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Article: Circulating sex hormones modulate vascular contractions and acute response to 17β-estradiol in rat mesenteric arteries

TitleCirculating sex hormones modulate vascular contractions and acute response to 17β-estradiol in rat mesenteric arteries
Authors
Keywords17β-estradiol
Contraction
Estrogen receptor
Nongenomic vascular effects
Rat mesenteric arteries
Testosterone
Vascular smooth muscle
Issue Date2011
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHA
Citation
Pharmacology, 2011, v. 88 n. 1-2, p. 55-64 How to Cite?
AbstractAims: We investigated how modification of levels of the sex hormones 17β-estradiol and testosterone affects vascular contraction and nongenomic vascular effects of 17β-estradiol. Methods: Male and female rats were treated with vehicle, 17β-estradiol (25 μg/kg/day) or testosterone (1 mg/kg/day) for 14 consecutive days after sham gonadectomy or gonadectomy was performed. Isometric tensions were then measured from mesenteric arteries of each group of rats. Results: Contraction to phenylephrine was increased in mesenteric arteries from rats with or without gonadectomy treated with testosterone for 14 days compared to their intact controls. Contraction to phenylephrine was reduced in mesenteric arteries of rats with or without gonadectomy treated with 17β-estradiol for 14 days compared to their intact controls. Incubation of mesenteric arteries with 17β-estradiol (1 nmol/l) for 30 min reduced contraction to phenylephrine in mesenteric arteries of rats that were treated with testosterone for 14 days. This acute incubation of 17β-estradiol had no effect on arteries from rats that were treated with 17β-estradiol for 14 days. The acute effect of 17β-estradiol (1 nmol/l) is preserved in arteries without endothelium. Conclusion: Our results suggest that 14 days' testosterone treatment enhances while 14 days' 17β-estradiol treatment suppresses contraction as well as the nongenomic effects of 17β-estradiol in the vascular smooth muscles. Copyright © 2011 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/139595
ISSN
2015 Impact Factor: 1.533
2015 SCImago Journal Rankings: 0.645
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKeung, Wen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2011-09-23T05:52:21Z-
dc.date.available2011-09-23T05:52:21Z-
dc.date.issued2011en_HK
dc.identifier.citationPharmacology, 2011, v. 88 n. 1-2, p. 55-64en_HK
dc.identifier.issn0031-7012en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139595-
dc.description.abstractAims: We investigated how modification of levels of the sex hormones 17β-estradiol and testosterone affects vascular contraction and nongenomic vascular effects of 17β-estradiol. Methods: Male and female rats were treated with vehicle, 17β-estradiol (25 μg/kg/day) or testosterone (1 mg/kg/day) for 14 consecutive days after sham gonadectomy or gonadectomy was performed. Isometric tensions were then measured from mesenteric arteries of each group of rats. Results: Contraction to phenylephrine was increased in mesenteric arteries from rats with or without gonadectomy treated with testosterone for 14 days compared to their intact controls. Contraction to phenylephrine was reduced in mesenteric arteries of rats with or without gonadectomy treated with 17β-estradiol for 14 days compared to their intact controls. Incubation of mesenteric arteries with 17β-estradiol (1 nmol/l) for 30 min reduced contraction to phenylephrine in mesenteric arteries of rats that were treated with testosterone for 14 days. This acute incubation of 17β-estradiol had no effect on arteries from rats that were treated with 17β-estradiol for 14 days. The acute effect of 17β-estradiol (1 nmol/l) is preserved in arteries without endothelium. Conclusion: Our results suggest that 14 days' testosterone treatment enhances while 14 days' 17β-estradiol treatment suppresses contraction as well as the nongenomic effects of 17β-estradiol in the vascular smooth muscles. Copyright © 2011 S. Karger AG, Basel.en_HK
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/PHAen_HK
dc.relation.ispartofPharmacologyen_HK
dc.subject17β-estradiolen_HK
dc.subjectContractionen_HK
dc.subjectEstrogen receptoren_HK
dc.subjectNongenomic vascular effectsen_HK
dc.subjectRat mesenteric arteriesen_HK
dc.subjectTestosteroneen_HK
dc.subjectVascular smooth muscleen_HK
dc.titleCirculating sex hormones modulate vascular contractions and acute response to 17β-estradiol in rat mesenteric arteriesen_HK
dc.typeArticleen_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000329426en_HK
dc.identifier.pmid21791946-
dc.identifier.scopuseid_2-s2.0-79960689744en_HK
dc.identifier.hkuros192329en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960689744&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume88en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage55en_HK
dc.identifier.epage64en_HK
dc.identifier.isiWOS:000294219200008-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridKeung, W=19337708900en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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