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- Publisher Website: 10.1016/j.nano.2011.01.003
- Scopus: eid_2-s2.0-79960735142
- PMID: 21272666
- WOS: WOS:000293218800015
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Article: Modulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing
Title | Modulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing | ||||
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Authors | |||||
Keywords | Collagen organization Healing Silver nanoparticles Tensile strength | ||||
Issue Date | 2011 | ||||
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed | ||||
Citation | Nanomedicine: Nanotechnology, Biology, And Medicine, 2011, v. 7 n. 4, p. 497-504 How to Cite? | ||||
Abstract | Our previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. Immunohistochemical staining, quantitative assay and scanning electron microscopy (SEM) were used to detect and compare collagen deposition, and the morphology and distribution of collagen fibers. Our results showed that AgNPs improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. Based on our findings, we concluded that AgNPs were predominantly responsible for regulating deposition of collagen and their use resulted in excellent alignment in the wound healing process. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated. © 2011 Elsevier Inc. | ||||
Persistent Identifier | http://hdl.handle.net/10722/139554 | ||||
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 0.863 | ||||
ISI Accession Number ID |
Funding Information: The authors have no financial disclosures, and this work was supported by Seed Funding Programme for Basic Research, HKU (no. 200603159001). | ||||
References | |||||
Grants |
DC Field | Value | Language |
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dc.contributor.author | Kwan, KHL | en_HK |
dc.contributor.author | Liu, X | en_HK |
dc.contributor.author | To, MKT | en_HK |
dc.contributor.author | Yeung, KWK | en_HK |
dc.contributor.author | Ho, CM | en_HK |
dc.contributor.author | Wong, KKY | en_HK |
dc.date.accessioned | 2011-09-23T05:51:36Z | - |
dc.date.available | 2011-09-23T05:51:36Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Nanomedicine: Nanotechnology, Biology, And Medicine, 2011, v. 7 n. 4, p. 497-504 | en_HK |
dc.identifier.issn | 1549-9634 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/139554 | - |
dc.description.abstract | Our previous study has revealed that silver nanoparticles (AgNPs) have potential to promote wound healing by accelerated re-epithelization and enhanced differentiation of fibroblasts. However, the effect of AgNPs on the functionality of repaired skin is unknown. The aim of this study was to explore the tensile properties of healed skin after treatment with AgNPs. Immunohistochemical staining, quantitative assay and scanning electron microscopy (SEM) were used to detect and compare collagen deposition, and the morphology and distribution of collagen fibers. Our results showed that AgNPs improved tensile properties and led to better fibril alignments in repaired skin, with a close resemblance to normal skin. Based on our findings, we concluded that AgNPs were predominantly responsible for regulating deposition of collagen and their use resulted in excellent alignment in the wound healing process. The exact signaling pathway by which AgNPs affect collagen regeneration is yet to be investigated. © 2011 Elsevier Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed | en_HK |
dc.relation.ispartof | Nanomedicine: Nanotechnology, Biology, and Medicine | en_HK |
dc.subject | Collagen organization | en_HK |
dc.subject | Healing | en_HK |
dc.subject | Silver nanoparticles | en_HK |
dc.subject | Tensile strength | en_HK |
dc.title | Modulation of collagen alignment by silver nanoparticles results in better mechanical properties in wound healing | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1549-9634&volume=7&issue=4&spage=497&epage=504&date=2011&atitle=Modulation+of+collagen+alignment+by+silver+nanoparticles+results+in+better+mechanical+properties+in+wound+healing | - |
dc.identifier.email | To, MKT: mikektto@hku.hk | en_HK |
dc.identifier.email | Yeung, KWK: wkkyeung@hku.hk | en_HK |
dc.identifier.email | Ho, CM: rickyho@hkucc.hku.hk | en_HK |
dc.identifier.email | Wong, KKY: kkywong@hku.hk | en_HK |
dc.identifier.authority | To, MKT=rp00302 | en_HK |
dc.identifier.authority | Yeung, KWK=rp00309 | en_HK |
dc.identifier.authority | Ho, CM=rp00705 | en_HK |
dc.identifier.authority | Wong, KKY=rp01392 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.nano.2011.01.003 | en_HK |
dc.identifier.pmid | 21272666 | - |
dc.identifier.scopus | eid_2-s2.0-79960735142 | en_HK |
dc.identifier.hkuros | 192188 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79960735142&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 7 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 497 | en_HK |
dc.identifier.epage | 504 | en_HK |
dc.identifier.eissn | 1549-9642 | - |
dc.identifier.isi | WOS:000293218800015 | - |
dc.publisher.place | United States | en_HK |
dc.relation.project | Does silver nanoparticles play a role in hair regeneration and growth | - |
dc.identifier.scopusauthorid | Kwan, KHL=47861150900 | en_HK |
dc.identifier.scopusauthorid | Liu, X=36106291400 | en_HK |
dc.identifier.scopusauthorid | To, MKT=35605045900 | en_HK |
dc.identifier.scopusauthorid | Yeung, KWK=13309584700 | en_HK |
dc.identifier.scopusauthorid | Ho, CM=12807243800 | en_HK |
dc.identifier.scopusauthorid | Wong, KKY=24438686400 | en_HK |
dc.identifier.issnl | 1549-9634 | - |