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Conference Paper: Melatonin attenuates intermittent hypoxia induced oxidative stress and tissue inflammation in rat adrenal medulla

TitleMelatonin attenuates intermittent hypoxia induced oxidative stress and tissue inflammation in rat adrenal medulla
Authors
KeywordsCardiovascular disease
Issue Date2010
PublisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
Citation
The 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, China, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 76, abstract no. P20 How to Cite?
AbstractHeme oxygenase (HO) catalyzes heme into carbon monoxide, free iron and biliverdin. A large amount of data demonstrates that HO-1, an inducible isoform of HO, can exert vaso-protective effects. However, such vascular benefit in diabetic vasculopathy remains largely unknown. The present study investigates the impact of HO-1 induction on endothelial dysfunction in type 2 diabetic db/db mice. Diabetic db/db and non-diabetic db/m+ mice were treated with hemin (a potent inducer of HO-1) for two weeks or vehicle. The aortae were isolated and suspended in myograph for force measurement and levels of marker proteins were determined by the Western blotting method. Two-week hemin administration restored the impaired endotheliumdependent relaxation to acetylcholine in db/db mice, which could be reversed by co-treatment with HO-1 inhibitor SnMP. The effect of hemin could also be …
DescriptionThis journal issue is proceedings of ICSM 2010
Poster Session
Persistent Identifierhttp://hdl.handle.net/10722/140561
ISSN
2015 SCImago Journal Rankings: 0.102

 

DC FieldValueLanguage
dc.contributor.authorLiu, Yen_US
dc.contributor.authorFung, MLen_US
dc.date.accessioned2011-09-23T06:14:23Z-
dc.date.available2011-09-23T06:14:23Z-
dc.date.issued2010en_US
dc.identifier.citationThe 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, China, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 76, abstract no. P20en_US
dc.identifier.issn1027-7811-
dc.identifier.urihttp://hdl.handle.net/10722/140561-
dc.descriptionThis journal issue is proceedings of ICSM 2010-
dc.descriptionPoster Session-
dc.description.abstractHeme oxygenase (HO) catalyzes heme into carbon monoxide, free iron and biliverdin. A large amount of data demonstrates that HO-1, an inducible isoform of HO, can exert vaso-protective effects. However, such vascular benefit in diabetic vasculopathy remains largely unknown. The present study investigates the impact of HO-1 induction on endothelial dysfunction in type 2 diabetic db/db mice. Diabetic db/db and non-diabetic db/m+ mice were treated with hemin (a potent inducer of HO-1) for two weeks or vehicle. The aortae were isolated and suspended in myograph for force measurement and levels of marker proteins were determined by the Western blotting method. Two-week hemin administration restored the impaired endotheliumdependent relaxation to acetylcholine in db/db mice, which could be reversed by co-treatment with HO-1 inhibitor SnMP. The effect of hemin could also be …-
dc.languageengen_US
dc.publisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3-
dc.relation.ispartofJournal of the Hong Kong College of Cardiologyen_US
dc.subjectCardiovascular disease-
dc.titleMelatonin attenuates intermittent hypoxia induced oxidative stress and tissue inflammation in rat adrenal medullaen_US
dc.typeConference_Paperen_US
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1027-7811&volume=18&issue=2&spage=20&epage=&date=2010&atitle=Melatonin+attenuates+intermittent+hypoxia+induced+oxidative+stress+and+tissue+inflammation+in+rat+adrenal+medulla-
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros195783en_US
dc.identifier.volume18en_US
dc.identifier.issue2en_US
dc.identifier.spage76en_US
dc.identifier.epage76en_US
dc.publisher.placeHong Kong-
dc.description.otherThe 14th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, China, 18 December 2010. In Journal of the Hong Kong College of Cardiology, 2010, v. 18 n. 2, p. 76, abstract no. P20-

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