Article: Usefulness of physical fitness and the metabolic syndrome to predict vascular disease risk in older Chinese (from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort [GBCS-CVD])

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TitleUsefulness of physical fitness and the metabolic syndrome to predict vascular disease risk in older Chinese (from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort [GBCS-CVD])
AuthorsO'Hartaigh, B3
Jiang, CQ2
Thomas, GN3
Tsvetanov, KA3
Bosch, JA3
Cheng, KK3
Lam, TH1
Issue Date2011
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
CitationAmerican Journal Of Cardiology, 2011, v. 108 n. 6, p. 845-850 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.amjcard.2011.05.010
AbstractPhysical fitness can independently lower the risk of cardiovascular disease (CVD). We explored the independent and combined associations of physical fitness, measured using the seated at rest heart rate (RHR), and the metabolic syndrome (MS), with CVD risk, as described by an elevated pulse wave velocity (PWV) in older Chinese. Data from 1,996 participants were drawn from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort. Analysis of variance and logistic regression analysis were used to establish the independent and combined associations of the RHR and the MS with PWV. The RHR was independently associated with an elevated PWV (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.22 to 2.18), as was the MS (OR 2.36, 95% CI 1.76 to 3.17). The participants with a high RHR, but without the MS, had an adjusted OR of 1.63 (95% CI 1.15 to 2.30) for the presence of the CVD proxy. Those with a low RHR and the MS had an adjusted OR of 2.35 (95% CI 1.66 to 3.33). The risk of an elevated PWV increased almost fourfold with both a high RHR and a diagnosis of the MS (OR 3.87, 95% CI 2.39 to 6.28, p = 0.52 for interaction). In conclusion, physical fitness, measured using the RHR, and the MS are independently associated with an elevated PWV, a surrogate marker for CVD. The strength of this association was further increased in the presence of both. These findings confirm the beneficial effects of physical fitness on attenuating the risk of CVD among older Chinese. © 2011 Elsevier Inc. All Rights Reserved.
ISSN0002-9149
2011 Impact Factor: 3.368
2011 SCImago Journal Rankings: 0.371
DOIhttp://dx.doi.org/10.1016/j.amjcard.2011.05.010
ISI Accession Number IDWOS:000295352700015
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council (Hong Kong, China)30518001
HKU720/05
University of Hong Kong Foundation for Educational Development and Research (Hong Kong, China)
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau (Guangzhou, China)
University of Birmingham (Birmingham, United Kingdom)
Funding Information:

The Guangzhou Biobank Cohort Study was funded by grants 30518001 and HKU720/05 from the National Natural Science Foundation of China/Research Grants Council (Hong Kong, China); the University of Hong Kong Foundation for Educational Development and Research (Hong Kong, China); the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau (Guangzhou, China); and the University of Birmingham (Birmingham, United Kingdom).

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorO'Hartaigh, B
dc.contributor.authorJiang, CQ
dc.contributor.authorThomas, GN
dc.contributor.authorTsvetanov, KA
dc.contributor.authorBosch, JA
dc.contributor.authorCheng, KK
dc.contributor.authorLam, TH
dc.date.accessioned2011-09-23T05:59:06Z
dc.date.available2011-09-23T05:59:06Z
dc.date.issued2011
dc.description.abstractPhysical fitness can independently lower the risk of cardiovascular disease (CVD). We explored the independent and combined associations of physical fitness, measured using the seated at rest heart rate (RHR), and the metabolic syndrome (MS), with CVD risk, as described by an elevated pulse wave velocity (PWV) in older Chinese. Data from 1,996 participants were drawn from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort. Analysis of variance and logistic regression analysis were used to establish the independent and combined associations of the RHR and the MS with PWV. The RHR was independently associated with an elevated PWV (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.22 to 2.18), as was the MS (OR 2.36, 95% CI 1.76 to 3.17). The participants with a high RHR, but without the MS, had an adjusted OR of 1.63 (95% CI 1.15 to 2.30) for the presence of the CVD proxy. Those with a low RHR and the MS had an adjusted OR of 2.35 (95% CI 1.66 to 3.33). The risk of an elevated PWV increased almost fourfold with both a high RHR and a diagnosis of the MS (OR 3.87, 95% CI 2.39 to 6.28, p = 0.52 for interaction). In conclusion, physical fitness, measured using the RHR, and the MS are independently associated with an elevated PWV, a surrogate marker for CVD. The strength of this association was further increased in the presence of both. These findings confirm the beneficial effects of physical fitness on attenuating the risk of CVD among older Chinese. © 2011 Elsevier Inc. All Rights Reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAmerican Journal Of Cardiology, 2011, v. 108 n. 6, p. 845-850 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.amjcard.2011.05.010
dc.identifier.citeulike9617595
dc.identifier.doihttp://dx.doi.org/10.1016/j.amjcard.2011.05.010
dc.identifier.epage850
dc.identifier.hkuros196073
dc.identifier.isiWOS:000295352700015
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council (Hong Kong, China)30518001
HKU720/05
University of Hong Kong Foundation for Educational Development and Research (Hong Kong, China)
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau (Guangzhou, China)
University of Birmingham (Birmingham, United Kingdom)
Funding Information:

The Guangzhou Biobank Cohort Study was funded by grants 30518001 and HKU720/05 from the National Natural Science Foundation of China/Research Grants Council (Hong Kong, China); the University of Hong Kong Foundation for Educational Development and Research (Hong Kong, China); the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau (Guangzhou, China); and the University of Birmingham (Birmingham, United Kingdom).

dc.identifier.issn0002-9149
2011 Impact Factor: 3.368
2011 SCImago Journal Rankings: 0.371
dc.identifier.issue6
dc.identifier.pmid21784386
dc.identifier.scopuseid_2-s2.0-80052297899
dc.identifier.spage845
dc.identifier.urihttp://hdl.handle.net/10722/139876
dc.identifier.volume108
dc.languageeng
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
dc.publisher.placeUnited States
dc.relation.ispartofAmerican Journal of Cardiology
dc.relation.referencesReferences in Scopus
dc.subject.meshAnalysis of Variance
dc.subject.meshCardiovascular Diseases - epidemiology - etiology - physiopathology - prevention & control
dc.subject.meshChina - epidemiology
dc.subject.meshCohort Studies
dc.subject.meshFemale
dc.subject.meshHeart Rate - physiology
dc.subject.meshHumans
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMetabolic Syndrome X - complications - epidemiology - physiopathology
dc.subject.meshMiddle Aged
dc.subject.meshPhysical Fitness
dc.subject.meshPlethysmography
dc.subject.meshPredictive Value of Tests
dc.subject.meshRisk Assessment
dc.titleUsefulness of physical fitness and the metabolic syndrome to predict vascular disease risk in older Chinese (from the Guangzhou Biobank Cohort Study-Cardiovascular Disease Subcohort [GBCS-CVD])
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Guangzhou No. 12 Hospital
  3. University of Birmingham