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Article: Relationship between osseointegration and superelastic biomechanics in porous NiTi scaffolds
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TitleRelationship between osseointegration and superelastic biomechanics in porous NiTi scaffolds
 
AuthorsLiu, X3 2 1
Wu, S2 3
Yeung, KWK1
Chan, YL1
Hu, T2
Xu, Z2 3
Liu, X2 4
Chung, JCY2
Cheung, KMC1
Chu, PK2
 
KeywordsBiomechanics
Osseointegration
Porous NiTi shape memory alloy
Scaffolds
Superelasticity
 
Issue Date2011
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
 
CitationBiomaterials, 2011, v. 32 n. 2, p. 330-338 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.biomaterials.2010.08.102
 
AbstractThe superelastic nature of bones requires matching biomechanical properties from the ideal artificial biomedical implants in order to provide smooth load transfer and foster the growth of new bone tissues. In this work, we determine the biomechanical characteristics of porous NiTi implants and investigate bone ingrowth under actual load-bearing conditions in vivo. In this systematic and comparative study, porous NiTi, porous Ti, dense NiTi, and dense Ti are implanted into 5 mm diameter holes in the distal part of the femur/tibia of rabbits for 15 weeks. The bone ingrowth and interfacial bonding strength are evaluated by histological analysis and push-out test. The porous NiTi materials bond very well to newly formed bone tissues and the highest average strength of 357 N and best ductility are achieved from the porous NiTi materials. The bonding curve obtained from the NiTi scaffold shows similar superelasticity as natural bones with a deflection of 0.30-0.85 mm thus shielding new bone tissues from large load stress. This is believed to be the reason why new bone tissues can penetrate deeply into the porous NiTi scaffold compared to the one made of porous Ti. Histological analysis reveals that new bone tissues adhere and grow well on the external surfaces as well as exposed areas on the inner pores of the NiTi scaffold. The in vitro study indicates that the surface chemical composition and topography of the porous structure leads to good cytocompatibility. Consequently, osteoblasts proliferate smoothly on the entire implant including the flat surface, embossed region, exposed area of the pores, and interconnected channels. In conjunction with the good cytocompatibility, the superelastic biomechanical properties of the porous NiTi scaffold bodes well for fast formation and ingrowth of new bones, and porous NiTi scaffolds are thus suitable for clinical applications under load-bearing conditions. © 2010 Elsevier Ltd.
 
ISSN0142-9612
2013 Impact Factor: 8.312
 
DOIhttp://dx.doi.org/10.1016/j.biomaterials.2010.08.102
 
ISI Accession Number IDWOS:000285401500002
Funding AgencyGrant Number
City University of Hong Kong7008009
9678021
Hong Kong Research Grant Council (RGC)123708
112307
National Natural Science Foundation of China50901032
Ministry of Education Specialized Research Foundation20094208120003
Hubei Provincial Natural Science Foundation2009CBD359
Funding Information:

This work is jointly supported by City University of Hong Kong Strategic Research Grant (SRG) No 7008009 City University of Hong Kong Matching Research Grants Nos 9678021 and 9678021 Hong Kong Research Grant Council (RGC) General Research Funds (GRF) Nos 123708 and 112307 National Natural Science Foundation of China No 50901032 Ministry of Education Specialized Research Foundation for Doctoral Program of Universities No 20094208120003 and Hubei Provincial Natural Science Foundation No 2009CBD359 The first author X M Liu thanks Mr Steven Chan (Department of Orthopaedics and Traumatology The University of Hong Kong) for providing assistance to the biomechanics tests

