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Article: An autoimmunized mouse model recapitulates key features in the pathogenesis of Sjugren's syndrome

TitleAn autoimmunized mouse model recapitulates key features in the pathogenesis of Sjugren's syndrome
Authors
KeywordsApoptosis
Aquaporin 5
M3 mucarinic acetylcholine receptor
Mouse model
Sjögren's syndrome
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://intimm.oxfordjournals.org/
Citation
International Immunology, 2011, v. 23 n. 10, p. 613-624 How to Cite?
AbstractThe pathogenesis of Sjö gren's syndrome (SS) is poorly understood. To evaluate an autoimmunization-induced experimental SS model, we firstly observed the phenotype of lymphocyte infiltration in the enlarged submandibular gland (SG). Furthermore, significant activation of caspase-3 and a high ratio of Bax-to-Bcl-2 were detected, indicating the inflammatory apoptosis associated with developmental foci. Meanwhile, the dysregulated cytokines, such as tumor necrosis factor a, IL-1b and IL-6 mRNA expression, were found to be over-expressed. A progressive decrease of aquaporin 5 and its subcellular translocation from apical to basal membrane in SG was found to be associated with the abnormally expressed M3 muscarinic acetylcholine receptor. This pattern was found to be similar to that seen in human SS and possibly contributed to the saliva secretion deficiency. Thus, this autoimmunization-induced model recapitulates the key features of human SS and may have potential for studying the pathogenesis of human SS. © The Japanese Society for Immunology. 2011. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/141040
ISSN
2015 Impact Factor: 3.031
2015 SCImago Journal Rankings: 1.613
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong201011159206
201007160006
Funding Information:

University of Hong Kong Project No. (201011159206 and 201007160006)

References

 

DC FieldValueLanguage
dc.contributor.authorLin, Xen_HK
dc.contributor.authorSong, Jxen_HK
dc.contributor.authorShaw, PCen_HK
dc.contributor.authorNg, TBen_HK
dc.contributor.authorSze, SCen_HK
dc.contributor.authorTong, Yen_HK
dc.contributor.authorLee, KFen_HK
dc.contributor.authorZhang, KYen_HK
dc.date.accessioned2011-09-23T06:24:12Z-
dc.date.available2011-09-23T06:24:12Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Immunology, 2011, v. 23 n. 10, p. 613-624en_HK
dc.identifier.issn0953-8178en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141040-
dc.description.abstractThe pathogenesis of Sjö gren's syndrome (SS) is poorly understood. To evaluate an autoimmunization-induced experimental SS model, we firstly observed the phenotype of lymphocyte infiltration in the enlarged submandibular gland (SG). Furthermore, significant activation of caspase-3 and a high ratio of Bax-to-Bcl-2 were detected, indicating the inflammatory apoptosis associated with developmental foci. Meanwhile, the dysregulated cytokines, such as tumor necrosis factor a, IL-1b and IL-6 mRNA expression, were found to be over-expressed. A progressive decrease of aquaporin 5 and its subcellular translocation from apical to basal membrane in SG was found to be associated with the abnormally expressed M3 muscarinic acetylcholine receptor. This pattern was found to be similar to that seen in human SS and possibly contributed to the saliva secretion deficiency. Thus, this autoimmunization-induced model recapitulates the key features of human SS and may have potential for studying the pathogenesis of human SS. © The Japanese Society for Immunology. 2011. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://intimm.oxfordjournals.org/en_HK
dc.relation.ispartofInternational Immunologyen_HK
dc.subjectApoptosisen_HK
dc.subjectAquaporin 5en_HK
dc.subjectM3 mucarinic acetylcholine receptoren_HK
dc.subjectMouse modelen_HK
dc.subjectSjögren's syndromeen_HK
dc.titleAn autoimmunized mouse model recapitulates key features in the pathogenesis of Sjugren's syndromeen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0953-8178&volume=&spage=&epage=&date=2011&atitle=An+autoimmunized+mouse+model+recapitulates+key+features+in+the+pathogenesis+of+Sjogren%27s+syndromeen_US
dc.identifier.emailSze, SC: stephens@hku.hken_HK
dc.identifier.emailTong, Y: tongyao@hku.hken_HK
dc.identifier.emailLee, KF: ckflee@hku.hken_HK
dc.identifier.emailZhang, KY: ybzhang@hku.hken_HK
dc.identifier.authoritySze, SC=rp00514en_HK
dc.identifier.authorityTong, Y=rp00509en_HK
dc.identifier.authorityLee, KF=rp00458en_HK
dc.identifier.authorityZhang, KY=rp01410en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/intimm/dxr066en_HK
dc.identifier.pmid21846814-
dc.identifier.scopuseid_2-s2.0-80053549919en_HK
dc.identifier.hkuros192446en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80053549919&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue10en_HK
dc.identifier.spage613en_HK
dc.identifier.epage624en_HK
dc.identifier.isiWOS:000295507800003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLin, X=36101204400en_HK
dc.identifier.scopusauthoridSong, Jx=24339343800en_HK
dc.identifier.scopusauthoridShaw, PC=35599523600en_HK
dc.identifier.scopusauthoridNg, TB=35311803300en_HK
dc.identifier.scopusauthoridSze, SC=23482617000en_HK
dc.identifier.scopusauthoridTong, Y=9045384000en_HK
dc.identifier.scopusauthoridLee, KF=26643097500en_HK
dc.identifier.scopusauthoridZhang, KY=23483121900en_HK

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