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Article: A latent contingency table approach to dose finding for combinations of two agents

TitleA latent contingency table approach to dose finding for combinations of two agents
Authors
KeywordsAdaptive design
Bayesian estimation
Combining drugs
Gibbs sampling
Maximum tolerated dose
Phase I trial
Synergy
Toxicity
Issue Date2009
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BIOM
Citation
Biometrics, 2009, v. 65 n. 3, p. 866-875 How to Cite?
AbstractSummary Two-agent combination trials have recently attracted enormous attention in oncology research. There are several strong motivations for combining different agents in a treatment: to induce the synergistic treatment effect, to increase the dose intensity with nonoverlapping toxicities, and to target different tumor cell susceptibilities. To accommodate this growing trend in clinical trials, we propose a Bayesian adaptive design for dose finding based on latent 2 × 2 tables. In the search for the maximum tolerated dose combination, we continuously update the posterior estimates for the unknown parameters associated with marginal probabilities and the correlation parameter based on the data from successive patients. By reordering the dose toxicity probabilities in the two-dimensional space, we assign each coming cohort of patients to the most appropriate dose combination. We conduct extensive simulation studies to examine the operating characteristics of the proposed method under various practical scenarios. Finally, we illustrate our dose-finding procedure with a clinical trial of agent combinations at M. D. Anderson Cancer Center. © 2008, The International Biometric Society.
Persistent Identifierhttp://hdl.handle.net/10722/139711
ISSN
2015 Impact Factor: 1.36
2015 SCImago Journal Rankings: 1.906
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYin, Gen_HK
dc.contributor.authorYuan, Yen_HK
dc.date.accessioned2011-09-23T05:54:44Z-
dc.date.available2011-09-23T05:54:44Z-
dc.date.issued2009en_HK
dc.identifier.citationBiometrics, 2009, v. 65 n. 3, p. 866-875en_HK
dc.identifier.issn0006-341Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/139711-
dc.description.abstractSummary Two-agent combination trials have recently attracted enormous attention in oncology research. There are several strong motivations for combining different agents in a treatment: to induce the synergistic treatment effect, to increase the dose intensity with nonoverlapping toxicities, and to target different tumor cell susceptibilities. To accommodate this growing trend in clinical trials, we propose a Bayesian adaptive design for dose finding based on latent 2 × 2 tables. In the search for the maximum tolerated dose combination, we continuously update the posterior estimates for the unknown parameters associated with marginal probabilities and the correlation parameter based on the data from successive patients. By reordering the dose toxicity probabilities in the two-dimensional space, we assign each coming cohort of patients to the most appropriate dose combination. We conduct extensive simulation studies to examine the operating characteristics of the proposed method under various practical scenarios. Finally, we illustrate our dose-finding procedure with a clinical trial of agent combinations at M. D. Anderson Cancer Center. © 2008, The International Biometric Society.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BIOMen_HK
dc.relation.ispartofBiometricsen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectAdaptive designen_HK
dc.subjectBayesian estimationen_HK
dc.subjectCombining drugsen_HK
dc.subjectGibbs samplingen_HK
dc.subjectMaximum tolerated doseen_HK
dc.subjectPhase I trialen_HK
dc.subjectSynergyen_HK
dc.subjectToxicityen_HK
dc.titleA latent contingency table approach to dose finding for combinations of two agentsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-341X&volume=65&issue=3&spage=866&epage=875&date=2009&atitle=A+latent+contingency+table+approach+to+dose+finding+for+combinations+of+two+agents-
dc.identifier.emailYin, G: gyin@hku.hken_HK
dc.identifier.authorityYin, G=rp00831en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1541-0420.2008.01119.xen_HK
dc.identifier.pmid18759848-
dc.identifier.scopuseid_2-s2.0-70349251729en_HK
dc.identifier.hkuros195618en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349251729&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume65en_HK
dc.identifier.issue3en_HK
dc.identifier.spage866en_HK
dc.identifier.epage875en_HK
dc.identifier.isiWOS:000269801400024-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYin, G=8725807500en_HK
dc.identifier.scopusauthoridYuan, Y=7402709174en_HK
dc.identifier.citeulike5814802-

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