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Article: Natural course and tumor doubling time of nasopharyngeal carcinoma. A study of 15 patients

TitleNatural course and tumor doubling time of nasopharyngeal carcinoma. A study of 15 patients
Authors
KeywordsNasopharyngeal carcinoma
Natural history
Tumor doubling time
Tumor growth rate
Untreated
Issue Date2011
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncology
Citation
Oral Oncology, 2011, v. 47 n. 8, p. 742-746 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is a non-lymphomatous carcinoma that develops in the epithelial lining of the nasopharynx. The knowledge of natural course of tumor progression has been based on anatomical model without clinical correlation. This study is the first to describe and analyze the natural progression of NPC based on clinical information and calculate the tumor growth rate of NPC. Fifteen NPC patients who refused treatment after initial work-up and then subsequent re-presentation at a later time were recruited during the period from January 2003 to August 2009. Clinical data were analyzed and CT scans were used to calculate the tumor volumes. The time interval between the first planning CT image and the subsequent planning CT image was used to calculate the rate of tumor growth in this group of patients. The tumor volume doubling time can be calculated by using the formula DT=tln2/(lnV2-lnV1), where t is the time interval between measurements and V 2 and V 1 are the tumor volumes at the end and beginning of the time interval, respectively. Cranial nerves palsies such as diplopia and systemic upset were the most common reason for re-presentation and the consent for treatment. The median growth rate was 1.63 mm 3 per day and the median tumor doubling time was 279 days. This study is the first report in the literature looking at the natural progression of nasopharyngeal carcinoma (NPC) based on clinical information. The current study showed that NPC has a propensity to grow superiorly to involve the skull base rather than laterally or anteriorly. Although the tumor growth rate was very variable, the median natural NPC growth rate was 1.63 mm 3/day. © 2011 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/139752
ISSN
2015 Impact Factor: 4.286
2015 SCImago Journal Rankings: 1.764
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, ACWen_HK
dc.contributor.authorLee, VHFen_HK
dc.contributor.authorTo, VSHen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorWei, WIen_HK
dc.date.accessioned2011-09-23T05:55:14Z-
dc.date.available2011-09-23T05:55:14Z-
dc.date.issued2011en_HK
dc.identifier.citationOral Oncology, 2011, v. 47 n. 8, p. 742-746en_HK
dc.identifier.issn1368-8375en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139752-
dc.description.abstractNasopharyngeal carcinoma (NPC) is a non-lymphomatous carcinoma that develops in the epithelial lining of the nasopharynx. The knowledge of natural course of tumor progression has been based on anatomical model without clinical correlation. This study is the first to describe and analyze the natural progression of NPC based on clinical information and calculate the tumor growth rate of NPC. Fifteen NPC patients who refused treatment after initial work-up and then subsequent re-presentation at a later time were recruited during the period from January 2003 to August 2009. Clinical data were analyzed and CT scans were used to calculate the tumor volumes. The time interval between the first planning CT image and the subsequent planning CT image was used to calculate the rate of tumor growth in this group of patients. The tumor volume doubling time can be calculated by using the formula DT=tln2/(lnV2-lnV1), where t is the time interval between measurements and V 2 and V 1 are the tumor volumes at the end and beginning of the time interval, respectively. Cranial nerves palsies such as diplopia and systemic upset were the most common reason for re-presentation and the consent for treatment. The median growth rate was 1.63 mm 3 per day and the median tumor doubling time was 279 days. This study is the first report in the literature looking at the natural progression of nasopharyngeal carcinoma (NPC) based on clinical information. The current study showed that NPC has a propensity to grow superiorly to involve the skull base rather than laterally or anteriorly. Although the tumor growth rate was very variable, the median natural NPC growth rate was 1.63 mm 3/day. © 2011 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncologyen_HK
dc.relation.ispartofOral Oncologyen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectNatural historyen_HK
dc.subjectTumor doubling timeen_HK
dc.subjectTumor growth rateen_HK
dc.subjectUntreateden_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshDisease Progressionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - pathology - radiographyen_HK
dc.subject.meshTomography, X-Ray Computed - methodsen_HK
dc.titleNatural course and tumor doubling time of nasopharyngeal carcinoma. A study of 15 patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1368-8375 (Print) 1368-8375 (Linking)&volume=47&issue=8&spage=742&epage=6&date=2011&atitle=Natural+course+and+tumor+doubling+time+of+nasopharyngeal+carcinoma.+A+study+of+15+patientsen_US
dc.identifier.emailLee, VHF: vhflee@hkucc.hku.hken_HK
dc.identifier.emailTo, VSH: doctorto@hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.emailWei, WI: hrmswwi@hku.hken_HK
dc.identifier.authorityLee, VHF=rp00264en_HK
dc.identifier.authorityTo, VSH=rp01385en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityWei, WI=rp00323en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.oraloncology.2011.06.001en_HK
dc.identifier.pmid21708482-
dc.identifier.scopuseid_2-s2.0-79960697623en_HK
dc.identifier.hkuros192658en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960697623&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue8en_HK
dc.identifier.spage742en_HK
dc.identifier.epage746en_HK
dc.identifier.eissn1879-0593-
dc.identifier.isiWOS:000293002800013-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHo, ACW=16202695800en_HK
dc.identifier.scopusauthoridLee, VHF=14035860900en_HK
dc.identifier.scopusauthoridTo, VSH=35957345400en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridWei, WI=7403321552en_HK
dc.identifier.citeulike9499617-

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