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Article: The Effect of Tranexamic Acid on Blood Loss During Orthognathic Surgery: A Randomized Controlled Trial

TitleThe Effect of Tranexamic Acid on Blood Loss During Orthognathic Surgery: A Randomized Controlled Trial
Authors
Issue Date2009
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
Citation
Journal Of Oral And Maxillofacial Surgery, 2009, v. 67 n. 1, p. 125-133 How to Cite?
AbstractPurpose: Tranexamic acid has been used to reduce blood loss and the subsequent need for transfusion in orthopedic, spinal, and cardiac surgery. Orthognathic surgery can be associated with significant bleeding yet its efficacy in this setting is not clear. The purpose of this study was to investigate the effect of tranexamic acid on blood loss during bimaxillary osteotomy. Patients and Methods: Seventy-three consecutive patients, scheduled for elective bimaxillary osteotomy, were included in this double blind, randomized, controlled trial. They received either a bolus of tranexamic acid (20 mg/kg) or placebo (normal saline) intravenously just before surgery. All patients received induced mild hypotension and had surgery according to a standard protocol. Intraoperative blood loss, operation time, transfusion of blood products, perioperative hemoglobin, and hematocrit were recorded. Results: The total blood loss and blood loss during maxillary surgery was reduced significantly in the tranexamic acid group compared with the control group (878.6 ± 577.7 mL vs 1,257.2 ± 817.8 mL and 428.0 ± 233.3 mL vs 643.8 ± 430.0 mL, respectively; P < .05). Considering the duration of operation and the treatment groups only, the mean total blood loss in the control group was 422 mL more than that in the tranexamic acid group (P < .001). There was no significant difference in blood transfusion or the length of hospital stay between the 2 groups. Conclusion: Preoperative intravenous bolus administration of tranexamic acid at 20 mg/kg reduces blood loss compared with placebo during bimaxillary osteotomy. © 2009 American Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/141686
ISSN
2015 Impact Factor: 1.631
2015 SCImago Journal Rankings: 0.824
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChoi, WSen_HK
dc.contributor.authorIrwin, MGen_HK
dc.contributor.authorSamman, Nen_HK
dc.date.accessioned2011-09-27T02:58:01Z-
dc.date.available2011-09-27T02:58:01Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2009, v. 67 n. 1, p. 125-133en_HK
dc.identifier.issn0278-2391en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141686-
dc.description.abstractPurpose: Tranexamic acid has been used to reduce blood loss and the subsequent need for transfusion in orthopedic, spinal, and cardiac surgery. Orthognathic surgery can be associated with significant bleeding yet its efficacy in this setting is not clear. The purpose of this study was to investigate the effect of tranexamic acid on blood loss during bimaxillary osteotomy. Patients and Methods: Seventy-three consecutive patients, scheduled for elective bimaxillary osteotomy, were included in this double blind, randomized, controlled trial. They received either a bolus of tranexamic acid (20 mg/kg) or placebo (normal saline) intravenously just before surgery. All patients received induced mild hypotension and had surgery according to a standard protocol. Intraoperative blood loss, operation time, transfusion of blood products, perioperative hemoglobin, and hematocrit were recorded. Results: The total blood loss and blood loss during maxillary surgery was reduced significantly in the tranexamic acid group compared with the control group (878.6 ± 577.7 mL vs 1,257.2 ± 817.8 mL and 428.0 ± 233.3 mL vs 643.8 ± 430.0 mL, respectively; P < .05). Considering the duration of operation and the treatment groups only, the mean total blood loss in the control group was 422 mL more than that in the tranexamic acid group (P < .001). There was no significant difference in blood transfusion or the length of hospital stay between the 2 groups. Conclusion: Preoperative intravenous bolus administration of tranexamic acid at 20 mg/kg reduces blood loss compared with placebo during bimaxillary osteotomy. © 2009 American Association of Oral and Maxillofacial Surgeons.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jomsen_HK
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAntifibrinolytic Agents - therapeutic useen_HK
dc.subject.meshBlood Loss, Surgical - prevention & controlen_HK
dc.subject.meshDouble-Blind Methoden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHemodynamics - drug effectsen_HK
dc.subject.meshHemostatics - therapeutic useen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypotension - chemically induceden_HK
dc.subject.meshMaleen_HK
dc.subject.meshMaxilla - surgeryen_HK
dc.subject.meshOsteotomy - adverse effects - methodsen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.subject.meshTranexamic Acid - therapeutic useen_HK
dc.subject.meshYoung Adulten_HK
dc.titleThe Effect of Tranexamic Acid on Blood Loss During Orthognathic Surgery: A Randomized Controlled Trialen_HK
dc.typeArticleen_HK
dc.identifier.emailChoi, WS:drwchoi@hku.hken_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.emailSamman, N:nsamman@hkucc.hku.hken_HK
dc.identifier.authorityChoi, WS=rp01521en_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.identifier.authoritySamman, N=rp00021en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.joms.2008.08.015en_HK
dc.identifier.pmid19070758-
dc.identifier.scopuseid_2-s2.0-57349105193en_HK
dc.identifier.hkuros156075-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57349105193&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume67en_HK
dc.identifier.issue1en_HK
dc.identifier.spage125en_HK
dc.identifier.epage133en_HK
dc.identifier.eissn1531-5053-
dc.identifier.isiWOS:000261981700019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChoi, WS=25824732000en_HK
dc.identifier.scopusauthoridIrwin, MG=7202411076en_HK
dc.identifier.scopusauthoridSamman, N=7006413627en_HK

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