Book: Microarrays for personalized genomic medicine

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TitleMicroarrays for personalized genomic medicine
AuthorsLam, CW1
Lau, KC1
Tong, SF1
Issue Date2010
PublisherAcademic Press.
CitationAdvances In Clinical Chemistry, 2010, v. 52 C, p. 1-18 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0065-2423(10)52001-8
AbstractThe combination of single nucleotide polymorphisms (SNPs) database and high-density SNP array allows the use of SNPs as informative polymorphic markers for Mendelian diseases with complex traits efficiently. With the high-density and high-resolution SNP arrays, we can detect even the smallest structural changes that would have been missed with conventional low-density cytogenetic techniques for prognostic and diagnostic utilities. Accurate mapping may be useful for genotype-phenotype correlation in individual basis and for prenatal investigations. Here, we review some applications of genome-wide SNP genotyping on detecting homozygous candidate region in consanguineous family priors to mutation analysis. In addition to personalized genomic medicine, studying the genetic heterogeneity in diverse ancestral population helps to implementing effective clinical management. © 2010 Elsevier Inc.
ISSN0065-2423
2011 Impact Factor: 3.205
2011 SCImago Journal Rankings: 0.288
DOIhttp://dx.doi.org/10.1016/S0065-2423(10)52001-8
ISI Accession Number IDWOS:000283462500001
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLam, CW
dc.contributor.authorLau, KC
dc.contributor.authorTong, SF
dc.date.accessioned2011-09-23T06:01:33Z
dc.date.available2011-09-23T06:01:33Z
dc.date.issued2010
dc.description.abstractThe combination of single nucleotide polymorphisms (SNPs) database and high-density SNP array allows the use of SNPs as informative polymorphic markers for Mendelian diseases with complex traits efficiently. With the high-density and high-resolution SNP arrays, we can detect even the smallest structural changes that would have been missed with conventional low-density cytogenetic techniques for prognostic and diagnostic utilities. Accurate mapping may be useful for genotype-phenotype correlation in individual basis and for prenatal investigations. Here, we review some applications of genome-wide SNP genotyping on detecting homozygous candidate region in consanguineous family priors to mutation analysis. In addition to personalized genomic medicine, studying the genetic heterogeneity in diverse ancestral population helps to implementing effective clinical management. © 2010 Elsevier Inc.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAdvances In Clinical Chemistry, 2010, v. 52 C, p. 1-18 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0065-2423(10)52001-8
dc.identifier.doihttp://dx.doi.org/10.1016/S0065-2423(10)52001-8
dc.identifier.epage18
dc.identifier.hkuros192460
dc.identifier.isiWOS:000283462500001
dc.identifier.issn0065-2423
2011 Impact Factor: 3.205
2011 SCImago Journal Rankings: 0.288
dc.identifier.issueC
dc.identifier.pmid21275337
dc.identifier.scopuseid_2-s2.0-77956997886
dc.identifier.spage1
dc.identifier.urihttp://hdl.handle.net/10722/139926
dc.identifier.volume52
dc.languageeng
dc.publisherAcademic Press.
dc.publisher.placeUnited States
dc.relation.ispartofAdvances in Clinical Chemistry
dc.relation.referencesReferences in Scopus
dc.subject.meshGenetic Testing - methods
dc.subject.meshGenomics - methods
dc.subject.meshGenotype
dc.subject.meshMicroarray Analysis - methods
dc.subject.meshPolymorphism, Single Nucleotide
dc.titleMicroarrays for personalized genomic medicine
dc.typeBook
Author Affiliations
  1. The University of Hong Kong