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Article: Chronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery

TitleChronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary artery
Authors
KeywordsHypoxia
Melatonin
Pulmonary artery
Issue Date2008
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal Of Cardiology, 2008, v. 126 n. 3, p. 340-345 How to Cite?
AbstractExposure of animals to chronic hypoxia induces pulmonary vascular remodeling leading to pulmonary hypertension. Melatonin, the principal hormone of the pineal gland, is known to have an inhibitory effect on rat vascular reactivity. This study examined the effect of chronic hypoxia on the influence of melatonin on the vasoreactivity of the pulmonary artery. The inhibitory effect of melatonin on the phenylephrine-induced constriction in normoxia-adapted rings (101.5 ± 4% versus 82.2 ± 4%) in the presence or absence of melatonin, respectively) was lost following chronic hypoxic treatment (100.2 ± 4% versus 102.2 ± 2%) and this effect was independent of the endothelium. Melatonin also significantly enhanced the relaxant response to acetylcholine of the pulmonary arterial rings from normoxic rats (34.76 ± 5.67% versus 53.82 ± 4.736%) in the absence or presence of melatonin, respectively). In contrast, melatonin had no significant effect (21.71 ± 1.37% versus 23.51 ± 6.891%) on the relaxant response to acetylcholine of the pulmonary arterial rings from chronic hypoxia-adapted rats. Pre-treatment with melatonin (10- 4 M) showed no significant effect on the vasorelaxation by the nitric oxide donor; sodium nitroprusside (10- 7-10- 5 M). The melatonin-induced changes were blocked by the melatonergic-receptor antagonist luzindole (2 × 10- 6 M). The results from our study confirm the presence of melatonergic receptors on the pulmonary trunk of rats and also suggest that the modulatory role of melatonin on the vasoreactivity of pulmonary trunk does not involve the nitric oxide pathway. Most importantly, our results show that development of pulmonary hypertension in rats is associated with the loss of the vasorelaxant influence of melatonin. © 2007 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/139669
ISSN
2015 Impact Factor: 4.638
2015 SCImago Journal Rankings: 1.513
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDas, Ren_HK
dc.contributor.authorBalonan, Len_HK
dc.contributor.authorBallard, HJen_HK
dc.contributor.authorHo, Sen_HK
dc.date.accessioned2011-09-23T05:53:14Z-
dc.date.available2011-09-23T05:53:14Z-
dc.date.issued2008en_HK
dc.identifier.citationInternational Journal Of Cardiology, 2008, v. 126 n. 3, p. 340-345en_HK
dc.identifier.issn0167-5273en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139669-
dc.description.abstractExposure of animals to chronic hypoxia induces pulmonary vascular remodeling leading to pulmonary hypertension. Melatonin, the principal hormone of the pineal gland, is known to have an inhibitory effect on rat vascular reactivity. This study examined the effect of chronic hypoxia on the influence of melatonin on the vasoreactivity of the pulmonary artery. The inhibitory effect of melatonin on the phenylephrine-induced constriction in normoxia-adapted rings (101.5 ± 4% versus 82.2 ± 4%) in the presence or absence of melatonin, respectively) was lost following chronic hypoxic treatment (100.2 ± 4% versus 102.2 ± 2%) and this effect was independent of the endothelium. Melatonin also significantly enhanced the relaxant response to acetylcholine of the pulmonary arterial rings from normoxic rats (34.76 ± 5.67% versus 53.82 ± 4.736%) in the absence or presence of melatonin, respectively). In contrast, melatonin had no significant effect (21.71 ± 1.37% versus 23.51 ± 6.891%) on the relaxant response to acetylcholine of the pulmonary arterial rings from chronic hypoxia-adapted rats. Pre-treatment with melatonin (10- 4 M) showed no significant effect on the vasorelaxation by the nitric oxide donor; sodium nitroprusside (10- 7-10- 5 M). The melatonin-induced changes were blocked by the melatonergic-receptor antagonist luzindole (2 × 10- 6 M). The results from our study confirm the presence of melatonergic receptors on the pulmonary trunk of rats and also suggest that the modulatory role of melatonin on the vasoreactivity of pulmonary trunk does not involve the nitric oxide pathway. Most importantly, our results show that development of pulmonary hypertension in rats is associated with the loss of the vasorelaxant influence of melatonin. © 2007 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_HK
dc.relation.ispartofInternational Journal of Cardiologyen_HK
dc.subjectHypoxiaen_HK
dc.subjectMelatoninen_HK
dc.subjectPulmonary arteryen_HK
dc.subject.meshAnoxia - complications-
dc.subject.meshHypertension, Pulmonary - drug therapy - physiopathology-
dc.subject.meshMelatonin - pharmacology-
dc.subject.meshPulmonary Artery - drug effects - physiology-
dc.subject.meshVasoconstriction - drug effects - physiology-
dc.titleChronic hypoxia inhibits the antihypertensive effect of melatonin on pulmonary arteryen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0167-5273&volume=126&issue=3&spage=340&epage=345&date=2008&atitle=Chronic+hypoxia+inhibits+the+antihypertensive+effect+of+melatonin+on+pulmonary+artery-
dc.identifier.emailBallard, HJ: ballard@hkucc.hku.hken_HK
dc.identifier.authorityBallard, HJ=rp00367en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijcard.2007.04.030en_HK
dc.identifier.pmid17590454-
dc.identifier.scopuseid_2-s2.0-43149093341en_HK
dc.identifier.hkuros196064en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43149093341&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume126en_HK
dc.identifier.issue3en_HK
dc.identifier.spage340en_HK
dc.identifier.epage345en_HK
dc.identifier.eissn1874-1754-
dc.identifier.isiWOS:000255927500007-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridDas, R=7202061890en_HK
dc.identifier.scopusauthoridBalonan, L=6504667340en_HK
dc.identifier.scopusauthoridBallard, HJ=7005286310en_HK
dc.identifier.scopusauthoridHo, S=7403716871en_HK

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