Article: Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice
| Title | Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Authors | Xi, W4 Lee, CKF2 Yeung, WSB2 Giesy, JP1 3 Wong, MH4 Zhang, X1 Hecker, M1 Wong, CKC4 | ||||||||
| Keywords | Gonadotrophin GPR-54 Kisspeptin Steroidogenesis | ||||||||
| Issue Date | 2011 | ||||||||
| Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/reprotox | ||||||||
| Citation | Reproductive Toxicology, 2011, v. 31 n. 4, p. 409-417 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.reprotox.2010.12.002 | ||||||||
| Abstract | Bisphenol A (BPA) is used in the manufacture of many products and is ubiquitous in the environment. Adverse effects of BPA on animal reproductive health have been reported, however most of the studies relied on the approaches in the assessment of conventional histology and anatomical features. The mechanistic actions of BPA are not clear. In the present study, a murine model was used to study potential effects of BPA exposure during perinatal and postnatal periods on endocrine functions of hypothalamic-pituitary-gonadal (HPG)-axis. At the hypothalamic-pituitary level, BPA exposure resulted in the up-regulation of the expression levels of KiSS-1, GnRH and FSH mRNA in both male and female pups. At the gonadal levels, BPA caused inhibition in the expressions of testicular steroidogenic enzymes and the synthesis of testosterone in the male pups. Conversely exposure to BPA resulted in a greater aromatase expression level and the synthesis of estrogen in the female pups. BPA is a weak estrogen agonist and its effects reported on animal studies are difficult to reconcile with mechanistic action of estrogen. In this study we hypothesized that the effects of BPA on reproductive dysfunction may be due to its actions on gonadal steroidogenesis and so the anomalous releases of endogenous steroid hormones. This non-ER-mediated effect is more potent in affecting the feedback regulatory circuits in the HPG-axis. © 2010 Elsevier Inc. | ||||||||
| ISSN | 0890-6238 2011 Impact Factor: 3.226 2011 SCImago Journal Rankings: 0.209 | ||||||||
| DOI | http://dx.doi.org/10.1016/j.reprotox.2010.12.002 | ||||||||
| ISI Accession Number ID | WOS:000291377200005
Funding Information: This work was supported by the Super Faculty Research Grant, Hong Kong Baptist University (CKC Wong) and Collaborative Research Fund (HKBU 1/CRF/08), University Grants Committee. Prof. Giesy was supported by the Canada Research Chair program and an at large Chair Professorship at the Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong. | ||||||||
| References | References in Scopus |
| dc.contributor.author | Xi, W | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Lee, CKF | ||||||||
| dc.contributor.author | Yeung, WSB | ||||||||
| dc.contributor.author | Giesy, JP | ||||||||
| dc.contributor.author | Wong, MH | ||||||||
| dc.contributor.author | Zhang, X | ||||||||
| dc.contributor.author | Hecker, M | ||||||||
| dc.contributor.author | Wong, CKC | ||||||||
| dc.date.accessioned | 2011-09-23T05:59:58Z | ||||||||
| dc.date.available | 2011-09-23T05:59:58Z | ||||||||
| dc.date.issued | 2011 | ||||||||
| dc.description.abstract | Bisphenol A (BPA) is used in the manufacture of many products and is ubiquitous in the environment. Adverse effects of BPA on animal reproductive health have been reported, however most of the studies relied on the approaches in the assessment of conventional histology and anatomical features. The mechanistic actions of BPA are not clear. In the present study, a murine model was used to study potential effects of BPA exposure during perinatal and postnatal periods on endocrine functions of hypothalamic-pituitary-gonadal (HPG)-axis. At the hypothalamic-pituitary level, BPA exposure resulted in the up-regulation of the expression levels of KiSS-1, GnRH and FSH mRNA in both male and female pups. At the gonadal levels, BPA caused inhibition in the expressions of testicular steroidogenic enzymes and the synthesis of testosterone in the male pups. Conversely exposure to BPA resulted in a greater aromatase expression level and the synthesis of estrogen in the female pups. BPA is a weak estrogen agonist and its effects reported on animal studies are difficult to reconcile with mechanistic action of estrogen. In this study we hypothesized that the effects of BPA on reproductive dysfunction may be due to its actions on gonadal steroidogenesis and so the anomalous releases of endogenous steroid hormones. This non-ER-mediated effect is more potent in affecting the feedback regulatory circuits in the HPG-axis. © 2010 Elsevier Inc. | ||||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||||
| dc.identifier.citation | Reproductive Toxicology, 2011, v. 31 n. 4, p. 409-417 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.reprotox.2010.12.002 | ||||||||
| dc.identifier.citeulike | 8611783 | ||||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.reprotox.2010.12.002 | ||||||||
| dc.identifier.epage | 417 | ||||||||
| dc.identifier.hkuros | 196016 | ||||||||
| dc.identifier.isi | WOS:000291377200005
Funding Information: This work was supported by the Super Faculty Research Grant, Hong Kong Baptist University (CKC Wong) and Collaborative Research Fund (HKBU 1/CRF/08), University Grants Committee. Prof. Giesy was supported by the Canada Research Chair program and an at large Chair Professorship at the Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong. | ||||||||
| dc.identifier.issn | 0890-6238 2011 Impact Factor: 3.226 2011 SCImago Journal Rankings: 0.209 | ||||||||
| dc.identifier.issue | 4 | ||||||||
| dc.identifier.pmid | 21182934 | ||||||||
| dc.identifier.scopus | eid_2-s2.0-79956370282 | ||||||||
| dc.identifier.spage | 409 | ||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/139903 | ||||||||
| dc.identifier.volume | 31 | ||||||||
| dc.language | eng | ||||||||
| dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/reprotox | ||||||||
| dc.publisher.place | United States | ||||||||
| dc.relation.ispartof | Reproductive Toxicology | ||||||||
| dc.relation.references | References in Scopus | ||||||||
| dc.subject.mesh | Endocrine Disruptors - toxicity | ||||||||
| dc.subject.mesh | Environmental Pollutants - toxicity | ||||||||
| dc.subject.mesh | Hypothalamo-Hypophyseal System - drug effects - growth and development - metabolism | ||||||||
| dc.subject.mesh | Ovary - drug effects - growth and development - metabolism | ||||||||
| dc.subject.mesh | Testis - drug effects - growth and development - metabolism | ||||||||
| dc.subject | Gonadotrophin | ||||||||
| dc.subject | GPR-54 | ||||||||
| dc.subject | Kisspeptin | ||||||||
| dc.subject | Steroidogenesis | ||||||||
| dc.title | Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice | ||||||||
| dc.type | Article |
Author Affiliations
- University of Saskatchewan
- The University of Hong Kong
- City University of Hong Kong
- Hong Kong Baptist University