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Article: Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice
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TitleEffect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice
 
AuthorsXi, W3
Lee, CKF2
Yeung, WSB2
Giesy, JP1 4
Wong, MH3
Zhang, X1
Hecker, M1
Wong, CKC3
 
KeywordsGonadotrophin
GPR-54
Kisspeptin
Steroidogenesis
 
Issue Date2011
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/reprotox
 
CitationReproductive Toxicology, 2011, v. 31 n. 4, p. 409-417 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.reprotox.2010.12.002
 
AbstractBisphenol A (BPA) is used in the manufacture of many products and is ubiquitous in the environment. Adverse effects of BPA on animal reproductive health have been reported, however most of the studies relied on the approaches in the assessment of conventional histology and anatomical features. The mechanistic actions of BPA are not clear. In the present study, a murine model was used to study potential effects of BPA exposure during perinatal and postnatal periods on endocrine functions of hypothalamic-pituitary-gonadal (HPG)-axis. At the hypothalamic-pituitary level, BPA exposure resulted in the up-regulation of the expression levels of KiSS-1, GnRH and FSH mRNA in both male and female pups. At the gonadal levels, BPA caused inhibition in the expressions of testicular steroidogenic enzymes and the synthesis of testosterone in the male pups. Conversely exposure to BPA resulted in a greater aromatase expression level and the synthesis of estrogen in the female pups. BPA is a weak estrogen agonist and its effects reported on animal studies are difficult to reconcile with mechanistic action of estrogen. In this study we hypothesized that the effects of BPA on reproductive dysfunction may be due to its actions on gonadal steroidogenesis and so the anomalous releases of endogenous steroid hormones. This non-ER-mediated effect is more potent in affecting the feedback regulatory circuits in the HPG-axis. © 2010 Elsevier Inc.
 
ISSN0890-6238
2013 Impact Factor: 2.771
2013 SCImago Journal Rankings: 1.021
 
DOIhttp://dx.doi.org/10.1016/j.reprotox.2010.12.002
 
ISI Accession Number IDWOS:000291377200005
Funding AgencyGrant Number
Hong Kong Baptist University
University Grants CommitteeHKBU 1/CRF/08
Canada Research Chair program
Funding Information:

This work was supported by the Super Faculty Research Grant, Hong Kong Baptist University (CKC Wong) and Collaborative Research Fund (HKBU 1/CRF/08), University Grants Committee. Prof. Giesy was supported by the Canada Research Chair program and an at large Chair Professorship at the Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorXi, W
 
dc.contributor.authorLee, CKF
 
dc.contributor.authorYeung, WSB
 
dc.contributor.authorGiesy, JP
 
dc.contributor.authorWong, MH
 
dc.contributor.authorZhang, X
 
dc.contributor.authorHecker, M
 
dc.contributor.authorWong, CKC
 
dc.date.accessioned2011-09-23T05:59:58Z
 
dc.date.available2011-09-23T05:59:58Z
 
dc.date.issued2011
 
dc.description.abstractBisphenol A (BPA) is used in the manufacture of many products and is ubiquitous in the environment. Adverse effects of BPA on animal reproductive health have been reported, however most of the studies relied on the approaches in the assessment of conventional histology and anatomical features. The mechanistic actions of BPA are not clear. In the present study, a murine model was used to study potential effects of BPA exposure during perinatal and postnatal periods on endocrine functions of hypothalamic-pituitary-gonadal (HPG)-axis. At the hypothalamic-pituitary level, BPA exposure resulted in the up-regulation of the expression levels of KiSS-1, GnRH and FSH mRNA in both male and female pups. At the gonadal levels, BPA caused inhibition in the expressions of testicular steroidogenic enzymes and the synthesis of testosterone in the male pups. Conversely exposure to BPA resulted in a greater aromatase expression level and the synthesis of estrogen in the female pups. BPA is a weak estrogen agonist and its effects reported on animal studies are difficult to reconcile with mechanistic action of estrogen. In this study we hypothesized that the effects of BPA on reproductive dysfunction may be due to its actions on gonadal steroidogenesis and so the anomalous releases of endogenous steroid hormones. This non-ER-mediated effect is more potent in affecting the feedback regulatory circuits in the HPG-axis. © 2010 Elsevier Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationReproductive Toxicology, 2011, v. 31 n. 4, p. 409-417 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.reprotox.2010.12.002
 
dc.identifier.citeulike8611783
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.reprotox.2010.12.002
 
dc.identifier.epage417
 
dc.identifier.hkuros196016
 
dc.identifier.isiWOS:000291377200005
Funding AgencyGrant Number
Hong Kong Baptist University
University Grants CommitteeHKBU 1/CRF/08
Canada Research Chair program
Funding Information:

This work was supported by the Super Faculty Research Grant, Hong Kong Baptist University (CKC Wong) and Collaborative Research Fund (HKBU 1/CRF/08), University Grants Committee. Prof. Giesy was supported by the Canada Research Chair program and an at large Chair Professorship at the Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong.

 
dc.identifier.issn0890-6238
2013 Impact Factor: 2.771
2013 SCImago Journal Rankings: 1.021
 
dc.identifier.issue4
 
dc.identifier.pmid21182934
 
dc.identifier.scopuseid_2-s2.0-79956370282
 
dc.identifier.spage409
 
dc.identifier.urihttp://hdl.handle.net/10722/139903
 
dc.identifier.volume31
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/reprotox
 
dc.publisher.placeUnited States
 
dc.relation.ispartofReproductive Toxicology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshEndocrine Disruptors - toxicity
 
dc.subject.meshEnvironmental Pollutants - toxicity
 
dc.subject.meshHypothalamo-Hypophyseal System - drug effects - growth and development - metabolism
 
dc.subject.meshOvary - drug effects - growth and development - metabolism
 
dc.subject.meshTestis - drug effects - growth and development - metabolism
 
dc.subjectGonadotrophin
 
dc.subjectGPR-54
 
dc.subjectKisspeptin
 
dc.subjectSteroidogenesis
 
dc.titleEffect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus-pituitary-gonadal axis of CD-1 mice
 
dc.typeArticle
 
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Author Affiliations
  1. University of Saskatchewan
  2. The University of Hong Kong
  3. Hong Kong Baptist University
  4. City University of Hong Kong