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Article: Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children

TitleAssociation of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children
Authors
Issue Date2011
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.behavioralandbrainfunctions.com/home
Citation
Behavioral And Brain Functions, 2011, v. 7 How to Cite?
AbstractBackground: Dyslexia is a learning disability that is characterized by difficulties in the acquisition of reading and spelling skills independent of intelligence, motivation or schooling. Studies of western populations have suggested that DYX1C1 is a candidate gene for dyslexia. In view of the different languages used in Caucasian and Chinese populations, it is therefore worthwhile to investigate whether there is an association of DYX1C1 in Chinese children with dyslexia.Method and Results: Eight single nucleotide polymorphisms (SNPs) were genotyped from three hundred and ninety three individuals from 131 Chinese families with two which have been reported in the literature and six tag SNPs at DYX1C1. Analysis for allelic and haplotypic associations was performed with the UNPHASED program and multiple testing was corrected using false discovery rates. We replicated the previously reported association of rs3743205 in Chinese children with dyslexia (p corrected = 0.0072). This SNP was also associated with rapid naming, phonological memory and orthographic skills in quantitative trait analysis.Conclusion: Our findings suggest that DYX1C1 is associated with dyslexia in people of Chinese ethnicity in Hong Kong. © 2011 Lim et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/141012
ISSN
2015 Impact Factor: 1.72
2015 SCImago Journal Rankings: 0.989
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Croucher Foundation
Funding Information:

This work was partly supported by donations from the Croucher Foundation awarded to MW. We thank Amabel Wong and Helen Chan for their technical assistance with genotyping experiments. We also thank all the families and volunteers who participated, the Hong Kong Association for Specific Learning Disabilities and the Child Assessment Service (Department of Heath) for their assistance in subject recruitment.

References

 

DC FieldValueLanguage
dc.contributor.authorLim, CKPen_HK
dc.contributor.authorHo, CSHen_HK
dc.contributor.authorChou, CHNen_HK
dc.contributor.authorWaye, MMYen_HK
dc.date.accessioned2011-09-23T06:23:29Z-
dc.date.available2011-09-23T06:23:29Z-
dc.date.issued2011en_HK
dc.identifier.citationBehavioral And Brain Functions, 2011, v. 7en_HK
dc.identifier.issn1744-9081en_HK
dc.identifier.urihttp://hdl.handle.net/10722/141012-
dc.description.abstractBackground: Dyslexia is a learning disability that is characterized by difficulties in the acquisition of reading and spelling skills independent of intelligence, motivation or schooling. Studies of western populations have suggested that DYX1C1 is a candidate gene for dyslexia. In view of the different languages used in Caucasian and Chinese populations, it is therefore worthwhile to investigate whether there is an association of DYX1C1 in Chinese children with dyslexia.Method and Results: Eight single nucleotide polymorphisms (SNPs) were genotyped from three hundred and ninety three individuals from 131 Chinese families with two which have been reported in the literature and six tag SNPs at DYX1C1. Analysis for allelic and haplotypic associations was performed with the UNPHASED program and multiple testing was corrected using false discovery rates. We replicated the previously reported association of rs3743205 in Chinese children with dyslexia (p corrected = 0.0072). This SNP was also associated with rapid naming, phonological memory and orthographic skills in quantitative trait analysis.Conclusion: Our findings suggest that DYX1C1 is associated with dyslexia in people of Chinese ethnicity in Hong Kong. © 2011 Lim et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.behavioralandbrainfunctions.com/homeen_HK
dc.relation.ispartofBehavioral and Brain Functionsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsBehavioral and Brain Functions. Copyright © BioMed Central Ltd.-
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshDyslexia - genetics-
dc.subject.meshGenetic Association Studies - methods-
dc.subject.meshGenetic Predisposition to Disease - genetics-
dc.subject.meshNerve Tissue Proteins - genetics - physiology-
dc.titleAssociation of the rs3743205 variant of DYX1C1 with dyslexia in Chinese childrenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1744-9081&volume=7, article no. 16&spage=&epage=&date=2011&atitle=Association+of+the+rs3743205+variant+of+DYX1C1+with+dyslexia+in+Chinese+children-
dc.identifier.emailHo, CSH:shhoc@hkucc.hku.hken_HK
dc.identifier.authorityHo, CSH=rp00631en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1744-9081-7-16en_HK
dc.identifier.pmid21599957-
dc.identifier.pmcidPMC3123182-
dc.identifier.scopuseid_2-s2.0-79956222419en_HK
dc.identifier.hkuros192887en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956222419&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.isiWOS:000292021800001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLim, CKP=41561830300en_HK
dc.identifier.scopusauthoridHo, CSH=35095289900en_HK
dc.identifier.scopusauthoridChou, CHN=41561050000en_HK
dc.identifier.scopusauthoridWaye, MMY=7006687733en_HK
dc.identifier.citeulike9326777-

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