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Article: A double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia

TitleA double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia
Authors
Issue Date2012
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
Citation
Journal Of Oral And Maxillofacial Surgery, 2012, v. 70 n. 1, p. 25-30 How to Cite?
AbstractThis double-blind randomized crossover study compared the analgesic efficacy of pre- and postoperative administration of oral pregabalin 75 mg using a postsurgical dental pain model. Patients requiring third molar surgery in 2 separate stages under local anesthesia were recruited. They were given pregabalin 75 mg either 1 hour before or after their first surgical extraction. They then received the same dose of pregabalin at their second surgical extraction, but those who received it before surgery received it postsurgery, and vice versa. Postoperative analgesic effects were assessed at postoperative hours 2, 4, 8, 12, 24, 48, and 72. Time to first analgesic, analgesic consumption and adverse events were also evaluated. Forty patients were recruited, and 34 completed the study. The area under curves for numerical rating scale pain scores 1 to 24 hours were significantly lower at rest but not during mouth opening for patients receiving postoperative pregabalin (P <.048). Pain relief was similar for the period of 24 to 72 hours. No significant difference was found in time to first analgesic, total analgesic consumption, and side effects between preoperative and postoperative groups. No difference in the incidence of adverse events was noticed in relation to the timing of pregabalin administration. Postoperative administration of oral pregabalin 75 mg appears to offer better analgesic efficacy than preoperative administration after third molar surgery under local anesthesia. © 2012 American Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/141677
ISSN
2015 Impact Factor: 1.631
2015 SCImago Journal Rankings: 0.824
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CWen_HK
dc.contributor.authorChoi, WSen_HK
dc.contributor.authorLeung, YYen_HK
dc.contributor.authorLui, Fen_HK
dc.contributor.authorNg, JKFen_HK
dc.contributor.authorHeiHo, AMen_HK
dc.contributor.authorIrwin, MGen_HK
dc.date.accessioned2011-09-27T02:57:41Z-
dc.date.available2011-09-27T02:57:41Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2012, v. 70 n. 1, p. 25-30en_HK
dc.identifier.issn0278-2391en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141677-
dc.description.abstractThis double-blind randomized crossover study compared the analgesic efficacy of pre- and postoperative administration of oral pregabalin 75 mg using a postsurgical dental pain model. Patients requiring third molar surgery in 2 separate stages under local anesthesia were recruited. They were given pregabalin 75 mg either 1 hour before or after their first surgical extraction. They then received the same dose of pregabalin at their second surgical extraction, but those who received it before surgery received it postsurgery, and vice versa. Postoperative analgesic effects were assessed at postoperative hours 2, 4, 8, 12, 24, 48, and 72. Time to first analgesic, analgesic consumption and adverse events were also evaluated. Forty patients were recruited, and 34 completed the study. The area under curves for numerical rating scale pain scores 1 to 24 hours were significantly lower at rest but not during mouth opening for patients receiving postoperative pregabalin (P <.048). Pain relief was similar for the period of 24 to 72 hours. No significant difference was found in time to first analgesic, total analgesic consumption, and side effects between preoperative and postoperative groups. No difference in the incidence of adverse events was noticed in relation to the timing of pregabalin administration. Postoperative administration of oral pregabalin 75 mg appears to offer better analgesic efficacy than preoperative administration after third molar surgery under local anesthesia. © 2012 American Association of Oral and Maxillofacial Surgeons.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jomsen_HK
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_HK
dc.titleA double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-2391&volume=&spage=&epage=&date=2011&atitle=A+double-blind+randomized+crossover+study+to+evaluate+the+timing+of+pregabalin+for+third+molar+surgery+under+local+anesthesia-
dc.identifier.emailCheung, CW:cheucw@hku.hken_HK
dc.identifier.emailChoi, WS:drwchoi@hku.hken_HK
dc.identifier.emailLeung, YY:mleung04@hku.hken_HK
dc.identifier.emailNg, JKF:jkfng@hkucc.hku.hken_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.authorityCheung, CW=rp00244en_HK
dc.identifier.authorityChoi, WS=rp01521en_HK
dc.identifier.authorityLeung, YY=rp01522en_HK
dc.identifier.authorityNg, JKF=rp00544en_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.joms.2011.03.056en_HK
dc.identifier.pmid21820233-
dc.identifier.scopuseid_2-s2.0-84355161763en_HK
dc.identifier.hkuros193534-
dc.identifier.hkuros228599-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84355161763&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue1en_HK
dc.identifier.spage25en_HK
dc.identifier.epage30en_HK
dc.identifier.eissn1531-5053-
dc.identifier.isiWOS:000299214500025-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, CW=24754835800en_HK
dc.identifier.scopusauthoridChoi, WS=25824732000en_HK
dc.identifier.scopusauthoridLeung, YY=34978641900en_HK
dc.identifier.scopusauthoridLui, F=36863963600en_HK
dc.identifier.scopusauthoridNg, JKF=13608809400en_HK
dc.identifier.scopusauthoridHeiHo, AM=45161371100en_HK
dc.identifier.scopusauthoridIrwin, MG=7202411076en_HK

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