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Article: Convergence of human brain mapping tools: neuronavigated TMS Parameters and fMRI activity in the hand motor area

TitleConvergence of human brain mapping tools: neuronavigated TMS Parameters and fMRI activity in the hand motor area
Authors
KeywordsBOLD signal
Motor threshold
DCM
Ipsilateral silent period
SMA
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751
Citation
Human Brain Mapping, 2012, v. 33 n. 5, p. 1107-1123 How to Cite?
AbstractFunctional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) are well-established tools for investigating the human motor system in-vivo. We here studied the relationship between movement-related fMRI signal changes in the primary motor cortex (M1) and electrophysiological properties of the hand motor area assessed with neuronavigated TMS in 17 healthy subjects. The voxel showing the highest task-related BOLD response in the left hand motor area during right hand movements was identified for each individual subject. This fMRI peak voxel in M1 served as spatial target for coil positioning during neuronavigated TMS. We performed correlation analyses between TMS parameters, BOLD signal estimates and effective connectivity parameters of M1 assessed with dynamic causal modeling (DCM). The results showed a negative correlation between the movement-related BOLD signal in left M1 and resting as well as active motor threshold (MT) obtained for left M1. The DCM analysis revealed that higher excitability of left M1 was associated with a stronger coupling between left supplementary motor area (SMA) and M1. Furthermore, BOLD activity in left M1 correlated with ipsilateral silent period (ISP), i.e. the stronger the task-related BOLD response in left M1, the higher interhemispheric inhibition effects targeting right M1. DCM analyses revealed a positive correlation between the coupling of left SMA with left M1 and the duration of ISP. The data show that TMS parameters assessed for the hand area of M1 do not only reflect the intrinsic properties at the stimulation site but also interactions with remote areas in the human motor system. Hum Brain Mapp, 2011. © 2011 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/139701
ISSN
2015 Impact Factor: 4.962
2015 SCImago Journal Rankings: 3.165
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSarfeld, ASen_US
dc.contributor.authorDiekhoff, Sen_US
dc.contributor.authorWang, LEen_US
dc.contributor.authorLiuzzi, Gen_US
dc.contributor.authorUludag, Ken_US
dc.contributor.authorEickhoff, SBen_US
dc.contributor.authorFink, GRen_US
dc.contributor.authorGrefkes, Cen_US
dc.date.accessioned2011-09-23T05:54:30Z-
dc.date.available2011-09-23T05:54:30Z-
dc.date.issued2012en_US
dc.identifier.citationHuman Brain Mapping, 2012, v. 33 n. 5, p. 1107-1123en_US
dc.identifier.issn1065-9471en_US
dc.identifier.urihttp://hdl.handle.net/10722/139701-
dc.description.abstractFunctional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) are well-established tools for investigating the human motor system in-vivo. We here studied the relationship between movement-related fMRI signal changes in the primary motor cortex (M1) and electrophysiological properties of the hand motor area assessed with neuronavigated TMS in 17 healthy subjects. The voxel showing the highest task-related BOLD response in the left hand motor area during right hand movements was identified for each individual subject. This fMRI peak voxel in M1 served as spatial target for coil positioning during neuronavigated TMS. We performed correlation analyses between TMS parameters, BOLD signal estimates and effective connectivity parameters of M1 assessed with dynamic causal modeling (DCM). The results showed a negative correlation between the movement-related BOLD signal in left M1 and resting as well as active motor threshold (MT) obtained for left M1. The DCM analysis revealed that higher excitability of left M1 was associated with a stronger coupling between left supplementary motor area (SMA) and M1. Furthermore, BOLD activity in left M1 correlated with ipsilateral silent period (ISP), i.e. the stronger the task-related BOLD response in left M1, the higher interhemispheric inhibition effects targeting right M1. DCM analyses revealed a positive correlation between the coupling of left SMA with left M1 and the duration of ISP. The data show that TMS parameters assessed for the hand area of M1 do not only reflect the intrinsic properties at the stimulation site but also interactions with remote areas in the human motor system. Hum Brain Mapp, 2011. © 2011 Wiley-Liss, Inc.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38751-
dc.relation.ispartofHuman Brain Mappingen_US
dc.rightsHuman Brain Mapping. Copyright © John Wiley & Sons, Inc.-
dc.subjectBOLD signal-
dc.subjectMotor threshold-
dc.subjectDCM-
dc.subjectIpsilateral silent period-
dc.subjectSMA-
dc.titleConvergence of human brain mapping tools: neuronavigated TMS Parameters and fMRI activity in the hand motor areaen_US
dc.typeArticleen_US
dc.identifier.emailWang, LE: lingwang@hku.hken_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hbm.21272-
dc.identifier.pmid21520346-
dc.identifier.scopuseid_2-s2.0-84859445851-
dc.identifier.hkuros194556en_US
dc.identifier.hkuros201745-
dc.identifier.volume33-
dc.identifier.issue5en_US
dc.identifier.spage1107-
dc.identifier.epage1123-
dc.identifier.eissn1097-0193-
dc.identifier.isiWOS:000302533100008-
dc.publisher.placeUnited States-
dc.identifier.citeulike10214436-

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