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Article: Usefulness of physical fitness and the metabolic syndrome to predict vascular disease risk in older Chinese (from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort [GBCS-CVD])

TitleUsefulness of physical fitness and the metabolic syndrome to predict vascular disease risk in older Chinese (from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort [GBCS-CVD])
Authors
Issue Date2011
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
Citation
American Journal Of Cardiology, 2011, v. 108 n. 6, p. 845-850 How to Cite?
Abstract
Physical fitness can independently lower the risk of cardiovascular disease (CVD). We explored the independent and combined associations of physical fitness, measured using the seated at rest heart rate (RHR), and the metabolic syndrome (MS), with CVD risk, as described by an elevated pulse wave velocity (PWV) in older Chinese. Data from 1,996 participants were drawn from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort. Analysis of variance and logistic regression analysis were used to establish the independent and combined associations of the RHR and the MS with PWV. The RHR was independently associated with an elevated PWV (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.22 to 2.18), as was the MS (OR 2.36, 95% CI 1.76 to 3.17). The participants with a high RHR, but without the MS, had an adjusted OR of 1.63 (95% CI 1.15 to 2.30) for the presence of the CVD proxy. Those with a low RHR and the MS had an adjusted OR of 2.35 (95% CI 1.66 to 3.33). The risk of an elevated PWV increased almost fourfold with both a high RHR and a diagnosis of the MS (OR 3.87, 95% CI 2.39 to 6.28, p = 0.52 for interaction). In conclusion, physical fitness, measured using the RHR, and the MS are independently associated with an elevated PWV, a surrogate marker for CVD. The strength of this association was further increased in the presence of both. These findings confirm the beneficial effects of physical fitness on attenuating the risk of CVD among older Chinese. © 2011 Elsevier Inc. All Rights Reserved.
Persistent Identifierhttp://hdl.handle.net/10722/139876
ISSN
2013 Impact Factor: 3.425
2013 SCImago Journal Rankings: 2.315
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council (Hong Kong, China)30518001
HKU720/05
University of Hong Kong Foundation for Educational Development and Research (Hong Kong, China)
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau (Guangzhou, China)
University of Birmingham (Birmingham, United Kingdom)
Funding Information:

The Guangzhou Biobank Cohort Study was funded by grants 30518001 and HKU720/05 from the National Natural Science Foundation of China/Research Grants Council (Hong Kong, China); the University of Hong Kong Foundation for Educational Development and Research (Hong Kong, China); the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau (Guangzhou, China); and the University of Birmingham (Birmingham, United Kingdom).

References

 

Author Affiliations
  1. The University of Hong Kong
  2. Guangzhou No. 12 Hospital
  3. University of Birmingham
DC FieldValueLanguage
dc.contributor.authorO'Hartaigh, Ben_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorTsvetanov, KAen_HK
dc.contributor.authorBosch, JAen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorLam, THen_HK
dc.date.accessioned2011-09-23T05:59:06Z-
dc.date.available2011-09-23T05:59:06Z-
dc.date.issued2011en_HK
dc.identifier.citationAmerican Journal Of Cardiology, 2011, v. 108 n. 6, p. 845-850en_HK
dc.identifier.issn0002-9149en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139876-
dc.description.abstractPhysical fitness can independently lower the risk of cardiovascular disease (CVD). We explored the independent and combined associations of physical fitness, measured using the seated at rest heart rate (RHR), and the metabolic syndrome (MS), with CVD risk, as described by an elevated pulse wave velocity (PWV) in older Chinese. Data from 1,996 participants were drawn from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort. Analysis of variance and logistic regression analysis were used to establish the independent and combined associations of the RHR and the MS with PWV. The RHR was independently associated with an elevated PWV (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.22 to 2.18), as was the MS (OR 2.36, 95% CI 1.76 to 3.17). The participants with a high RHR, but without the MS, had an adjusted OR of 1.63 (95% CI 1.15 to 2.30) for the presence of the CVD proxy. Those with a low RHR and the MS had an adjusted OR of 2.35 (95% CI 1.66 to 3.33). The risk of an elevated PWV increased almost fourfold with both a high RHR and a diagnosis of the MS (OR 3.87, 95% CI 2.39 to 6.28, p = 0.52 for interaction). In conclusion, physical fitness, measured using the RHR, and the MS are independently associated with an elevated PWV, a surrogate marker for CVD. The strength of this association was further increased in the presence of both. These findings confirm the beneficial effects of physical fitness on attenuating the risk of CVD among older Chinese. © 2011 Elsevier Inc. All Rights Reserved.en_HK
dc.languageengen_US
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/en_HK
dc.relation.ispartofAmerican Journal of Cardiologyen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshCardiovascular Diseases - epidemiology - etiology - physiopathology - prevention & controlen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHeart Rate - physiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLogistic Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMetabolic Syndrome X - complications - epidemiology - physiopathologyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPhysical Fitnessen_HK
dc.subject.meshPlethysmographyen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshRisk Assessmenten_HK
dc.titleUsefulness of physical fitness and the metabolic syndrome to predict vascular disease risk in older Chinese (from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort [GBCS-CVD])en_HK
dc.typeArticleen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.amjcard.2011.05.010en_HK
dc.identifier.pmid21784386en_HK
dc.identifier.scopuseid_2-s2.0-80052297899en_HK
dc.identifier.hkuros196073en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80052297899&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume108en_HK
dc.identifier.issue6en_HK
dc.identifier.spage845en_HK
dc.identifier.epage850en_HK
dc.identifier.isiWOS:000295352700015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridO'Hartaigh, B=54389776400en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.scopusauthoridTsvetanov, KA=37018858800en_HK
dc.identifier.scopusauthoridBosch, JA=35236063200en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.citeulike9617595-

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