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Conference Paper: Human cardiac Kv4.3 channels are regulated by EGFR kinase and SRC-family kinases

TitleHuman cardiac Kv4.3 channels are regulated by EGFR kinase and SRC-family kinases
Authors
Issue Date2010
Citation
The International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions 2010, Vancouver, BC, 24-27 July 2010. How to Cite?
AbstractThe transient outward potassium current Ito (encoded by Kv4.3) plays an important role in the phase 1 rapid repolarization of cardiac action potentials in the heart. It further determines the duration of repolarization and the propensity to cardiac arrhythmias. Modulation of Ito by intracellular signal transduction is not understood. The present study was designed to determine whether hKv4.3 channel (alpha-subunit of human cardiac Ito) is regulated by protein tyrosine kinases (PTKs) in HEK 293 cells stably expressing human Kv4.3 gene using a whole-cell patch clamp technique, immunoprecipitation and western blot. It was found that hum...
Persistent Identifierhttp://hdl.handle.net/10722/140447

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yen_US
dc.contributor.authorLau, CPen_US
dc.contributor.authorLi, GRen_US
dc.date.accessioned2011-09-23T06:11:57Z-
dc.date.available2011-09-23T06:11:57Z-
dc.date.issued2010en_US
dc.identifier.citationThe International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions 2010, Vancouver, BC, 24-27 July 2010.en_US
dc.identifier.urihttp://hdl.handle.net/10722/140447-
dc.description.abstractThe transient outward potassium current Ito (encoded by Kv4.3) plays an important role in the phase 1 rapid repolarization of cardiac action potentials in the heart. It further determines the duration of repolarization and the propensity to cardiac arrhythmias. Modulation of Ito by intracellular signal transduction is not understood. The present study was designed to determine whether hKv4.3 channel (alpha-subunit of human cardiac Ito) is regulated by protein tyrosine kinases (PTKs) in HEK 293 cells stably expressing human Kv4.3 gene using a whole-cell patch clamp technique, immunoprecipitation and western blot. It was found that hum...-
dc.languageengen_US
dc.relation.ispartofInternational Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions 2010en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleHuman cardiac Kv4.3 channels are regulated by EGFR kinase and SRC-family kinasesen_US
dc.typeConference_Paperen_US
dc.identifier.emailZhang, Y: yanhuiz@hku.hken_US
dc.identifier.emailLau, CP: cplau@hku.hken_US
dc.identifier.emailLi, GR: grli@hkucc.hku.hk-
dc.identifier.authorityLi, GR=rp00476en_US
dc.description.naturepostprint-
dc.identifier.hkuros195065en_US
dc.customcontrol.immutablesml 130409-

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