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLiu, X
 
dc.contributor.authorWu, S
 
dc.contributor.authorYeung, KWK
 
dc.contributor.authorChan, YL
 
dc.contributor.authorHu, T
 
dc.contributor.authorXu, Z
 
dc.contributor.authorLiu, X
 
dc.contributor.authorChung, JCY
 
dc.contributor.authorCheung, KMC
 
dc.contributor.authorChu, PK
 
dc.date.accessioned2011-09-23T05:51:33Z
 
dc.date.available2011-09-23T05:51:33Z
 
dc.date.issued2011
 
dc.description.abstractThe superelastic nature of bones requires matching biomechanical properties from the ideal artificial biomedical implants in order to provide smooth load transfer and foster the growth of new bone tissues. In this work, we determine the biomechanical characteristics of porous NiTi implants and investigate bone ingrowth under actual load-bearing conditions in vivo. In this systematic and comparative study, porous NiTi, porous Ti, dense NiTi, and dense Ti are implanted into 5 mm diameter holes in the distal part of the femur/tibia of rabbits for 15 weeks. The bone ingrowth and interfacial bonding strength are evaluated by histological analysis and push-out test. The porous NiTi materials bond very well to newly formed bone tissues and the highest average strength of 357 N and best ductility are achieved from the porous NiTi materials. The bonding curve obtained from the NiTi scaffold shows similar superelasticity as natural bones with a deflection of 0.30-0.85 mm thus shielding new bone tissues from large load stress. This is believed to be the reason why new bone tissues can penetrate deeply into the porous NiTi scaffold compared to the one made of porous Ti. Histological analysis reveals that new bone tissues adhere and grow well on the external surfaces as well as exposed areas on the inner pores of the NiTi scaffold. The in vitro study indicates that the surface chemical composition and topography of the porous structure leads to good cytocompatibility. Consequently, osteoblasts proliferate smoothly on the entire implant including the flat surface, embossed region, exposed area of the pores, and interconnected channels. In conjunction with the good cytocompatibility, the superelastic biomechanical properties of the porous NiTi scaffold bodes well for fast formation and ingrowth of new bones, and porous NiTi scaffolds are thus suitable for clinical applications under load-bearing conditions. © 2010 Elsevier Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationBiomaterials, 2011, v. 32 n. 2, p. 330-338 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.biomaterials.2010.08.102
 
dc.identifier.citeulike7923755
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.biomaterials.2010.08.102
 
dc.identifier.epage338
 
dc.identifier.hkuros192181
 
dc.identifier.isiWOS:000285401500002
Funding AgencyGrant Number
City University of Hong Kong7008009
9678021
Hong Kong Research Grant Council (RGC)123708
112307
National Natural Science Foundation of China50901032
Ministry of Education Specialized Research Foundation20094208120003
Hubei Provincial Natural Science Foundation2009CBD359
Funding Information:

This work is jointly supported by City University of Hong Kong Strategic Research Grant (SRG) No 7008009 City University of Hong Kong Matching Research Grants Nos 9678021 and 9678021 Hong Kong Research Grant Council (RGC) General Research Funds (GRF) Nos 123708 and 112307 National Natural Science Foundation of China No 50901032 Ministry of Education Specialized Research Foundation for Doctoral Program of Universities No 20094208120003 and Hubei Provincial Natural Science Foundation No 2009CBD359 The first author X M Liu thanks Mr Steven Chan (Department of Orthopaedics and Traumatology The University of Hong Kong) for providing assistance to the biomechanics tests

 
dc.identifier.issn0142-9612
2013 Impact Factor: 8.312
 
dc.identifier.issue2
 
dc.identifier.pmid20869110
 
dc.identifier.scopuseid_2-s2.0-78449238088
 
dc.identifier.spage330
 
dc.identifier.urihttp://hdl.handle.net/10722/139548
 
dc.identifier.volume32
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofBiomaterials
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshBiomechanics
 
dc.subject.meshNickel - chemistry
 
dc.subject.meshOsseointegration - physiology
 
dc.subject.meshTissue Scaffolds - chemistry
 
dc.subject.meshTitanium - chemistry
 
dc.subjectBiomechanics
 
dc.subjectOsseointegration
 
dc.subjectPorous NiTi shape memory alloy
 
dc.subjectScaffolds
 
dc.subjectSuperelasticity
 
dc.titleRelationship between osseointegration and superelastic biomechanics in porous NiTi scaffolds
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. City University of Hong Kong
  3. Hubei University
  4. Shanghai Institute of Ceramics Chinese Academy of Sciences