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Conference Paper: Investigation of intratumoral heterogeneity in nasopharyngeal carcinoma: a distinct role of PET-CT from MRI

TitleInvestigation of intratumoral heterogeneity in nasopharyngeal carcinoma: a distinct role of PET-CT from MRI
Authors
Issue Date2010
Citation
The 2010 World Molecular Imaging Congress (WMIC 2010), Kyoto, Japan, 8-11 September 2010. How to Cite?
AbstractTumors are heterogeneous due to cellular proliferation, necrosis, noncellular accumulations and physiologic characteristics, etc. It has been reported that heterogeneity is related to outcome, and studying its evolution may help to optimize treatment planning. We aimed to study the role of tumor heterogeneity reflected by PET-CT in the diagnosis of Nasopharyngeal Carcinoma (NPC), a leading cancer type in South China, and the correlation with MRI findings. It was hypothesized that tumor heterogeneity reflected by PET-CT correlated with both NPC diagnosis (SUVmax, tumor volume, stage, etc) and heterogeneity reflected by MRI scanning. A total of 26 newly-diagnosed NPC patients who had received both PET-CT and MRI examinations (interval between PET-CT and MRI scans not longer than two weeks) with the tumor size bigger than 1.5cm in any direction were studied. Intratumoral heterogeneity was calculated by taking the derivative (dV/dT) of the volume-threshold function in PET-CT images of the whole tumor. The relationship between intratumoral heterogeneity and NPC diagnosis (SUVmax, tumor volume, staging, etc) was determined for this cohort. To study the correlation between the findings of MR and PET, MR images, including T1W, T2W, post-contrast T1W images were registered to PET images by using the software SPM 5 or FSL. Voxel-based correlation between signal intensity in registered MR and PET images was performed for each patient within the ROI automatically drawn in PET applying a threshold of 40% SUVmax. It was found that the heterogeneity reflected by PET significantly correlated with tumor volume, M-stage, AJCC stage, and SUVmax (p<0.05); but not with T-stage (p=0.069) and N-stage (p=0.063). However, only in part of this cohort, significantly positive or negative correlation was found (9 in 26 cases, between T1W and PET; 19 in 26, between T2W and PET; 13 in 26, between post-contrast T1W and PET), with weak correlation coefficients (-0.2060.439). In conclusion, the intratumoral heterogeneity of FDG uptake has significant correlation with tumor volume, SUVmax and staging, but no or weak relationship with heterogeneity of MRI signal intensity and contrast enhancement. This finding may help to improve the characterization of NPC, while the value of intratumoral heterogeneity in NPC prognosis remains to be studied.
DescriptionPoster Session 1C: In Vivo Studies & Development/Novel Use of Imaging Probes - Clinical Studies: Presentation No. 0736A
Persistent Identifierhttp://hdl.handle.net/10722/140189

 

DC FieldValueLanguage
dc.contributor.authorHuang, Ben_US
dc.contributor.authorKhong, PLen_US
dc.contributor.authorKwong, DLWen_US
dc.contributor.authorChan, WKSen_US
dc.date.accessioned2011-09-23T06:08:23Z-
dc.date.available2011-09-23T06:08:23Z-
dc.date.issued2010en_US
dc.identifier.citationThe 2010 World Molecular Imaging Congress (WMIC 2010), Kyoto, Japan, 8-11 September 2010.en_US
dc.identifier.urihttp://hdl.handle.net/10722/140189-
dc.descriptionPoster Session 1C: In Vivo Studies & Development/Novel Use of Imaging Probes - Clinical Studies: Presentation No. 0736A-
dc.description.abstractTumors are heterogeneous due to cellular proliferation, necrosis, noncellular accumulations and physiologic characteristics, etc. It has been reported that heterogeneity is related to outcome, and studying its evolution may help to optimize treatment planning. We aimed to study the role of tumor heterogeneity reflected by PET-CT in the diagnosis of Nasopharyngeal Carcinoma (NPC), a leading cancer type in South China, and the correlation with MRI findings. It was hypothesized that tumor heterogeneity reflected by PET-CT correlated with both NPC diagnosis (SUVmax, tumor volume, stage, etc) and heterogeneity reflected by MRI scanning. A total of 26 newly-diagnosed NPC patients who had received both PET-CT and MRI examinations (interval between PET-CT and MRI scans not longer than two weeks) with the tumor size bigger than 1.5cm in any direction were studied. Intratumoral heterogeneity was calculated by taking the derivative (dV/dT) of the volume-threshold function in PET-CT images of the whole tumor. The relationship between intratumoral heterogeneity and NPC diagnosis (SUVmax, tumor volume, staging, etc) was determined for this cohort. To study the correlation between the findings of MR and PET, MR images, including T1W, T2W, post-contrast T1W images were registered to PET images by using the software SPM 5 or FSL. Voxel-based correlation between signal intensity in registered MR and PET images was performed for each patient within the ROI automatically drawn in PET applying a threshold of 40% SUVmax. It was found that the heterogeneity reflected by PET significantly correlated with tumor volume, M-stage, AJCC stage, and SUVmax (p<0.05); but not with T-stage (p=0.069) and N-stage (p=0.063). However, only in part of this cohort, significantly positive or negative correlation was found (9 in 26 cases, between T1W and PET; 19 in 26, between T2W and PET; 13 in 26, between post-contrast T1W and PET), with weak correlation coefficients (-0.2060.439). In conclusion, the intratumoral heterogeneity of FDG uptake has significant correlation with tumor volume, SUVmax and staging, but no or weak relationship with heterogeneity of MRI signal intensity and contrast enhancement. This finding may help to improve the characterization of NPC, while the value of intratumoral heterogeneity in NPC prognosis remains to be studied.-
dc.languageengen_US
dc.relation.ispartofWorld Molecular Imaging Congress, WMIC 2010en_US
dc.titleInvestigation of intratumoral heterogeneity in nasopharyngeal carcinoma: a distinct role of PET-CT from MRIen_US
dc.typeConference_Paperen_US
dc.identifier.emailHuang, B: huangbs@gmail.comen_US
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hken_US
dc.identifier.emailKwong, DLW: dlwkwong@hku.hk-
dc.identifier.emailChan, WKS: kitsum80@gamil.com-
dc.identifier.authorityKhong, PL=rp00467en_US
dc.identifier.authorityKwong, DLW=rp00414en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros192214en_US
dc.description.otherThe 2010 World Molecular Imaging Congress (WMIC 2010), Kyoto, Japan, 8-11 September 2010.-

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