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Conference Paper: Fabrication of biodegradable poly(lactic acid) particles in flow focusing glass capillary devices

TitleFabrication of biodegradable poly(lactic acid) particles in flow focusing glass capillary devices
Authors
Issue Date2011
PublisherThe Symposium.
Citation
UK Colloids 2011: An International Colloid and Surface Science Symposium, London, U.K., 4-6 July 2011. How to Cite?
AbstractPoly(dl-lactic acid) (PLA) particles with a diameter in the range from 12 to 100 µm were fabricated in flow focusing glass capillary devices shown in Figure 1. The disperse phase was 5% (w/w) PLA in dichloromethane (DCM) containing small amount of nile red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in milli-Q water. The two immiscible liquids were introduced from the two ends of the same square capillary in opposite directions and both liquids were collected and exit through the inner circular capillary. The disperse phase was hydrodynamically flow focused by the continuous phase in the tapered section of the circular capillary, which caused the disperse phase to break into drops inside the collection tube. PLA particles were formed by DCM evaporation at room temperature. In order to prevent wetting of the collection tube with the disperse phase, the hydrophilicity of the glass surface was enhanced by 2-[methoxy(polyethyleneoxy)propyl]trimethoxysilane. Experimentally, we show that the droplet size is influenced by the operating conditions and orifice size, as shown in Fig. 1. The drop formation occurs near the orifice in the dripping regime (Fig. 1a-b) and farther downstream in the jetting regime (Fig. 1c). The drops formed in the jetting regime are significantly bigger than those formed in the dripping regime and have a broader size distribution.
DescriptionPlenary 1 - Manufacture of Colloidal Systems: M9
Persistent Identifierhttp://hdl.handle.net/10722/140315

 

DC FieldValueLanguage
dc.contributor.authorVladisavljevic, GTen_US
dc.contributor.authorDuncanson, WJen_US
dc.contributor.authorShum, HCen_US
dc.contributor.authorWeitz, DAen_US
dc.date.accessioned2011-09-23T06:10:20Z-
dc.date.available2011-09-23T06:10:20Z-
dc.date.issued2011en_US
dc.identifier.citationUK Colloids 2011: An International Colloid and Surface Science Symposium, London, U.K., 4-6 July 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/140315-
dc.descriptionPlenary 1 - Manufacture of Colloidal Systems: M9-
dc.description.abstractPoly(dl-lactic acid) (PLA) particles with a diameter in the range from 12 to 100 µm were fabricated in flow focusing glass capillary devices shown in Figure 1. The disperse phase was 5% (w/w) PLA in dichloromethane (DCM) containing small amount of nile red and the continuous phase was 5% (w/w) poly(vinyl alcohol) in milli-Q water. The two immiscible liquids were introduced from the two ends of the same square capillary in opposite directions and both liquids were collected and exit through the inner circular capillary. The disperse phase was hydrodynamically flow focused by the continuous phase in the tapered section of the circular capillary, which caused the disperse phase to break into drops inside the collection tube. PLA particles were formed by DCM evaporation at room temperature. In order to prevent wetting of the collection tube with the disperse phase, the hydrophilicity of the glass surface was enhanced by 2-[methoxy(polyethyleneoxy)propyl]trimethoxysilane. Experimentally, we show that the droplet size is influenced by the operating conditions and orifice size, as shown in Fig. 1. The drop formation occurs near the orifice in the dripping regime (Fig. 1a-b) and farther downstream in the jetting regime (Fig. 1c). The drops formed in the jetting regime are significantly bigger than those formed in the dripping regime and have a broader size distribution.-
dc.languageengen_US
dc.publisherThe Symposium.-
dc.relation.ispartofUK Colloids 2011en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleFabrication of biodegradable poly(lactic acid) particles in flow focusing glass capillary devicesen_US
dc.typeConference_Paperen_US
dc.identifier.emailVladisavljevic, GT: G.Vladisavljevic@lboro.ac.uken_US
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.authorityShum, HC=rp01439en_US
dc.description.naturepostprint-
dc.identifier.hkuros193740en_US
dc.publisher.placeUnited Kingdom-
dc.description.otherUK Colloids 2011: An International Colloid and Surface Science Symposium, London, U.K., 4-6 July 2011.-

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