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Article: Circulating influenza virus, climatic factors, and acute myocardial infarction: A time series study in England and Wales and Hong Kong

TitleCirculating influenza virus, climatic factors, and acute myocardial infarction: A time series study in England and Wales and Hong Kong
Authors
Issue Date2011
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2011, v. 203 n. 12, p. 1710-1718 How to Cite?
AbstractBackground. Previous studies identifying associations between influenza and acute cardiac events may have been confounded by climatic factors. Differing seasonal patterns of influenza activity in Hong Kong and England and Wales provide a natural experiment to examine associations with myocardial infarction (MI) independent of cold weather effects. Methods. Weekly clinical and laboratory influenza surveillance data, environmental temperature and humidity data, and counts of MI-associated hospitalizations and deaths were obtained for England and Wales and for Hong Kong for the period 1998-2008. We used Poisson regression models that included environmental and seasonal variables to investigate the relationship between influenza and MI. Results. There were ≥ 1.2 million MI-associated hospitalizations and 410,204 MI-associated deaths in England and Wales, with a marked peak in the winter season. In Hong Kong, the incidence of MI, on the basis of 65,108 hospitalizations and 18,780 deaths, had a large winter and smaller summer peak, mirroring patterns of influenza activity. There was strong evidence for a link between influenza and MI both in England and Wales, where 3.1%-3.4% of MI-associated deaths (P < .001) and 0.7%-1.2% of MI-associated hospitalizations (P < .001) were attributable to influenza, and in Hong Kong, where the corresponding figures were 3.9%-5.6% (P = .018) and 3.0%-3.3% (P = .002). Conclusions. Influenza was associated with an increase in MI-associated deaths and hospitalizations in 2 contrasting settings. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/139852
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Harvard Center for Communicable Disease Dynamics from the US National Institutes of Health1 U54 GM088558
Hong Kong University Grants CommitteeAoE/M-12/06
MRC
Wellcome Trust
Camden Primary Care Trust
MedImmune
Funding Information:

This work was supported in part by the Harvard Center for Communicable Disease Dynamics from the US National Institutes of Health models of Infectious Disease Agent Study program (grant 1 U54 GM088558) and the Area of Excellence Scheme of the Hong Kong University Grants Committee (grant AoE/M-12/06). C. W. G. is supported by an MRC Clinical Research Training Fellowship. L. S. holds a Wellcome Trust Senior Clinical Fellowship. A. H. is funded by Camden Primary Care Trust.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorWarrenGash, Cen_HK
dc.contributor.authorBhaskaran, Ken_HK
dc.contributor.authorHayward, Aen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorLo, SVen_HK
dc.contributor.authorWong, CMen_HK
dc.contributor.authorEllis, Jen_HK
dc.contributor.authorPebody, Ren_HK
dc.contributor.authorSmeeth, Len_HK
dc.contributor.authorCowling, BJen_HK
dc.date.accessioned2011-09-23T05:58:29Z-
dc.date.available2011-09-23T05:58:29Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2011, v. 203 n. 12, p. 1710-1718en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139852-
dc.description.abstractBackground. Previous studies identifying associations between influenza and acute cardiac events may have been confounded by climatic factors. Differing seasonal patterns of influenza activity in Hong Kong and England and Wales provide a natural experiment to examine associations with myocardial infarction (MI) independent of cold weather effects. Methods. Weekly clinical and laboratory influenza surveillance data, environmental temperature and humidity data, and counts of MI-associated hospitalizations and deaths were obtained for England and Wales and for Hong Kong for the period 1998-2008. We used Poisson regression models that included environmental and seasonal variables to investigate the relationship between influenza and MI. Results. There were ≥ 1.2 million MI-associated hospitalizations and 410,204 MI-associated deaths in England and Wales, with a marked peak in the winter season. In Hong Kong, the incidence of MI, on the basis of 65,108 hospitalizations and 18,780 deaths, had a large winter and smaller summer peak, mirroring patterns of influenza activity. There was strong evidence for a link between influenza and MI both in England and Wales, where 3.1%-3.4% of MI-associated deaths (P < .001) and 0.7%-1.2% of MI-associated hospitalizations (P < .001) were attributable to influenza, and in Hong Kong, where the corresponding figures were 3.9%-5.6% (P = .018) and 3.0%-3.3% (P = .002). Conclusions. Influenza was associated with an increase in MI-associated deaths and hospitalizations in 2 contrasting settings. © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.subject.meshClimate-
dc.subject.meshInfluenza A Virus, H3N2 Subtype-
dc.subject.meshInfluenza, Human - complications-
dc.subject.meshMyocardial Infarction - complications - epidemiology - mortality-
dc.subject.meshPoisson Distribution-
dc.titleCirculating influenza virus, climatic factors, and acute myocardial infarction: A time series study in England and Wales and Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, GM:gmleung@hku.hken_HK
dc.identifier.emailWong, CM:hrmrwcm@hkucc.hku.hken_HK
dc.identifier.emailCowling, BJ:bcowling@hku.hken_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityWong, CM=rp00338en_HK
dc.identifier.authorityCowling, BJ=rp01326en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/infdis/jir171en_HK
dc.identifier.pmid21606529-
dc.identifier.pmcidPMC3100509-
dc.identifier.scopuseid_2-s2.0-79957481487en_HK
dc.identifier.hkuros185534en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79957481487&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume203en_HK
dc.identifier.issue12en_HK
dc.identifier.spage1710en_HK
dc.identifier.epage1718en_HK
dc.identifier.isiWOS:000291062200004-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridWarrenGash, C=23471079400en_HK
dc.identifier.scopusauthoridBhaskaran, K=23007687300en_HK
dc.identifier.scopusauthoridHayward, A=35944648500en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridLo, SV=8426498400en_HK
dc.identifier.scopusauthoridWong, CM=7404954904en_HK
dc.identifier.scopusauthoridEllis, J=7402714456en_HK
dc.identifier.scopusauthoridPebody, R=6603775780en_HK
dc.identifier.scopusauthoridSmeeth, L=7003651182en_HK
dc.identifier.scopusauthoridCowling, BJ=8644765500en_HK

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