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Article: Evaluation of the analgesic efficacy of local dexmedetomidine application

TitleEvaluation of the analgesic efficacy of local dexmedetomidine application
Authors
KeywordsAnalgesia
dental
dexmedetomidine
local
pain
Issue Date2011
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.clinicalpain.com
Citation
Clinical Journal Of Pain, 2011, v. 27 n. 5, p. 377-382 How to Cite?
AbstractObjectives: To determine the analgesic effects of locally applied dexmedetomidine in third molar surgery under general anesthesia. Methods: Patients undergoing bilateral third molar surgery under general anesthesia were recruited into this double-blind, randomized, controlled study and were allocated to 3 study groups. Group D received preincision intravenous dexmedetomidine (1 mcg/kg) and direct infiltration of normal saline to the surgical wounds at the end of the surgery. Group P received preincision intravenous normal saline and direct infiltration of dexmedetomidine (1 μg /kg) to the surgical wounds at the end of the surgery. A control group (group N) received normal saline at both time points. Postoperative analgesic effects, analgesic consumption, global pain satisfaction score, vital signs, adverse events, and postoperative recovery were assessed. Results: Thirty-three patients from each group were studied. Postoperative resting pain numerical rating scale scores were similar in all the groups. However, the areas under curves of numerical rating scale pain scores during mouth opening for 1 to 72 hours were significantly lower in group P than in group N (P=0.012). Both heart rate and systolic blood pressure in the immediate postoperative period were significantly lower in groups D and P than in group N (P<0.001). Patients from groups D and P were also more sedated than patients in group N (P=0.013 and P=0.007, respectively) but no difference in psychomotor recovery was observed. Respiratory rate, oxygen saturation, common side effects, wound infection rate, and global pain satisfaction scores were similar among the groups. Conclusions: Dexmedetomidine seems to have an antihyperalgesic effect when administered locally after bilateral third molar surgery. There is no delay in psychomotor recovery or increase in postoperative clinically significant adverse events. Copyright © 2011 by Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/141684
ISSN
2015 Impact Factor: 2.712
2015 SCImago Journal Rankings: 1.111
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong200807176008
Funding Information:

Supported in part by the University of Hong Kong CRCG Small Project Fund (200807176008).

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CWen_HK
dc.contributor.authorJacobus Ng, KFen_HK
dc.contributor.authorChoi, WSen_HK
dc.contributor.authorChiu, WKen_HK
dc.contributor.authorYing, ACLen_HK
dc.contributor.authorIrwin, MGen_HK
dc.date.accessioned2011-09-27T02:57:57Z-
dc.date.available2011-09-27T02:57:57Z-
dc.date.issued2011en_HK
dc.identifier.citationClinical Journal Of Pain, 2011, v. 27 n. 5, p. 377-382en_HK
dc.identifier.issn0749-8047en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141684-
dc.description.abstractObjectives: To determine the analgesic effects of locally applied dexmedetomidine in third molar surgery under general anesthesia. Methods: Patients undergoing bilateral third molar surgery under general anesthesia were recruited into this double-blind, randomized, controlled study and were allocated to 3 study groups. Group D received preincision intravenous dexmedetomidine (1 mcg/kg) and direct infiltration of normal saline to the surgical wounds at the end of the surgery. Group P received preincision intravenous normal saline and direct infiltration of dexmedetomidine (1 μg /kg) to the surgical wounds at the end of the surgery. A control group (group N) received normal saline at both time points. Postoperative analgesic effects, analgesic consumption, global pain satisfaction score, vital signs, adverse events, and postoperative recovery were assessed. Results: Thirty-three patients from each group were studied. Postoperative resting pain numerical rating scale scores were similar in all the groups. However, the areas under curves of numerical rating scale pain scores during mouth opening for 1 to 72 hours were significantly lower in group P than in group N (P=0.012). Both heart rate and systolic blood pressure in the immediate postoperative period were significantly lower in groups D and P than in group N (P<0.001). Patients from groups D and P were also more sedated than patients in group N (P=0.013 and P=0.007, respectively) but no difference in psychomotor recovery was observed. Respiratory rate, oxygen saturation, common side effects, wound infection rate, and global pain satisfaction scores were similar among the groups. Conclusions: Dexmedetomidine seems to have an antihyperalgesic effect when administered locally after bilateral third molar surgery. There is no delay in psychomotor recovery or increase in postoperative clinically significant adverse events. Copyright © 2011 by Lippincott Williams & Wilkins.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.clinicalpain.comen_HK
dc.relation.ispartofClinical Journal of Painen_HK
dc.subjectAnalgesiaen_HK
dc.subjectdentalen_HK
dc.subjectdexmedetomidineen_HK
dc.subjectlocalen_HK
dc.subjectpainen_HK
dc.subject.meshDexmedetomidine - administration and dosage-
dc.subject.meshPain, Postoperative - diagnosis - prevention and control-
dc.subject.meshTooth Extraction - adverse effects-
dc.subject.meshAnalgesia-
dc.subject.meshDental surgery-
dc.titleEvaluation of the analgesic efficacy of local dexmedetomidine applicationen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, CW:cheucw@hku.hken_HK
dc.identifier.emailJacobus Ng, KF:jkfng@hkucc.hku.hken_HK
dc.identifier.emailChoi, WS:drwchoi@hku.hken_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.authorityCheung, CW=rp00244en_HK
dc.identifier.authorityJacobus Ng, KF=rp00544en_HK
dc.identifier.authorityChoi, WS=rp01521en_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/AJP.0b013e318208c8c5en_HK
dc.identifier.pmid21317777-
dc.identifier.scopuseid_2-s2.0-79955814175en_HK
dc.identifier.hkuros192024-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79955814175&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue5en_HK
dc.identifier.spage377en_HK
dc.identifier.epage382en_HK
dc.identifier.eissn1536-5409-
dc.identifier.isiWOS:000290434100001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, CW=24754835800en_HK
dc.identifier.scopusauthoridJacobus Ng, KF=13608809400en_HK
dc.identifier.scopusauthoridChoi, WS=25824732000en_HK
dc.identifier.scopusauthoridChiu, WK=36177164400en_HK
dc.identifier.scopusauthoridAaron Ying, CL=36961076500en_HK
dc.identifier.scopusauthoridIrwin, MG=7202411076en_HK

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