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Article: Choice of management of southern Chinese BRCA mutation carriers

TitleChoice of management of southern Chinese BRCA mutation carriers
Authors
Issue Date2010
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal Of Surgery, 2010, v. 34 n. 7, p. 1416-1426 How to Cite?
AbstractBackground: Mutations in the BRCA genes confer greater risk of developing breast, ovarian, and prostate cancer. Families carrying the mutation can have intensive surveillance and take preventative measures. This is the first report on the uptake of such interventions in Chinese mutation carriers residing in Asia. Methods: Breast and ovarian cancer index patients and family members referred for genetic counselling and testing who are found to carry the BRCA mutations were included in this multicenter study. Results: A total of 31 patients with breast and/or ovarian cancer were found to carry BRCA1 or BRCA2 mutations. Forty-one tested family members also carried the mutations. Of the females, 85.7% of the index patients opted for breast surveillance and 23.8% for prophylactic mastectomy. Of the family members, 82.4% chose breast surveillance and 17.7% had prophylactic mastectomy. The majority of index patients and family members preferred ovarian surveillance (84 and 82.4%). Amongst the index patients, 32% decided for prophylactic salpingo-oophorectomy; 17.6% of the family members who did not have history of ovarian cancer decided to have prophylactic salpingo-oophorectomy. All male index patients agreed to breast and prostate surveillance, including breast clinical examination and PSA monitoring. For those male family members found to be BRCA mutation carriers, 56.3% agreed to have breast surveillance and 66.7% agreed to have prostate surveillance. No index patient or family member agreed to any form of chemoprevention. Conclusions: Chinese BRCA mutation carriers have a higher uptake of cancer surveillance than prophylactic surgery and have a lack of interest in the use of chemoprevention drugs. © 2010 Société Internationale de Chirurgie.
Persistent Identifierhttp://hdl.handle.net/10722/139761
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, Aen_HK
dc.contributor.authorWong, CHNen_HK
dc.contributor.authorShea, Cen_HK
dc.contributor.authorSuen, DTKen_HK
dc.contributor.authorChoi, CLYen_HK
dc.date.accessioned2011-09-23T05:55:22Z-
dc.date.available2011-09-23T05:55:22Z-
dc.date.issued2010en_HK
dc.identifier.citationWorld Journal Of Surgery, 2010, v. 34 n. 7, p. 1416-1426en_HK
dc.identifier.issn0364-2313en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139761-
dc.description.abstractBackground: Mutations in the BRCA genes confer greater risk of developing breast, ovarian, and prostate cancer. Families carrying the mutation can have intensive surveillance and take preventative measures. This is the first report on the uptake of such interventions in Chinese mutation carriers residing in Asia. Methods: Breast and ovarian cancer index patients and family members referred for genetic counselling and testing who are found to carry the BRCA mutations were included in this multicenter study. Results: A total of 31 patients with breast and/or ovarian cancer were found to carry BRCA1 or BRCA2 mutations. Forty-one tested family members also carried the mutations. Of the females, 85.7% of the index patients opted for breast surveillance and 23.8% for prophylactic mastectomy. Of the family members, 82.4% chose breast surveillance and 17.7% had prophylactic mastectomy. The majority of index patients and family members preferred ovarian surveillance (84 and 82.4%). Amongst the index patients, 32% decided for prophylactic salpingo-oophorectomy; 17.6% of the family members who did not have history of ovarian cancer decided to have prophylactic salpingo-oophorectomy. All male index patients agreed to breast and prostate surveillance, including breast clinical examination and PSA monitoring. For those male family members found to be BRCA mutation carriers, 56.3% agreed to have breast surveillance and 66.7% agreed to have prostate surveillance. No index patient or family member agreed to any form of chemoprevention. Conclusions: Chinese BRCA mutation carriers have a higher uptake of cancer surveillance than prophylactic surgery and have a lack of interest in the use of chemoprevention drugs. © 2010 Société Internationale de Chirurgie.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/en_HK
dc.relation.ispartofWorld Journal of Surgeryen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subject.meshAntineoplastic Agents - therapeutic use-
dc.subject.meshBreast Neoplasms - genetics - prevention and control - surgery-
dc.subject.meshBreast Neoplasms, Male - genetics - prevention and control - surgery-
dc.subject.meshOvarian Neoplasms - genetics - prevention and control - surgery-
dc.subject.meshPopulation Surveillance-
dc.titleChoice of management of southern Chinese BRCA mutation carriersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0364-2313&volume=34&issue=7&spage=1416&epage=1426&date=2010&atitle=Choice+of+management+of+Southern+Chinese+BRCA+mutation+carriers-
dc.identifier.emailKwong, A: avakwong@hkucc.hku.hken_HK
dc.identifier.authorityKwong, A=rp01734en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00268-010-0477-5en_HK
dc.identifier.pmid20182723-
dc.identifier.scopuseid_2-s2.0-77955469386en_HK
dc.identifier.hkuros169805en_US
dc.identifier.hkuros194714-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955469386&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume34en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1416en_HK
dc.identifier.epage1426en_HK
dc.identifier.isiWOS:000279103400004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, A=8913654300en_HK
dc.identifier.scopusauthoridWong, CHN=36447063800en_HK
dc.identifier.scopusauthoridShea, C=36446613000en_HK
dc.identifier.scopusauthoridSuen, DTK=8876971300en_HK
dc.identifier.scopusauthoridChoi, CLY=36024878500en_HK
dc.identifier.citeulike6782782-

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