc.identifier.scopusauthoridMcCulloch, A=7102710961en_HK
dc.identifier.scopusauthoridChen, J=7501887040en_HK
dc.identifier.scopusauthoridEvans, SM=35583946900en_HK
dc.identifier.citeulike2802889-

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