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Article: A double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia
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TitleA double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia
 
AuthorsCheung, CW1
Choi, WS2
Leung, YY2
Lui, F3
Ng, JKF1
HeiHo, AM4
Irwin, MG1
 
Issue Date2012
 
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
 
CitationJournal Of Oral And Maxillofacial Surgery, 2012, v. 70 n. 1, p. 25-30 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.joms.2011.03.056
 
AbstractThis double-blind randomized crossover study compared the analgesic efficacy of pre- and postoperative administration of oral pregabalin 75 mg using a postsurgical dental pain model. Patients requiring third molar surgery in 2 separate stages under local anesthesia were recruited. They were given pregabalin 75 mg either 1 hour before or after their first surgical extraction. They then received the same dose of pregabalin at their second surgical extraction, but those who received it before surgery received it postsurgery, and vice versa. Postoperative analgesic effects were assessed at postoperative hours 2, 4, 8, 12, 24, 48, and 72. Time to first analgesic, analgesic consumption and adverse events were also evaluated. Forty patients were recruited, and 34 completed the study. The area under curves for numerical rating scale pain scores 1 to 24 hours were significantly lower at rest but not during mouth opening for patients receiving postoperative pregabalin (P <.048). Pain relief was similar for the period of 24 to 72 hours. No significant difference was found in time to first analgesic, total analgesic consumption, and side effects between preoperative and postoperative groups. No difference in the incidence of adverse events was noticed in relation to the timing of pregabalin administration. Postoperative administration of oral pregabalin 75 mg appears to offer better analgesic efficacy than preoperative administration after third molar surgery under local anesthesia. © 2012 American Association of Oral and Maxillofacial Surgeons.
 
DescriptionEpub ahead of print
 
ISSN0278-2391
2013 Impact Factor: 1.280
 
DOIhttp://dx.doi.org/10.1016/j.joms.2011.03.056
 
ISI Accession Number IDWOS:000299214500025
 
ReferencesReferences in Scopus
 
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dc.contributor.authorCheung, CW
 
dc.contributor.authorChoi, WS
 
dc.contributor.authorLeung, YY
 
dc.contributor.authorLui, F
 
dc.contributor.authorNg, JKF
 
dc.contributor.authorHeiHo, AM
 
dc.contributor.authorIrwin, MG
 
dc.date.accessioned2011-09-27T02:57:41Z
 
dc.date.available2011-09-27T02:57:41Z
 
dc.date.issued2012
 
dc.description.abstractThis double-blind randomized crossover study compared the analgesic efficacy of pre- and postoperative administration of oral pregabalin 75 mg using a postsurgical dental pain model. Patients requiring third molar surgery in 2 separate stages under local anesthesia were recruited. They were given pregabalin 75 mg either 1 hour before or after their first surgical extraction. They then received the same dose of pregabalin at their second surgical extraction, but those who received it before surgery received it postsurgery, and vice versa. Postoperative analgesic effects were assessed at postoperative hours 2, 4, 8, 12, 24, 48, and 72. Time to first analgesic, analgesic consumption and adverse events were also evaluated. Forty patients were recruited, and 34 completed the study. The area under curves for numerical rating scale pain scores 1 to 24 hours were significantly lower at rest but not during mouth opening for patients receiving postoperative pregabalin (P <.048). Pain relief was similar for the period of 24 to 72 hours. No significant difference was found in time to first analgesic, total analgesic consumption, and side effects between preoperative and postoperative groups. No difference in the incidence of adverse events was noticed in relation to the timing of pregabalin administration. Postoperative administration of oral pregabalin 75 mg appears to offer better analgesic efficacy than preoperative administration after third molar surgery under local anesthesia. © 2012 American Association of Oral and Maxillofacial Surgeons.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.descriptionEpub ahead of print
 
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2012, v. 70 n. 1, p. 25-30 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.joms.2011.03.056
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.joms.2011.03.056
 
dc.identifier.eissn1531-5053
 
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dc.identifier.hkuros193534
 
dc.identifier.hkuros228599
 
dc.identifier.isiWOS:000299214500025
 
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2013 Impact Factor: 1.280
 
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dc.identifier.urihttp://hdl.handle.net/10722/141677
 
dc.identifier.volume70
 
dc.languageeng
 
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Oral and Maxillofacial Surgery
 
dc.relation.referencesReferences in Scopus
 
dc.titleA double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Queen Mary Hospital Hong Kong
  4. Chinese University of Hong Kong