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Article: Haemoglobin Bonn in a Chinese family as a cause of spurious hypoxaemia measured by pulse oximetry

TitleHaemoglobin Bonn in a Chinese family as a cause of spurious hypoxaemia measured by pulse oximetry
Authors
Issue Date2010
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 2010, v. 63 n. 10, p. 947-949 How to Cite?
AbstractHaemoglobin (Hb) Bonn is a newly described benign Hb variant that causes falsely depressed oxygen saturation as measured by pulse oximetry. It was found to be associated with mild haemolysis. Since its first report in a German family, no further cases have been documented in the literature. We report the first Chinese family with this Hb variant and confirm its unusual clinical presentation. No evidence of haemolysis was seen. The absence of consistent abnormalities in routine Hb tests such as high-performance liquid chromatography and gel electrophoresis means that spurious hypoxaemia is the only clue to its presence, and genotypic analysis is the preferred method for definitive diagnosis. Its positive identification is important for counselling and will help to avoid unnecessary investigation and treatment for this benign condition.
Persistent Identifierhttp://hdl.handle.net/10722/139917
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSo, CCen_HK
dc.contributor.authorChan, AYen_HK
dc.contributor.authorChow, EYen_HK
dc.contributor.authorLin, SYen_HK
dc.contributor.authorYip, SFen_HK
dc.contributor.authorSzeto, SCen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2011-09-23T06:01:11Z-
dc.date.available2011-09-23T06:01:11Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Clinical Pathology, 2010, v. 63 n. 10, p. 947-949en_HK
dc.identifier.issn0021-9746en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139917-
dc.description.abstractHaemoglobin (Hb) Bonn is a newly described benign Hb variant that causes falsely depressed oxygen saturation as measured by pulse oximetry. It was found to be associated with mild haemolysis. Since its first report in a German family, no further cases have been documented in the literature. We report the first Chinese family with this Hb variant and confirm its unusual clinical presentation. No evidence of haemolysis was seen. The absence of consistent abnormalities in routine Hb tests such as high-performance liquid chromatography and gel electrophoresis means that spurious hypoxaemia is the only clue to its presence, and genotypic analysis is the preferred method for definitive diagnosis. Its positive identification is important for counselling and will help to avoid unnecessary investigation and treatment for this benign condition.en_HK
dc.languageengen_US
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_HK
dc.relation.ispartofJournal of Clinical Pathologyen_HK
dc.rightsJournal of Clinical Pathology. Copyright © BMJ Publishing Group.-
dc.subject.meshAnoxia - diagnosis - etiology-
dc.subject.meshHemoglobinopathies - complications - diagnosis-
dc.subject.meshHemoglobins, Abnormal - analysis - genetics-
dc.subject.meshOximetry-
dc.subject.meshOxygen - blood-
dc.titleHaemoglobin Bonn in a Chinese family as a cause of spurious hypoxaemia measured by pulse oximetryen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, CC:scc@pathology.hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authoritySo, CC=rp00391en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1136/jcp.2010.078147en_HK
dc.identifier.pmid20876330-
dc.identifier.scopuseid_2-s2.0-77957855136en_HK
dc.identifier.hkuros192298en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957855136&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume63en_HK
dc.identifier.issue10en_HK
dc.identifier.spage947en_HK
dc.identifier.epage949en_HK
dc.identifier.isiWOS:000282168400017-
dc.publisher.placeUnited Kingdomen_HK

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