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Article: Stem cell-based approaches for intervertebral disc regeneration

TitleStem cell-based approaches for intervertebral disc regeneration
Authors
KeywordsCell biology
Cell therapy
Intervertebral disc
MSCs
Niche
Stem cell
Issue Date2011
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cscrt/index.htm
Citation
Current Stem Cell Research And Therapy, 2011, v. 6 n. 4, p. 317-326 How to Cite?
AbstractDegeneration of the intervertebral disc is an age-related progressive process considered to be the major cause of a series of spine disorders, such as low-back pain that affects the majority of adult population and causes a huge loss of time from work and medical expenses. Numerous regenerative approaches are being developed with the aim to halt or reverse degeneration, including intradiscal administration of nucleus pulposus cells and mesenchymal stem cells and anabolic growth factors. Each of the currently proposed approaches, however, has exhibited certain limitations or shortcomings, largely due to our limited understanding on the cell biology, turnover mechanisms of the intervertebral disc as well as the etiology of disc degeneration. Intervertebral disc, particularly the central nucleus pulposus, is the largest enclosed and avascular tissue in the body and owes a microenvironment under high mechanical and osmotic pressures, at severely hypoxia, and with very limited nutrient supply. In order to achieve an optimal outcome of new regenerative therapies in such a harsh circumstance, identifying and characterizing endogenous regenerative properties of normal and degenerate intervertebral disc, including stem/progenitor cells themselves and extracellular factors located within the stem cell niche, may provide effective insights into selecting the most suitable cell sources and improving or rebuilding the microenvironment favorable for endogenous or transplanted stem cells. © 2011 Bentham Science Publishers.
Persistent Identifierhttp://hdl.handle.net/10722/139559
ISSN
2014 Impact Factor: 2.212
2014 SCImago Journal Rankings: 0.664
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, Sen_HK
dc.contributor.authorTam, Ven_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorLong, Den_HK
dc.contributor.authorMinmin, LVen_HK
dc.contributor.authorWang, Ten_HK
dc.contributor.authorZhou, Gen_HK
dc.date.accessioned2011-09-23T05:51:39Z-
dc.date.available2011-09-23T05:51:39Z-
dc.date.issued2011en_HK
dc.identifier.citationCurrent Stem Cell Research And Therapy, 2011, v. 6 n. 4, p. 317-326en_HK
dc.identifier.issn1574-888Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/139559-
dc.description.abstractDegeneration of the intervertebral disc is an age-related progressive process considered to be the major cause of a series of spine disorders, such as low-back pain that affects the majority of adult population and causes a huge loss of time from work and medical expenses. Numerous regenerative approaches are being developed with the aim to halt or reverse degeneration, including intradiscal administration of nucleus pulposus cells and mesenchymal stem cells and anabolic growth factors. Each of the currently proposed approaches, however, has exhibited certain limitations or shortcomings, largely due to our limited understanding on the cell biology, turnover mechanisms of the intervertebral disc as well as the etiology of disc degeneration. Intervertebral disc, particularly the central nucleus pulposus, is the largest enclosed and avascular tissue in the body and owes a microenvironment under high mechanical and osmotic pressures, at severely hypoxia, and with very limited nutrient supply. In order to achieve an optimal outcome of new regenerative therapies in such a harsh circumstance, identifying and characterizing endogenous regenerative properties of normal and degenerate intervertebral disc, including stem/progenitor cells themselves and extracellular factors located within the stem cell niche, may provide effective insights into selecting the most suitable cell sources and improving or rebuilding the microenvironment favorable for endogenous or transplanted stem cells. © 2011 Bentham Science Publishers.en_HK
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cscrt/index.htmen_HK
dc.relation.ispartofCurrent Stem Cell Research and Therapyen_HK
dc.subjectCell biologyen_HK
dc.subjectCell therapyen_HK
dc.subjectIntervertebral discen_HK
dc.subjectMSCsen_HK
dc.subjectNicheen_HK
dc.subjectStem cellen_HK
dc.titleStem cell-based approaches for intervertebral disc regenerationen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.emailZhou, G:wormoscz@gmail.comen_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityZhou, G=rp00527en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid21190533-
dc.identifier.scopuseid_2-s2.0-80055111343en_HK
dc.identifier.hkuros194072en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80055111343&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume6en_HK
dc.identifier.issue4en_HK
dc.identifier.spage317en_HK
dc.identifier.epage326en_HK
dc.identifier.isiWOS:000301640300002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHuang, S=53982847500en_HK
dc.identifier.scopusauthoridTam, V=35977084900en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridLong, D=7401958365en_HK
dc.identifier.scopusauthoridMinmin, LV=54397516300en_HK
dc.identifier.scopusauthoridWang, T=7405564863en_HK
dc.identifier.scopusauthoridZhou, G=23394245100en_HK

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