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Article: Modulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing

TitleModulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing
Authors
KeywordsCollagen organization
Healing
Silver nanoparticles
Tensile strength
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed
Citation
Nanomedicine: Nanotechnology, Biology, And Medicine, 2011, v. 7 n. 4, p. 497-504 How to Cite?
Abstract
Our previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. Immunohistochemical staining, quantitative assay and scanning electron microscopy (SEM) were used to detect and compare collagen deposition, and the morphology and distribution of collagen fibers. Our results showed that AgNPs improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. Based on our findings, we concluded that AgNPs were predominantly responsible for regulating deposition of collagen and their use resulted in excellent alignment in the wound healing process. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/139554
ISSN
2013 Impact Factor: 5.978
ISI Accession Number ID
Funding AgencyGrant Number
HKU200603159001
Funding Information:

The authors have no financial disclosures, and this work was supported by Seed Funding Programme for Basic Research, HKU (no. 200603159001).

References

 

DC FieldValueLanguage
dc.contributor.authorKwan, KHLen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorTo, MKTen_HK
dc.contributor.authorYeung, KWKen_HK
dc.contributor.authorHo, CMen_HK
dc.contributor.authorWong, KKYen_HK
dc.date.accessioned2011-09-23T05:51:36Z-
dc.date.available2011-09-23T05:51:36Z-
dc.date.issued2011en_HK
dc.identifier.citationNanomedicine: Nanotechnology, Biology, And Medicine, 2011, v. 7 n. 4, p. 497-504en_HK
dc.identifier.issn1549-9634en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139554-
dc.description.abstractOur previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. Immunohistochemical staining, quantitative assay and scanning electron microscopy (SEM) were used to detect and compare collagen deposition, and the morphology and distribution of collagen fibers. Our results showed that AgNPs improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. Based on our findings, we concluded that AgNPs were predominantly responsible for regulating deposition of collagen and their use resulted in excellent alignment in the wound healing process. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated. © 2011 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomeden_HK
dc.relation.ispartofNanomedicine: Nanotechnology, Biology, and Medicineen_HK
dc.subjectCollagen organizationen_HK
dc.subjectHealingen_HK
dc.subjectSilver nanoparticlesen_HK
dc.subjectTensile strengthen_HK
dc.titleModulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1549-9634&volume=7&issue=4&spage=497&epage=504&date=2011&atitle=Modulation+of+collagen+alignment+by+silver+nanoparticles+results+in+better+mechanical+properties+in+wound+healing-
dc.identifier.emailTo, MKT: mikektto@hku.hken_HK
dc.identifier.emailYeung, KWK: wkkyeung@hku.hken_HK
dc.identifier.emailHo, CM: rickyho@hkucc.hku.hken_HK
dc.identifier.emailWong, KKY: kkywong@hku.hken_HK
dc.identifier.authorityTo, MKT=rp00302en_HK
dc.identifier.authorityYeung, KWK=rp00309en_HK
dc.identifier.authorityHo, CM=rp00705en_HK
dc.identifier.authorityWong, KKY=rp01392en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.nano.2011.01.003en_HK
dc.identifier.pmid21272666en_HK
dc.identifier.scopuseid_2-s2.0-79960735142en_HK
dc.identifier.hkuros192188en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79960735142&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue4en_HK
dc.identifier.spage497en_HK
dc.identifier.epage504en_HK
dc.identifier.eissn1549-9642-
dc.identifier.isiWOS:000293218800015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwan, KHL=47861150900en_HK
dc.identifier.scopusauthoridLiu, X=36106291400en_HK
dc.identifier.scopusauthoridTo, MKT=35605045900en_HK
dc.identifier.scopusauthoridYeung, KWK=13309584700en_HK
dc.identifier.scopusauthoridHo, CM=12807243800en_HK
dc.identifier.scopusauthoridWong, KKY=24438686400en_HK

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