Article: Stem cell-based approaches for intervertebral disc regeneration

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TitleStem cell-based approaches for intervertebral disc regeneration
AuthorsHuang, S2
Tam, V2
Cheung, KMC2
Long, D3
Minmin, LV3
Wang, T2
Zhou, G1 2 3
KeywordsCell biology
Cell therapy
Intervertebral disc
MSCs
Niche
Stem cell
Issue Date2011
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cscrt/index.htm
CitationCurrent Stem Cell Research And Therapy, 2011, v. 6 n. 4, p. 317-326 [How to Cite?]
AbstractDegeneration of the intervertebral disc is an age-related progressive process considered to be the major cause of a series of spine disorders, such as low-back pain that affects the majority of adult population and causes a huge loss of time from work and medical expenses. Numerous regenerative approaches are being developed with the aim to halt or reverse degeneration, including intradiscal administration of nucleus pulposus cells and mesenchymal stem cells and anabolic growth factors. Each of the currently proposed approaches, however, has exhibited certain limitations or shortcomings, largely due to our limited understanding on the cell biology, turnover mechanisms of the intervertebral disc as well as the etiology of disc degeneration. Intervertebral disc, particularly the central nucleus pulposus, is the largest enclosed and avascular tissue in the body and owes a microenvironment under high mechanical and osmotic pressures, at severely hypoxia, and with very limited nutrient supply. In order to achieve an optimal outcome of new regenerative therapies in such a harsh circumstance, identifying and characterizing endogenous regenerative properties of normal and degenerate intervertebral disc, including stem/progenitor cells themselves and extracellular factors located within the stem cell niche, may provide effective insights into selecting the most suitable cell sources and improving or rebuilding the microenvironment favorable for endogenous or transplanted stem cells. © 2011 Bentham Science Publishers.
ISSN1574-888X
2011 SCImago Journal Rankings: 0.263
ISI Accession Number IDWOS:000301640300002
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorHuang, S
dc.contributor.authorTam, V
dc.contributor.authorCheung, KMC
dc.contributor.authorLong, D
dc.contributor.authorMinmin, LV
dc.contributor.authorWang, T
dc.contributor.authorZhou, G
dc.date.accessioned2011-09-23T05:51:39Z
dc.date.available2011-09-23T05:51:39Z
dc.date.issued2011
dc.description.abstractDegeneration of the intervertebral disc is an age-related progressive process considered to be the major cause of a series of spine disorders, such as low-back pain that affects the majority of adult population and causes a huge loss of time from work and medical expenses. Numerous regenerative approaches are being developed with the aim to halt or reverse degeneration, including intradiscal administration of nucleus pulposus cells and mesenchymal stem cells and anabolic growth factors. Each of the currently proposed approaches, however, has exhibited certain limitations or shortcomings, largely due to our limited understanding on the cell biology, turnover mechanisms of the intervertebral disc as well as the etiology of disc degeneration. Intervertebral disc, particularly the central nucleus pulposus, is the largest enclosed and avascular tissue in the body and owes a microenvironment under high mechanical and osmotic pressures, at severely hypoxia, and with very limited nutrient supply. In order to achieve an optimal outcome of new regenerative therapies in such a harsh circumstance, identifying and characterizing endogenous regenerative properties of normal and degenerate intervertebral disc, including stem/progenitor cells themselves and extracellular factors located within the stem cell niche, may provide effective insights into selecting the most suitable cell sources and improving or rebuilding the microenvironment favorable for endogenous or transplanted stem cells. © 2011 Bentham Science Publishers.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCurrent Stem Cell Research And Therapy, 2011, v. 6 n. 4, p. 317-326 [How to Cite?]
dc.identifier.epage326
dc.identifier.hkuros194072
dc.identifier.isiWOS:000301640300002
dc.identifier.issn1574-888X
2011 SCImago Journal Rankings: 0.263
dc.identifier.issue4
dc.identifier.pmid21190533
dc.identifier.scopuseid_2-s2.0-80055111343
dc.identifier.spage317
dc.identifier.urihttp://hdl.handle.net/10722/139559
dc.identifier.volume6
dc.languageeng
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cscrt/index.htm
dc.publisher.placeNetherlands
dc.relation.ispartofCurrent Stem Cell Research and Therapy
dc.relation.referencesReferences in Scopus
dc.subjectCell biology
dc.subjectCell therapy
dc.subjectIntervertebral disc
dc.subjectMSCs
dc.subjectNiche
dc.subjectStem cell
dc.titleStem cell-based approaches for intervertebral disc regeneration
dc.typeArticle
Author Affiliations
  1. Shenzhen University
  2. The University of Hong Kong
  3. Sichuan University