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Article: Neural coding of movement direction in the healthy human brain
Title | Neural coding of movement direction in the healthy human brain | ||||||||||||||||
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Authors | |||||||||||||||||
Issue Date | 2010 | ||||||||||||||||
Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | ||||||||||||||||
Citation | Plos One, 2010, v. 5 n. 10 How to Cite? | ||||||||||||||||
Abstract | Neurophysiological studies in monkeys show that activity of neurons in primary cortex (M1), pre-motor cortex (PMC), and cerebellum varies systematically with the direction of reaching movements. These neurons exhibit preferred direction tuning, where the level of neural activity is highest when movements are made in the preferred direction (PD), and gets progressively lower as movements are made at increasing degrees of offset from the PD. Using a functional magnetic resonance imaging adaptation (fMRI-A) paradigm, we show that PD coding does exist in regions of the human motor system that are homologous to those observed in non-human primates. Consistent with predictions of the PD model, we show adaptation (i.e., a lower level) of the blood oxygen level dependent (BOLD) time-course signal in M1, PMC, SMA, and cerebellum when consecutive wrist movements were made in the same direction (0° offset) relative to movements offset by 90° or 180°. The BOLD signal in dorsolateral prefrontal cortex adapted equally in all movement offset conditions, mitigating against the possibility that the present results are the consequence of differential task complexity or attention to action in each movement offset condition. Copyright: © 2010 Cowper-Smith et al. | ||||||||||||||||
Persistent Identifier | http://hdl.handle.net/10722/141022 | ||||||||||||||||
ISSN | 2021 Impact Factor: 3.752 2020 SCImago Journal Rankings: 0.990 | ||||||||||||||||
PubMed Central ID | |||||||||||||||||
ISI Accession Number ID |
Funding Information: This research was funded by the Nova Scotia Health Research Foundation and the Dalhousie Medical Research Foundation. CCS was supported by studentships from the Canadian Institutes of Health Research/Institutes de recherche en sante du Canada (CIHR/IRCS) and the Nova Scotia Health Research Foundation (NSHRF). This research was previously published as part of CCS' MSc thesis. EL was supported by the Sir Edward Youde Memorial Overseas Fellowship, and GE was supported by a Dalhousie Faculty of Medicine Clinical Research Scholar Award. DW was supported by a CIHR New Investigator Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | ||||||||||||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | CowperSmith, CD | en_HK |
dc.contributor.author | Lau, EYY | en_HK |
dc.contributor.author | Helmick, CA | en_HK |
dc.contributor.author | Eskes, GA | en_HK |
dc.contributor.author | Westwood, DA | en_HK |
dc.date.accessioned | 2011-09-23T06:23:34Z | - |
dc.date.available | 2011-09-23T06:23:34Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Plos One, 2010, v. 5 n. 10 | en_HK |
dc.identifier.issn | 1932-6203 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/141022 | - |
dc.description.abstract | Neurophysiological studies in monkeys show that activity of neurons in primary cortex (M1), pre-motor cortex (PMC), and cerebellum varies systematically with the direction of reaching movements. These neurons exhibit preferred direction tuning, where the level of neural activity is highest when movements are made in the preferred direction (PD), and gets progressively lower as movements are made at increasing degrees of offset from the PD. Using a functional magnetic resonance imaging adaptation (fMRI-A) paradigm, we show that PD coding does exist in regions of the human motor system that are homologous to those observed in non-human primates. Consistent with predictions of the PD model, we show adaptation (i.e., a lower level) of the blood oxygen level dependent (BOLD) time-course signal in M1, PMC, SMA, and cerebellum when consecutive wrist movements were made in the same direction (0° offset) relative to movements offset by 90° or 180°. The BOLD signal in dorsolateral prefrontal cortex adapted equally in all movement offset conditions, mitigating against the possibility that the present results are the consequence of differential task complexity or attention to action in each movement offset condition. Copyright: © 2010 Cowper-Smith et al. | en_HK |
dc.language | eng | en_US |
dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | en_HK |
dc.relation.ispartof | PLoS ONE | en_HK |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject.mesh | Brain - physiology | - |
dc.subject.mesh | Female | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Magnetic Resonance Imaging | - |
dc.subject.mesh | Male | - |
dc.title | Neural coding of movement direction in the healthy human brain | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Lau, EYY:eyylau@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lau, EYY=rp00634 | en_HK |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1371/journal.pone.0013330 | en_HK |
dc.identifier.pmid | 20967197 | - |
dc.identifier.pmcid | PMC2954155 | - |
dc.identifier.scopus | eid_2-s2.0-78149440479 | en_HK |
dc.identifier.hkuros | 193169 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-78149440479&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 5 | en_HK |
dc.identifier.issue | 10 | en_HK |
dc.identifier.spage | e13330 | en_US |
dc.identifier.epage | e13330 | en_US |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.isi | WOS:000282869800028 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | CowperSmith, CD=24479665700 | en_HK |
dc.identifier.scopusauthorid | Lau, EYY=36448882600 | en_HK |
dc.identifier.scopusauthorid | Helmick, CA=36876255400 | en_HK |
dc.identifier.scopusauthorid | Eskes, GA=6701737958 | en_HK |
dc.identifier.scopusauthorid | Westwood, DA=7004675361 | en_HK |
dc.identifier.issnl | 1932-6203 | - |