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Conference Paper: Spindle-like oscillations in the auditory thalamus and cortex

TitleSpindle-like oscillations in the auditory thalamus and cortex
Authors
KeywordsSpindle oscillation
GABA receptor antagonist
Medial geniculate body
Issue Date2010
PublisherSociety for Neuroscience.
Citation
The 40th Annual Meeting of the Society for Neuroscience (SfN 2010), San Diego, California, USA, 13-17 November 2010 How to Cite?
AbstractIn the present study, we investigated the spindle oscillation in the thalamic reticular nucleus (TRN), medial geniculate body (MGB) and auditory cortex (AC). Neuronal activities in above regions were simultaneously recorded with extracellular and intracellular electrodes. We have found that thalamocortical neurons exhibit membrane oscillations that have spindle frequencies consist of excitatory postsynaptic potentials (EPSP). Acoustic stimuli could trigger membrane oscillation in EPSPs with spikes. TRN lesioning or injection of a combination of GABAA and GABAB antagonists into the MGB resulted in slowed oscillation in the MGB. Injection of GABAA antagonist into the MGB decreased oscillation frequency in the MGB and AC. In preparations in which AC was removed and the TRN was deafferented with glutamate receptor antagonists, oscillation frequency in the MGB was fastened by rhythmic electrical stimulation of the TRN. Our results therefore support the model that cortical spindles in the auditory system are originated in the MGB and are modulated by inhibitory inputs from the TRN. Fast inhibition through GABAA receptors facilitates the internal frequency of the oscillations while slow inhibition through GABAB receptors limits the occurrence of the oscillations. (Supported by CERG PolyU 5610/08M) Keywords: Spindle oscillation; Thalamic reticular nucleus; Medial geniculate body; Auditory cortex; excitatory postsynaptic potential (EPSP); GABA receptor antagonist
DescriptionPoster session: 553.Fast and Slow Oscillations
Program#553.12 & Poster#I14
Fulltext of the abstract in: http://www.abstractsonline.com/plan/ViewAbstract.aspx?cKey=692680b3-224f-4eb7-81b7-6a8049c7c3a1&mID=2554&mKey=%7bE5D5C83F-CE2D-4D71-9DD6-FC7231E090FB%7d&sKey=04c8499f-e115-4654-bcd0-39948f05c940
Persistent Identifierhttp://hdl.handle.net/10722/140521

 

DC FieldValueLanguage
dc.contributor.authorLiu, CHen_US
dc.contributor.authorGuo, Yen_US
dc.contributor.authorGao, LXen_US
dc.contributor.authorMeng, XKen_US
dc.contributor.authorYu, YQen_US
dc.contributor.authorChan, YSen_US
dc.contributor.authorHe, Jen_US
dc.date.accessioned2011-09-23T06:13:54Z-
dc.date.available2011-09-23T06:13:54Z-
dc.date.issued2010en_US
dc.identifier.citationThe 40th Annual Meeting of the Society for Neuroscience (SfN 2010), San Diego, California, USA, 13-17 November 2010en_US
dc.identifier.urihttp://hdl.handle.net/10722/140521-
dc.descriptionPoster session: 553.Fast and Slow Oscillations-
dc.descriptionProgram#553.12 & Poster#I14-
dc.descriptionFulltext of the abstract in: http://www.abstractsonline.com/plan/ViewAbstract.aspx?cKey=692680b3-224f-4eb7-81b7-6a8049c7c3a1&mID=2554&mKey=%7bE5D5C83F-CE2D-4D71-9DD6-FC7231E090FB%7d&sKey=04c8499f-e115-4654-bcd0-39948f05c940-
dc.description.abstractIn the present study, we investigated the spindle oscillation in the thalamic reticular nucleus (TRN), medial geniculate body (MGB) and auditory cortex (AC). Neuronal activities in above regions were simultaneously recorded with extracellular and intracellular electrodes. We have found that thalamocortical neurons exhibit membrane oscillations that have spindle frequencies consist of excitatory postsynaptic potentials (EPSP). Acoustic stimuli could trigger membrane oscillation in EPSPs with spikes. TRN lesioning or injection of a combination of GABAA and GABAB antagonists into the MGB resulted in slowed oscillation in the MGB. Injection of GABAA antagonist into the MGB decreased oscillation frequency in the MGB and AC. In preparations in which AC was removed and the TRN was deafferented with glutamate receptor antagonists, oscillation frequency in the MGB was fastened by rhythmic electrical stimulation of the TRN. Our results therefore support the model that cortical spindles in the auditory system are originated in the MGB and are modulated by inhibitory inputs from the TRN. Fast inhibition through GABAA receptors facilitates the internal frequency of the oscillations while slow inhibition through GABAB receptors limits the occurrence of the oscillations. (Supported by CERG PolyU 5610/08M) Keywords: Spindle oscillation; Thalamic reticular nucleus; Medial geniculate body; Auditory cortex; excitatory postsynaptic potential (EPSP); GABA receptor antagonist-
dc.languageengen_US
dc.publisherSociety for Neuroscience.-
dc.relation.ispartofNeuroscience 2010-
dc.rightsNeuroscience 2010. Copyright © Society for Neuroscience.-
dc.subjectSpindle oscillation-
dc.subjectGABA receptor antagonist-
dc.subjectMedial geniculate body-
dc.titleSpindle-like oscillations in the auditory thalamus and cortexen_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, YS: yschan@hku.hken_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.identifier.hkuros195365en_US
dc.publisher.placeUnited States-

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