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Article: Relationship between osseointegration and superelastic biomechanics in porous NiTi scaffolds

TitleRelationship between osseointegration and superelastic biomechanics in porous NiTi scaffolds
Authors
KeywordsBiomechanics
Osseointegration
Porous NiTi shape memory alloy
Scaffolds
Superelasticity
Issue Date2011
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2011, v. 32 n. 2, p. 330-338 How to Cite?
Abstract
The superelastic nature of bones requires matching biomechanical properties from the ideal artificial biomedical implants in order to provide smooth load transfer and foster the growth of new bone tissues. In this work, we determine the biomechanical characteristics of porous NiTi implants and investigate bone ingrowth under actual load-bearing conditions in vivo. In this systematic and comparative study, porous NiTi, porous Ti, dense NiTi, and dense Ti are implanted into 5 mm diameter holes in the distal part of the femur/tibia of rabbits for 15 weeks. The bone ingrowth and interfacial bonding strength are evaluated by histological analysis and push-out test. The porous NiTi materials bond very well to newly formed bone tissues and the highest average strength of 357 N and best ductility are achieved from the porous NiTi materials. The bonding curve obtained from the NiTi scaffold shows similar superelasticity as natural bones with a deflection of 0.30-0.85 mm thus shielding new bone tissues from large load stress. This is believed to be the reason why new bone tissues can penetrate deeply into the porous NiTi scaffold compared to the one made of porous Ti. Histological analysis reveals that new bone tissues adhere and grow well on the external surfaces as well as exposed areas on the inner pores of the NiTi scaffold. The in vitro study indicates that the surface chemical composition and topography of the porous structure leads to good cytocompatibility. Consequently, osteoblasts proliferate smoothly on the entire implant including the flat surface, embossed region, exposed area of the pores, and interconnected channels. In conjunction with the good cytocompatibility, the superelastic biomechanical properties of the porous NiTi scaffold bodes well for fast formation and ingrowth of new bones, and porous NiTi scaffolds are thus suitable for clinical applications under load-bearing conditions. © 2010 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/139548
ISSN
2013 Impact Factor: 8.312
ISI Accession Number ID
Funding AgencyGrant Number
City University of Hong Kong7008009
9678021
Hong Kong Research Grant Council (RGC)123708
112307
National Natural Science Foundation of China50901032
Ministry of Education Specialized Research Foundation20094208120003
Hubei Provincial Natural Science Foundation2009CBD359
Funding Information:

This work is jointly supported by City University of Hong Kong Strategic Research Grant (SRG) No 7008009 City University of Hong Kong Matching Research Grants Nos 9678021 and 9678021 Hong Kong Research Grant Council (RGC) General Research Funds (GRF) Nos 123708 and 112307 National Natural Science Foundation of China No 50901032 Ministry of Education Specialized Research Foundation for Doctoral Program of Universities No 20094208120003 and Hubei Provincial Natural Science Foundation No 2009CBD359 The first author X M Liu thanks Mr Steven Chan (Department of Orthopaedics and Traumatology The University of Hong Kong) for providing assistance to the biomechanics tests

References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorWu, Sen_HK
dc.contributor.authorYeung, KWKen_HK
dc.contributor.authorChan, YLen_HK
dc.contributor.authorHu, Ten_HK
dc.contributor.authorXu, Zen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorChung, JCYen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorChu, PKen_HK
dc.date.accessioned2011-09-23T05:51:33Z-
dc.date.available2011-09-23T05:51:33Z-
dc.date.issued2011en_HK
dc.identifier.citationBiomaterials, 2011, v. 32 n. 2, p. 330-338en_HK
dc.identifier.issn0142-9612en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139548-
dc.description.abstractThe superelastic nature of bones requires matching biomechanical properties from the ideal artificial biomedical implants in order to provide smooth load transfer and foster the growth of new bone tissues. In this work, we determine the biomechanical characteristics of porous NiTi implants and investigate bone ingrowth under actual load-bearing conditions in vivo. In this systematic and comparative study, porous NiTi, porous Ti, dense NiTi, and dense Ti are implanted into 5 mm diameter holes in the distal part of the femur/tibia of rabbits for 15 weeks. The bone ingrowth and interfacial bonding strength are evaluated by histological analysis and push-out test. The porous NiTi materials bond very well to newly formed bone tissues and the highest average strength of 357 N and best ductility are achieved from the porous NiTi materials. The bonding curve obtained from the NiTi scaffold shows similar superelasticity as natural bones with a deflection of 0.30-0.85 mm thus shielding new bone tissues from large load stress. This is believed to be the reason why new bone tissues can penetrate deeply into the porous NiTi scaffold compared to the one made of porous Ti. Histological analysis reveals that new bone tissues adhere and grow well on the external surfaces as well as exposed areas on the inner pores of the NiTi scaffold. The in vitro study indicates that the surface chemical composition and topography of the porous structure leads to good cytocompatibility. Consequently, osteoblasts proliferate smoothly on the entire implant including the flat surface, embossed region, exposed area of the pores, and interconnected channels. In conjunction with the good cytocompatibility, the superelastic biomechanical properties of the porous NiTi scaffold bodes well for fast formation and ingrowth of new bones, and porous NiTi scaffolds are thus suitable for clinical applications under load-bearing conditions. © 2010 Elsevier Ltd.en_HK
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterialsen_HK
dc.relation.ispartofBiomaterialsen_HK
dc.subjectBiomechanicsen_HK
dc.subjectOsseointegrationen_HK
dc.subjectPorous NiTi shape memory alloyen_HK
dc.subjectScaffoldsen_HK
dc.subjectSuperelasticityen_HK
dc.subject.meshBiomechanics-
dc.subject.meshNickel - chemistry-
dc.subject.meshOsseointegration - physiology-
dc.subject.meshTissue Scaffolds - chemistry-
dc.subject.meshTitanium - chemistry-
dc.titleRelationship between osseointegration and superelastic biomechanics in porous NiTi scaffoldsen_HK
dc.typeArticleen_HK
dc.identifier.emailYeung, KWK:wkkyeung@hkucc.hku.hken_HK
dc.identifier.emailCheung, KMC:cheungmc@hku.hken_HK
dc.identifier.authorityYeung, KWK=rp00309en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biomaterials.2010.08.102en_HK
dc.identifier.pmid20869110en_HK
dc.identifier.scopuseid_2-s2.0-78449238088en_HK
dc.identifier.hkuros192181en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78449238088&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue2en_HK
dc.identifier.spage330en_HK
dc.identifier.epage338en_HK
dc.identifier.isiWOS:000285401500002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLiu, X=36092970100en_HK
dc.identifier.scopusauthoridWu, S=15125218800en_HK
dc.identifier.scopusauthoridYeung, KWK=13309584700en_HK
dc.identifier.scopusauthoridChan, YL=8250546500en_HK
dc.identifier.scopusauthoridHu, T=25948400300en_HK
dc.identifier.scopusauthoridXu, Z=36667971600en_HK
dc.identifier.scopusauthoridLiu, X=35237960300en_HK
dc.identifier.scopusauthoridChung, JCY=7404002978en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridChu, PK=36040705700en_HK
dc.identifier.citeulike7923755-

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