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Conference Paper: Human cardiac Kv4.3 channels are regulated by EGFR kinase and SRC-family kinases
| Title | Human cardiac Kv4.3 channels are regulated by EGFR kinase and SRC-family kinases |
|---|---|
| Authors | |
| Issue Date | 2010 |
| Citation | The International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions 2010, Vancouver, BC, 24-27 July 2010. How to Cite? |
| Abstract | The transient outward potassium current Ito (encoded by Kv4.3) plays an important role in the phase 1 rapid repolarization of cardiac action potentials in the heart. It further determines the duration of repolarization and the propensity to cardiac arrhythmias. Modulation of Ito by intracellular signal transduction is not understood. The present study was designed to determine whether hKv4.3 channel (alpha-subunit of human cardiac Ito) is regulated by protein tyrosine kinases (PTKs) in HEK 293 cells stably expressing human Kv4.3 gene using a whole-cell patch clamp technique, immunoprecipitation and western blot. It was found that hum... |
| Persistent Identifier | http://hdl.handle.net/10722/140447 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zhang, Y | en_US |
| dc.contributor.author | Lau, CP | en_US |
| dc.contributor.author | Li, GR | en_US |
| dc.date.accessioned | 2011-09-23T06:11:57Z | - |
| dc.date.available | 2011-09-23T06:11:57Z | - |
| dc.date.issued | 2010 | en_US |
| dc.identifier.citation | The International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions 2010, Vancouver, BC, 24-27 July 2010. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/140447 | - |
| dc.description.abstract | The transient outward potassium current Ito (encoded by Kv4.3) plays an important role in the phase 1 rapid repolarization of cardiac action potentials in the heart. It further determines the duration of repolarization and the propensity to cardiac arrhythmias. Modulation of Ito by intracellular signal transduction is not understood. The present study was designed to determine whether hKv4.3 channel (alpha-subunit of human cardiac Ito) is regulated by protein tyrosine kinases (PTKs) in HEK 293 cells stably expressing human Kv4.3 gene using a whole-cell patch clamp technique, immunoprecipitation and western blot. It was found that hum... | - |
| dc.language | eng | en_US |
| dc.relation.ispartof | International Academy of Cardiology 15th World Congress on Heart Disease Annual Scientific Sessions 2010 | en_US |
| dc.title | Human cardiac Kv4.3 channels are regulated by EGFR kinase and SRC-family kinases | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Zhang, Y: yanhuiz@hku.hk | en_US |
| dc.identifier.email | Lau, CP: cplau@hku.hk | en_US |
| dc.identifier.email | Li, GR: grli@hkucc.hku.hk | - |
| dc.identifier.authority | Li, GR=rp00476 | en_US |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 195065 | en_US |
| dc.customcontrol.immutable | sml 130409 | - |