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Article: Testicular signaling is the potential target of perfluorooctanesulfonate-mediated subfertility in male mice
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TitleTesticular signaling is the potential target of perfluorooctanesulfonate-mediated subfertility in male mice
 
AuthorsWan, HT3
Zhao, YG3
Wong, MH3
Lee, KF2
Yeung, WSB2
Giesy, JP1 4
Wong, CKC3
 
KeywordsEnvironment
Gene regulation
Male sexual function
Sperm
 
Issue Date2011
 
PublisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/
 
CitationBiology Of Reproduction, 2011, v. 84 n. 5, p. 1016-1023 [How to Cite?]
DOI: http://dx.doi.org/10.1095/biolreprod.110.089219
 
AbstractPerfluorooctanesulfonate (PFOS) was produced and used by various industries and in consumer products. Because of its persistence, it is ubiquitous in air, water, soil, wildlife, and humans. Although the adverse effects of PFOS on male fertility have been reported, the underlying mechanisms have not yet been elucidated. Here, for the first time, the effects of PFOS on testicular signaling, such as gonadotropin, growth hormone, insulin-like growth factor, and inhibins/activins were shown to be directly related to male subfertility. Sexually mature 8-wk-old CD1 male mice were administered by gavages in corn oil daily with 0, 1, 5, or 10 mg/kg PFOS for 7, 14, or 21 days. Serum concentrations of testosterone and epididymal sperm counts were significantly lower in the mice after 21 days of the exposure to the highest dose compared with the controls. The expression levels of testicular receptors for gonadotropin, growth hormone, and insulin-like growth factor 1 were considerably reduced on Day 21 in mice exposed daily to 10 or 5 mg/kg PFOS. The transcript levels of the subunits of the testicular factors (i.e., inhibins and activins), Inha, Inhba, and Inhbb, were significantly lower on Day 21 of daily exposure to 10, 5, or 1 mg/kg PFOS. The mRNA expression levels of steroidogenic enzymes (i.e., StAR, CYP11A1, CYP17A1, 3beta-HSD, and 17beta-HSD) were notably reduced. Therefore, PFOSelicited subfertility in male mice is manifested as progressive deterioration of testicular signaling. © 2011 by the Society for the Study of Reproduction, Inc.
 
ISSN0006-3363
2013 Impact Factor: 3.451
 
DOIhttp://dx.doi.org/10.1095/biolreprod.110.089219
 
ISI Accession Number IDWOS:000289728600021
Funding AgencyGrant Number
Hong Kong Baptist UniversityHKBU 1/CRF/08
University Grants Committee
Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong
Funding Information:

Supported by the Super Faculty Research Grant, Hong Kong Baptist University and Collaborative Research Fund (HKBU 1/CRF/08), University Grants Committee, to C.K.C.W. J.P.G. was supported by the Canada Research Chair program and an at-large Chair Professorship at the Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWan, HT
 
dc.contributor.authorZhao, YG
 
dc.contributor.authorWong, MH
 
dc.contributor.authorLee, KF
 
dc.contributor.authorYeung, WSB
 
dc.contributor.authorGiesy, JP
 
dc.contributor.authorWong, CKC
 
dc.date.accessioned2011-09-23T05:59:49Z
 
dc.date.available2011-09-23T05:59:49Z
 
dc.date.issued2011
 
dc.description.abstractPerfluorooctanesulfonate (PFOS) was produced and used by various industries and in consumer products. Because of its persistence, it is ubiquitous in air, water, soil, wildlife, and humans. Although the adverse effects of PFOS on male fertility have been reported, the underlying mechanisms have not yet been elucidated. Here, for the first time, the effects of PFOS on testicular signaling, such as gonadotropin, growth hormone, insulin-like growth factor, and inhibins/activins were shown to be directly related to male subfertility. Sexually mature 8-wk-old CD1 male mice were administered by gavages in corn oil daily with 0, 1, 5, or 10 mg/kg PFOS for 7, 14, or 21 days. Serum concentrations of testosterone and epididymal sperm counts were significantly lower in the mice after 21 days of the exposure to the highest dose compared with the controls. The expression levels of testicular receptors for gonadotropin, growth hormone, and insulin-like growth factor 1 were considerably reduced on Day 21 in mice exposed daily to 10 or 5 mg/kg PFOS. The transcript levels of the subunits of the testicular factors (i.e., inhibins and activins), Inha, Inhba, and Inhbb, were significantly lower on Day 21 of daily exposure to 10, 5, or 1 mg/kg PFOS. The mRNA expression levels of steroidogenic enzymes (i.e., StAR, CYP11A1, CYP17A1, 3beta-HSD, and 17beta-HSD) were notably reduced. Therefore, PFOSelicited subfertility in male mice is manifested as progressive deterioration of testicular signaling. © 2011 by the Society for the Study of Reproduction, Inc.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationBiology Of Reproduction, 2011, v. 84 n. 5, p. 1016-1023 [How to Cite?]
DOI: http://dx.doi.org/10.1095/biolreprod.110.089219
 
dc.identifier.doihttp://dx.doi.org/10.1095/biolreprod.110.089219
 
dc.identifier.epage1023
 
dc.identifier.hkuros195569
 
dc.identifier.isiWOS:000289728600021
Funding AgencyGrant Number
Hong Kong Baptist UniversityHKBU 1/CRF/08
University Grants Committee
Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong
Funding Information:

Supported by the Super Faculty Research Grant, Hong Kong Baptist University and Collaborative Research Fund (HKBU 1/CRF/08), University Grants Committee, to C.K.C.W. J.P.G. was supported by the Canada Research Chair program and an at-large Chair Professorship at the Department of Biology and Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong.

 
dc.identifier.issn0006-3363
2013 Impact Factor: 3.451
 
dc.identifier.issue5
 
dc.identifier.pmid21209418
 
dc.identifier.scopuseid_2-s2.0-79956317679
 
dc.identifier.spage1016
 
dc.identifier.urihttp://hdl.handle.net/10722/139899
 
dc.identifier.volume84
 
dc.languageeng
 
dc.publisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofBiology of Reproduction
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshEnvironmental Pollutants - administration and dosage - toxicity
 
dc.subject.meshHypothalamo-Hypophyseal System - physiology
 
dc.subject.meshInfertility, Male - chemically induced - metabolism
 
dc.subject.meshSignal Transduction - drug effects
 
dc.subject.meshTestis - physiology
 
dc.subjectEnvironment
 
dc.subjectGene regulation
 
dc.subjectMale sexual function
 
dc.subjectSperm
 
dc.titleTesticular signaling is the potential target of perfluorooctanesulfonate-mediated subfertility in male mice
 
dc.typeArticle
 
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Author Affiliations
  1. University of Saskatchewan
  2. The University of Hong Kong
  3. Hong Kong Baptist University
  4. City University of Hong Kong