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Conference Paper: The antioxidative effect of propofol on angiotesin II-induced apoptosis in neonatal rat cardiomyocytes

TitleThe antioxidative effect of propofol on angiotesin II-induced apoptosis in neonatal rat cardiomyocytes
Authors
Issue Date2010
Citation
The 15th World Congress on Heart Disease, International Academy of Cardiology Annual Scientific Sessions 2010, Vancouver, B.C., Canada, 24-27 July 2010. How to Cite?
AbstractPropofol (2,6-diisopropylphenol), an intravenous sedative Vhypnotic agent popular for sedation, has been found to be effective in protecting against pathological states characterized by an increase in basal rate of reactive oxygen species (ROS) production in hearts, but the cardioprotective mechanism is not well established. Angiotensin-II (Ang-II), an important neurohormonal factor during heart failure, can induce cardiomyocyte apoptosis which has an important role in the transition from compensatory cardiac remodeling to heart failure. In the present study, we evaluated the effects of propofol on Ang-II-mediated cardiomyocyte apoptosis. Cultured cardiomyocytes from neonatal rats were stimulated with Ang-II. Apoptosis was evaluated by measuring caspase 3 activity and by TdT-mediated dUTP nick-end labeling (TUNEL) method. It was found that incubation with Ang-II (0.1 micromolar) for 48 h increased cardiomyocyte apoptosis. Administration of propofol ...
DescriptionTheme: New Horizons on Cardiovascular Diseases
Poster
Persistent Identifierhttp://hdl.handle.net/10722/140858

 

DC FieldValueLanguage
dc.contributor.authorWong, Ken_US
dc.contributor.authorLeung, YMen_US
dc.contributor.authorLu, DYen_US
dc.contributor.authorCheng, THen_US
dc.date.accessioned2011-09-23T06:20:20Z-
dc.date.available2011-09-23T06:20:20Z-
dc.date.issued2010en_US
dc.identifier.citationThe 15th World Congress on Heart Disease, International Academy of Cardiology Annual Scientific Sessions 2010, Vancouver, B.C., Canada, 24-27 July 2010.en_US
dc.identifier.urihttp://hdl.handle.net/10722/140858-
dc.descriptionTheme: New Horizons on Cardiovascular Diseases-
dc.descriptionPoster-
dc.description.abstractPropofol (2,6-diisopropylphenol), an intravenous sedative Vhypnotic agent popular for sedation, has been found to be effective in protecting against pathological states characterized by an increase in basal rate of reactive oxygen species (ROS) production in hearts, but the cardioprotective mechanism is not well established. Angiotensin-II (Ang-II), an important neurohormonal factor during heart failure, can induce cardiomyocyte apoptosis which has an important role in the transition from compensatory cardiac remodeling to heart failure. In the present study, we evaluated the effects of propofol on Ang-II-mediated cardiomyocyte apoptosis. Cultured cardiomyocytes from neonatal rats were stimulated with Ang-II. Apoptosis was evaluated by measuring caspase 3 activity and by TdT-mediated dUTP nick-end labeling (TUNEL) method. It was found that incubation with Ang-II (0.1 micromolar) for 48 h increased cardiomyocyte apoptosis. Administration of propofol ...-
dc.languageengen_US
dc.relation.ispartof15th World Congress on Heart Disease, International Academy of Cardiology Annual Scientific Sessions 2010en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleThe antioxidative effect of propofol on angiotesin II-induced apoptosis in neonatal rat cardiomyocytesen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, K: wongeric@hku.hken_US
dc.identifier.emailLu, DY: dahyuu@mail.cmu.edu.tw-
dc.description.naturepostprint-
dc.identifier.hkuros193486en_US

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