Article: A double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia

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TitleA double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia
AuthorsCheung, CW1
Choi, WS2
Leung, YY2
Lui, F3
Ng, JKF1
HeiHo, AM4
Irwin, MG1
Issue Date2012
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
CitationJournal Of Oral And Maxillofacial Surgery, 2012, v. 70 n. 1, p. 25-30 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.joms.2011.03.056
AbstractThis double-blind randomized crossover study compared the analgesic efficacy of pre- and postoperative administration of oral pregabalin 75 mg using a postsurgical dental pain model. Patients requiring third molar surgery in 2 separate stages under local anesthesia were recruited. They were given pregabalin 75 mg either 1 hour before or after their first surgical extraction. They then received the same dose of pregabalin at their second surgical extraction, but those who received it before surgery received it postsurgery, and vice versa. Postoperative analgesic effects were assessed at postoperative hours 2, 4, 8, 12, 24, 48, and 72. Time to first analgesic, analgesic consumption and adverse events were also evaluated. Forty patients were recruited, and 34 completed the study. The area under curves for numerical rating scale pain scores 1 to 24 hours were significantly lower at rest but not during mouth opening for patients receiving postoperative pregabalin (P <.048). Pain relief was similar for the period of 24 to 72 hours. No significant difference was found in time to first analgesic, total analgesic consumption, and side effects between preoperative and postoperative groups. No difference in the incidence of adverse events was noticed in relation to the timing of pregabalin administration. Postoperative administration of oral pregabalin 75 mg appears to offer better analgesic efficacy than preoperative administration after third molar surgery under local anesthesia. © 2012 American Association of Oral and Maxillofacial Surgeons.
DescriptionEpub ahead of print
ISSN0278-2391
2011 Impact Factor: 1.64
2011 SCImago Journal Rankings: 0.096
DOIhttp://dx.doi.org/10.1016/j.joms.2011.03.056
ISI Accession Number IDWOS:000299214500025
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, CW
dc.contributor.authorChoi, WS
dc.contributor.authorLeung, YY
dc.contributor.authorLui, F
dc.contributor.authorNg, JKF
dc.contributor.authorHeiHo, AM
dc.contributor.authorIrwin, MG
dc.date.accessioned2011-09-27T02:57:41Z
dc.date.available2011-09-27T02:57:41Z
dc.date.issued2012
dc.description.abstractThis double-blind randomized crossover study compared the analgesic efficacy of pre- and postoperative administration of oral pregabalin 75 mg using a postsurgical dental pain model. Patients requiring third molar surgery in 2 separate stages under local anesthesia were recruited. They were given pregabalin 75 mg either 1 hour before or after their first surgical extraction. They then received the same dose of pregabalin at their second surgical extraction, but those who received it before surgery received it postsurgery, and vice versa. Postoperative analgesic effects were assessed at postoperative hours 2, 4, 8, 12, 24, 48, and 72. Time to first analgesic, analgesic consumption and adverse events were also evaluated. Forty patients were recruited, and 34 completed the study. The area under curves for numerical rating scale pain scores 1 to 24 hours were significantly lower at rest but not during mouth opening for patients receiving postoperative pregabalin (P <.048). Pain relief was similar for the period of 24 to 72 hours. No significant difference was found in time to first analgesic, total analgesic consumption, and side effects between preoperative and postoperative groups. No difference in the incidence of adverse events was noticed in relation to the timing of pregabalin administration. Postoperative administration of oral pregabalin 75 mg appears to offer better analgesic efficacy than preoperative administration after third molar surgery under local anesthesia. © 2012 American Association of Oral and Maxillofacial Surgeons.
dc.description.naturelink_to_subscribed_fulltext
dc.descriptionEpub ahead of print
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2012, v. 70 n. 1, p. 25-30 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.joms.2011.03.056
dc.identifier.doihttp://dx.doi.org/10.1016/j.joms.2011.03.056
dc.identifier.epage30
dc.identifier.hkuros193534
dc.identifier.isiWOS:000299214500025
dc.identifier.issn0278-2391
2011 Impact Factor: 1.64
2011 SCImago Journal Rankings: 0.096
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid21820233
dc.identifier.scopuseid_2-s2.0-84355161763
dc.identifier.spage25
dc.identifier.urihttp://hdl.handle.net/10722/141677
dc.identifier.volume70
dc.languageeng
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Oral and Maxillofacial Surgery
dc.relation.referencesReferences in Scopus
dc.titleA double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Queen Mary Hospital Hong Kong
  4. Chinese University of Hong Kong