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Article: Modulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing
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TitleModulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing
 
AuthorsKwan, KHL1
Liu, X1
To, MKT1
Yeung, KWK1
Ho, CM2
Wong, KKY1
 
KeywordsCollagen organization
Healing
Silver nanoparticles
Tensile strength
 
Issue Date2011
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed
 
CitationNanomedicine: Nanotechnology, Biology, And Medicine, 2011, v. 7 n. 4, p. 497-504 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.nano.2011.01.003
 
AbstractOur previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. Immunohistochemical staining, quantitative assay and scanning electron microscopy (SEM) were used to detect and compare collagen deposition, and the morphology and distribution of collagen fibers. Our results showed that AgNPs improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. Based on our findings, we concluded that AgNPs were predominantly responsible for regulating deposition of collagen and their use resulted in excellent alignment in the wound healing process. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated. © 2011 Elsevier Inc.
 
ISSN1549-9634
2013 Impact Factor: 5.978
 
DOIhttp://dx.doi.org/10.1016/j.nano.2011.01.003
 
ISI Accession Number IDWOS:000293218800015
Funding AgencyGrant Number
HKU200603159001
Funding Information:

The authors have no financial disclosures, and this work was supported by Seed Funding Programme for Basic Research, HKU (no. 200603159001).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorKwan, KHL
 
dc.contributor.authorLiu, X
 
dc.contributor.authorTo, MKT
 
dc.contributor.authorYeung, KWK
 
dc.contributor.authorHo, CM
 
dc.contributor.authorWong, KKY
 
dc.date.accessioned2011-09-23T05:51:36Z
 
dc.date.available2011-09-23T05:51:36Z
 
dc.date.issued2011
 
dc.description.abstractOur previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. Immunohistochemical staining, quantitative assay and scanning electron microscopy (SEM) were used to detect and compare collagen deposition, and the morphology and distribution of collagen fibers. Our results showed that AgNPs improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. Based on our findings, we concluded that AgNPs were predominantly responsible for regulating deposition of collagen and their use resulted in excellent alignment in the wound healing process. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated. © 2011 Elsevier Inc.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationNanomedicine: Nanotechnology, Biology, And Medicine, 2011, v. 7 n. 4, p. 497-504 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.nano.2011.01.003
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.nano.2011.01.003
 
dc.identifier.eissn1549-9642
 
dc.identifier.epage504
 
dc.identifier.hkuros192188
 
dc.identifier.isiWOS:000293218800015
Funding AgencyGrant Number
HKU200603159001
Funding Information:

The authors have no financial disclosures, and this work was supported by Seed Funding Programme for Basic Research, HKU (no. 200603159001).

 
dc.identifier.issn1549-9634
2013 Impact Factor: 5.978
 
dc.identifier.issue4
 
dc.identifier.openurl
 
dc.identifier.pmid21272666
 
dc.identifier.scopuseid_2-s2.0-79960735142
 
dc.identifier.spage497
 
dc.identifier.urihttp://hdl.handle.net/10722/139554
 
dc.identifier.volume7
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNanomedicine: Nanotechnology, Biology, and Medicine
 
dc.relation.referencesReferences in Scopus
 
dc.subjectCollagen organization
 
dc.subjectHealing
 
dc.subjectSilver nanoparticles
 
dc.subjectTensile strength
 
dc.titleModulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong