File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Degeneration of corpus callosum and recovery of motor function after stroke: a multimodal magnetic resonance imaging study

TitleDegeneration of corpus callosum and recovery of motor function after stroke: a multimodal magnetic resonance imaging study
Authors
KeywordsDiffusion MRI
fMRI
Motor deficits
Corpus callosum
DTI
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
Citation
Human Brain Mapping, 2012, v. 33 n. 12, p. 2941-2956 How to Cite?
AbstractAnimal models of stroke demonstrated that white matter ischemia may cause both axonal damage and myelin degradation distant from the core lesion, thereby impacting on behavior and functional outcome after stroke. We here used parameters derived from diffusion magnetic resonance imaging (MRI) to investigate the effect of focal white matter ischemia on functional reorganization within the motor system. Patients (n = 18) suffering from hand motor deficits in the subacute or chronic stage after subcortical stroke and healthy controls (n = 12) were scanned with both diffusion MRI and functional MRI while performing a motor task with the left or right hand. A laterality index was employed on activated voxels to assess functional reorganization across hemispheres. Regression analyses revealed that diffusion MRI parameters of both the ipsilesional corticospinal tract (CST) and corpus callosum (CC) predicted increased activation of the unaffected hemisphere during movements of the stroke-affected hand. Changes in diffusion MRI parameters possibly reflecting axonal damage and/or destruction of myelin sheath correlated with a stronger bilateral recruitment of motor areas and poorer motor performance. Probabilistic fiber tracking analyses revealed that the region in the CC correlating with the fMRI laterality index and motor deficits connected to sensorimotor cortex, supplementary motor area, ventral premotor cortex, superior parietal lobule, and temporoparietal junction. The results suggest that degeneration of transcallosal fibers connecting higher order sensorimotor regions constitute a relevant factor influencing cortical reorganization and motor outcome after subcortical stroke. Hum Brain Mapp, 2012. (c) 2011 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/139703
ISSN
2015 Impact Factor: 4.962
2015 SCImago Journal Rankings: 3.165
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, LEen_US
dc.contributor.authorTittgemeyer, Men_US
dc.contributor.authorImperati, Den_US
dc.contributor.authorDiekhoff, Sen_US
dc.contributor.authorAmeli, Men_US
dc.contributor.authorFink, GRen_US
dc.contributor.authorGrefkes, Cen_US
dc.date.accessioned2011-09-23T05:54:31Z-
dc.date.available2011-09-23T05:54:31Z-
dc.date.issued2012en_US
dc.identifier.citationHuman Brain Mapping, 2012, v. 33 n. 12, p. 2941-2956en_US
dc.identifier.issn1065-9471-
dc.identifier.urihttp://hdl.handle.net/10722/139703-
dc.description.abstractAnimal models of stroke demonstrated that white matter ischemia may cause both axonal damage and myelin degradation distant from the core lesion, thereby impacting on behavior and functional outcome after stroke. We here used parameters derived from diffusion magnetic resonance imaging (MRI) to investigate the effect of focal white matter ischemia on functional reorganization within the motor system. Patients (n = 18) suffering from hand motor deficits in the subacute or chronic stage after subcortical stroke and healthy controls (n = 12) were scanned with both diffusion MRI and functional MRI while performing a motor task with the left or right hand. A laterality index was employed on activated voxels to assess functional reorganization across hemispheres. Regression analyses revealed that diffusion MRI parameters of both the ipsilesional corticospinal tract (CST) and corpus callosum (CC) predicted increased activation of the unaffected hemisphere during movements of the stroke-affected hand. Changes in diffusion MRI parameters possibly reflecting axonal damage and/or destruction of myelin sheath correlated with a stronger bilateral recruitment of motor areas and poorer motor performance. Probabilistic fiber tracking analyses revealed that the region in the CC correlating with the fMRI laterality index and motor deficits connected to sensorimotor cortex, supplementary motor area, ventral premotor cortex, superior parietal lobule, and temporoparietal junction. The results suggest that degeneration of transcallosal fibers connecting higher order sensorimotor regions constitute a relevant factor influencing cortical reorganization and motor outcome after subcortical stroke. Hum Brain Mapp, 2012. (c) 2011 Wiley Periodicals, Inc.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751-
dc.relation.ispartofHuman Brain Mappingen_US
dc.rightsHuman Brain Mapping. Copyright © John Wiley & Sons, Inc.-
dc.subjectDiffusion MRI-
dc.subjectfMRI-
dc.subjectMotor deficits-
dc.subjectCorpus callosum-
dc.subjectDTI-
dc.titleDegeneration of corpus callosum and recovery of motor function after stroke: a multimodal magnetic resonance imaging studyen_US
dc.typeArticleen_US
dc.identifier.emailWang, LE: lingwang@hku.hken_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hbm.21417-
dc.identifier.pmid22020952-
dc.identifier.scopuseid_2-s2.0-84868655576-
dc.identifier.hkuros194560en_US
dc.identifier.volume33-
dc.identifier.issue12en_US
dc.identifier.spage2941-
dc.identifier.epage2956-
dc.identifier.isiWOS:000310798800016-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats