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Article: Delayed post-ischemic conditioning significantly improves the outcome after retinal ischemia

TitleDelayed post-ischemic conditioning significantly improves the outcome after retinal ischemia
Authors
KeywordsIschemia
Post-conditioning
Rat
Retina
Issue Date2011
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexer
Citation
Experimental Eye Research, 2011, v. 92 n. 6, p. 521-527 How to Cite?
AbstractIn previous studies, it was shown that post-conditioning, a transient period of brief ischemia following prolonged severe ischemia in the retina, could provide significant improvement in post-ischemic recovery, attenuation of cell loss, and decreased apoptosis. These studies showed that post-conditioning effectively prevented damage after retinal ischemia when it was instituted early (within 1 h) in the post-ischemic period. While post-ischemic conditioning holds high promise of clinical translation, patients often present late after the onset of retinal ischemia and therefore immediate application of this anti-ischemic maneuver is generally not feasible. In this study, we examined the hypothesis that application of a post-conditioning stimulus at 24 h or greater following the end of prolonged ischemia would decrease the extent of ischemic injury. Ischemia was induced in rat retina in vivo. Recovery after ischemia followed by 5 min of post-conditioning brief ischemia 24 or 48 h after prolonged ischemia was assessed functionally (electroretinography) and histologically at 7 days after ischemia and post-conditioning or sham post-conditioning. We found that the brief ischemic stimulus applied 24, but not 48 h after prolonged ischemia significantly improved functional recovery and decreased histological damage induced by prolonged ischemia. We conclude that within a defined time window, delayed post-ischemic conditioning ameliorated post-ischemic injury in rats. Compared to earlier studies, the present work demonstrates for the first time the novel ability of a significantly delayed ischemic stimulus to provide robust neuroprotection in the retina following ischemia. © 2011 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/141083
ISSN
2015 Impact Factor: 2.998
2015 SCImago Journal Rankings: 1.218
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
National Institutes of Health (Rockville, MD)EY10343
EY10343-16S1
AG029795-02
UL1RR024999
Illinois Society for the Prevention of Blindness (Chicago, IL)
France and Chicago Collaborating in the Sciences (The Chicago-France Center, Chicago, IL)
Dean's Research Advisory Committee of the Division of Biological Sciences of the University of Chicago
American Academy of Neurology, St Paul, MN
Funding Information:

Supported by National Institutes of Health (Rockville, MD) grants EY10343 and EY10343-16S1 (American Recovery and Reinvestment Act) to Dr Roth, AG029795-02 for the Medical Student Summer Research Program at the Pritzker School of Medicine, UL1RR024999 to the University of Chicago Institute for Translational Medicine; the Illinois Society for the Prevention of Blindness (Chicago, IL); France and Chicago Collaborating in the Sciences (The Chicago-France Center, Chicago, IL); and the Dean's Research Advisory Committee of the Division of Biological Sciences of the University of Chicago. Jacqueline N. Poston was the recipient of a Medical Student Research Fellowship Award from the American Academy of Neurology, St Paul, MN. There is no conflict of interest or commercial interest for any of the authors.

References

 

DC FieldValueLanguage
dc.contributor.authorDreixler, JCen_HK
dc.contributor.authorPoston, JNen_HK
dc.contributor.authorShaikh, ARen_HK
dc.contributor.authorAlexander, Men_HK
dc.contributor.authorTupper, KYen_HK
dc.contributor.authorMarcet, MMen_HK
dc.contributor.authorBernaudin, Men_HK
dc.contributor.authorRoth, Sen_HK
dc.date.accessioned2011-09-23T06:25:10Z-
dc.date.available2011-09-23T06:25:10Z-
dc.date.issued2011en_HK
dc.identifier.citationExperimental Eye Research, 2011, v. 92 n. 6, p. 521-527en_HK
dc.identifier.issn0014-4835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141083-
dc.description.abstractIn previous studies, it was shown that post-conditioning, a transient period of brief ischemia following prolonged severe ischemia in the retina, could provide significant improvement in post-ischemic recovery, attenuation of cell loss, and decreased apoptosis. These studies showed that post-conditioning effectively prevented damage after retinal ischemia when it was instituted early (within 1 h) in the post-ischemic period. While post-ischemic conditioning holds high promise of clinical translation, patients often present late after the onset of retinal ischemia and therefore immediate application of this anti-ischemic maneuver is generally not feasible. In this study, we examined the hypothesis that application of a post-conditioning stimulus at 24 h or greater following the end of prolonged ischemia would decrease the extent of ischemic injury. Ischemia was induced in rat retina in vivo. Recovery after ischemia followed by 5 min of post-conditioning brief ischemia 24 or 48 h after prolonged ischemia was assessed functionally (electroretinography) and histologically at 7 days after ischemia and post-conditioning or sham post-conditioning. We found that the brief ischemic stimulus applied 24, but not 48 h after prolonged ischemia significantly improved functional recovery and decreased histological damage induced by prolonged ischemia. We conclude that within a defined time window, delayed post-ischemic conditioning ameliorated post-ischemic injury in rats. Compared to earlier studies, the present work demonstrates for the first time the novel ability of a significantly delayed ischemic stimulus to provide robust neuroprotection in the retina following ischemia. © 2011 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexeren_HK
dc.relation.ispartofExperimental Eye Researchen_HK
dc.subjectIschemiaen_HK
dc.subjectPost-conditioningen_HK
dc.subjectRaten_HK
dc.subjectRetinaen_HK
dc.subject.meshApoptosis - physiology-
dc.subject.meshIschemic Postconditioning-
dc.subject.meshReperfusion Injury - physiopathology - prevention and control-
dc.subject.meshRetinal Diseases - physiopathology - prevention and control-
dc.subject.meshRetinal Vessels - physiology-
dc.titleDelayed post-ischemic conditioning significantly improves the outcome after retinal ischemiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0014-4835&volume=92&issue=6&spage=521&epage=527&date=2011&atitle=Delayed+post-ischemic+conditioning+significantly+improves+the+outcome+after+retinal+ischemia-
dc.identifier.emailMarcet, MM: marcet@hku.hken_HK
dc.identifier.authorityMarcet, MM=rp01363en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.exer.2011.03.015en_HK
dc.identifier.pmid21501608-
dc.identifier.pmcidPMC3833257-
dc.identifier.scopuseid_2-s2.0-79956363661en_HK
dc.identifier.hkuros192920en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956363661&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume92en_HK
dc.identifier.issue6en_HK
dc.identifier.spage521en_HK
dc.identifier.epage527en_HK
dc.identifier.eissn1096-0007-
dc.identifier.isiWOS:000291376200012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridDreixler, JC=6602518830en_HK
dc.identifier.scopusauthoridPoston, JN=48061473100en_HK
dc.identifier.scopusauthoridShaikh, AR=7101736509en_HK
dc.identifier.scopusauthoridAlexander, M=37025529800en_HK
dc.identifier.scopusauthoridTupper, KY=48061583400en_HK
dc.identifier.scopusauthoridMarcet, MM=8891087900en_HK
dc.identifier.scopusauthoridBernaudin, M=6602855984en_HK
dc.identifier.scopusauthoridRoth, S=7402433182en_HK
dc.identifier.citeulike9189158-

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