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Article: Stem cell-based approaches for intervertebral disc regeneration
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TitleStem cell-based approaches for intervertebral disc regeneration
 
AuthorsHuang, S2
Tam, V2
Cheung, KMC2
Long, D3
Minmin, LV3
Wang, T2
Zhou, G3 1 2
 
KeywordsCell biology
Cell therapy
Intervertebral disc
MSCs
Niche
Stem cell
 
Issue Date2011
 
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cscrt/index.htm
 
CitationCurrent Stem Cell Research And Therapy, 2011, v. 6 n. 4, p. 317-326 [How to Cite?]
 
AbstractDegeneration of the intervertebral disc is an age-related progressive process considered to be the major cause of a series of spine disorders, such as low-back pain that affects the majority of adult population and causes a huge loss of time from work and medical expenses. Numerous regenerative approaches are being developed with the aim to halt or reverse degeneration, including intradiscal administration of nucleus pulposus cells and mesenchymal stem cells and anabolic growth factors. Each of the currently proposed approaches, however, has exhibited certain limitations or shortcomings, largely due to our limited understanding on the cell biology, turnover mechanisms of the intervertebral disc as well as the etiology of disc degeneration. Intervertebral disc, particularly the central nucleus pulposus, is the largest enclosed and avascular tissue in the body and owes a microenvironment under high mechanical and osmotic pressures, at severely hypoxia, and with very limited nutrient supply. In order to achieve an optimal outcome of new regenerative therapies in such a harsh circumstance, identifying and characterizing endogenous regenerative properties of normal and degenerate intervertebral disc, including stem/progenitor cells themselves and extracellular factors located within the stem cell niche, may provide effective insights into selecting the most suitable cell sources and improving or rebuilding the microenvironment favorable for endogenous or transplanted stem cells. © 2011 Bentham Science Publishers.
 
ISSN1574-888X
2012 Impact Factor: 2.963
2012 SCImago Journal Rankings: 0.904
 
ISI Accession Number IDWOS:000301640300002
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHuang, S
 
dc.contributor.authorTam, V
 
dc.contributor.authorCheung, KMC
 
dc.contributor.authorLong, D
 
dc.contributor.authorMinmin, LV
 
dc.contributor.authorWang, T
 
dc.contributor.authorZhou, G
 
dc.date.accessioned2011-09-23T05:51:39Z
 
dc.date.available2011-09-23T05:51:39Z
 
dc.date.issued2011
 
dc.description.abstractDegeneration of the intervertebral disc is an age-related progressive process considered to be the major cause of a series of spine disorders, such as low-back pain that affects the majority of adult population and causes a huge loss of time from work and medical expenses. Numerous regenerative approaches are being developed with the aim to halt or reverse degeneration, including intradiscal administration of nucleus pulposus cells and mesenchymal stem cells and anabolic growth factors. Each of the currently proposed approaches, however, has exhibited certain limitations or shortcomings, largely due to our limited understanding on the cell biology, turnover mechanisms of the intervertebral disc as well as the etiology of disc degeneration. Intervertebral disc, particularly the central nucleus pulposus, is the largest enclosed and avascular tissue in the body and owes a microenvironment under high mechanical and osmotic pressures, at severely hypoxia, and with very limited nutrient supply. In order to achieve an optimal outcome of new regenerative therapies in such a harsh circumstance, identifying and characterizing endogenous regenerative properties of normal and degenerate intervertebral disc, including stem/progenitor cells themselves and extracellular factors located within the stem cell niche, may provide effective insights into selecting the most suitable cell sources and improving or rebuilding the microenvironment favorable for endogenous or transplanted stem cells. © 2011 Bentham Science Publishers.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCurrent Stem Cell Research And Therapy, 2011, v. 6 n. 4, p. 317-326 [How to Cite?]
 
dc.identifier.epage326
 
dc.identifier.hkuros194072
 
dc.identifier.isiWOS:000301640300002
 
dc.identifier.issn1574-888X
2012 Impact Factor: 2.963
2012 SCImago Journal Rankings: 0.904
 
dc.identifier.issue4
 
dc.identifier.pmid21190533
 
dc.identifier.scopuseid_2-s2.0-80055111343
 
dc.identifier.spage317
 
dc.identifier.urihttp://hdl.handle.net/10722/139559
 
dc.identifier.volume6
 
dc.languageeng
 
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cscrt/index.htm
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofCurrent Stem Cell Research and Therapy
 
dc.relation.referencesReferences in Scopus
 
dc.subjectCell biology
 
dc.subjectCell therapy
 
dc.subjectIntervertebral disc
 
dc.subjectMSCs
 
dc.subjectNiche
 
dc.subjectStem cell
 
dc.titleStem cell-based approaches for intervertebral disc regeneration
 
dc.typeArticle
 
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<contributor.author>Long, D</contributor.author>
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Author Affiliations
  1. Shenzhen University
  2. The University of Hong Kong
  3. Sichuan University