Article: Modulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing

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TitleModulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing
AuthorsKwan, KHL1
Liu, X1
To, MKT1
Yeung, KWK1
Ho, CM2
Wong, KKY1
KeywordsCollagen organization
Healing
Silver nanoparticles
Tensile strength
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed
CitationNanomedicine: Nanotechnology, Biology, And Medicine, 2011, v. 7 n. 4, p. 497-504 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.nano.2011.01.003
AbstractOur previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. Immunohistochemical staining, quantitative assay and scanning electron microscopy (SEM) were used to detect and compare collagen deposition, and the morphology and distribution of collagen fibers. Our results showed that AgNPs improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. Based on our findings, we concluded that AgNPs were predominantly responsible for regulating deposition of collagen and their use resulted in excellent alignment in the wound healing process. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated. © 2011 Elsevier Inc.
ISSN1549-9634
2011 Impact Factor: 6.692
2011 SCImago Journal Rankings: 0.446
DOIhttp://dx.doi.org/10.1016/j.nano.2011.01.003
ReferencesReferences in Scopus
GrantsDoes silver nanoparticles play a role in hair regeneration and growth
DC Field
Value
dc.contributor.authorKwan, KHL
dc.contributor.authorLiu, X
dc.contributor.authorTo, MKT
dc.contributor.authorYeung, KWK
dc.contributor.authorHo, CM
dc.contributor.authorWong, KKY
dc.date.accessioned2011-09-23T05:51:36Z
dc.date.available2011-09-23T05:51:36Z
dc.date.issued2011
dc.description.abstractOur previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. Immunohistochemical staining, quantitative assay and scanning electron microscopy (SEM) were used to detect and compare collagen deposition, and the morphology and distribution of collagen fibers. Our results showed that AgNPs improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. Based on our findings, we concluded that AgNPs were predominantly responsible for regulating deposition of collagen and their use resulted in excellent alignment in the wound healing process. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated. © 2011 Elsevier Inc.
dc.description.grantDoes silver nanoparticles play a role in hair regeneration and growth
dc.description.grantcode82118
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationNanomedicine: Nanotechnology, Biology, And Medicine, 2011, v. 7 n. 4, p. 497-504 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.nano.2011.01.003
dc.identifier.doihttp://dx.doi.org/10.1016/j.nano.2011.01.003
dc.identifier.epage504
dc.identifier.hkuros192188
dc.identifier.isiWOS:000293218800015
Funding AgencyGrant Number
HKU200603159001
Funding Information:

The authors have no financial disclosures, and this work was supported by Seed Funding Programme for Basic Research, HKU (no. 200603159001).

dc.identifier.issn1549-9634
2011 Impact Factor: 6.692
2011 SCImago Journal Rankings: 0.446
dc.identifier.issue4
dc.identifier.openurl
dc.identifier.pmid21272666
dc.identifier.scopuseid_2-s2.0-79960735142
dc.identifier.spage497
dc.identifier.urihttp://hdl.handle.net/10722/139554
dc.identifier.volume7
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed
dc.publisher.placeUnited States
dc.relation.ispartofNanomedicine: Nanotechnology, Biology, and Medicine
dc.relation.referencesReferences in Scopus
dc.subjectCollagen organization
dc.subjectHealing
dc.subjectSilver nanoparticles
dc.subjectTensile strength
dc.titleModulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong