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Article: Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene
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TitleMolecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene
 
AuthorsTo, KKW1 3
Cheng, VCC3
Chan, JFW3
Wong, ACY3
Chau, S2
Tsang, FHF3
Curreem, SOT1
Lau, SKP1 3
Yuen, KY1 3
Woo, PCY1 3
 
KeywordsCatalase
Adolescent
Antibiotic sensitivity
Antibody titer
Bacterial endocarditis
 
Issue Date2011
 
PublisherAmerican Society for Microbiology.
 
CitationJournal Of Clinical Microbiology, 2011, v. 49 n. 9, p. 3398-3402 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JCM.00849-11
 
AbstractWe report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
 
ISSN0095-1137
2012 Impact Factor: 4.068
2012 SCImago Journal Rankings: 1.785
 
DOIhttp://dx.doi.org/10.1128/JCM.00849-11
 
PubMed Central IDPMC3165592
 
ISI Accession Number IDWOS:000294416000057
Funding AgencyGrant Number
University Development Fund
Committee on Research and Conference Grants, The University of Hong Kong
Funding Information:

This work is partly supported by the University Development Fund and the Committee on Research and Conference Grants, The University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTo, KKW
 
dc.contributor.authorCheng, VCC
 
dc.contributor.authorChan, JFW
 
dc.contributor.authorWong, ACY
 
dc.contributor.authorChau, S
 
dc.contributor.authorTsang, FHF
 
dc.contributor.authorCurreem, SOT
 
dc.contributor.authorLau, SKP
 
dc.contributor.authorYuen, KY
 
dc.contributor.authorWoo, PCY
 
dc.date.accessioned2011-09-23T05:50:53Z
 
dc.date.available2011-09-23T05:50:53Z
 
dc.date.issued2011
 
dc.description.abstractWe report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationJournal Of Clinical Microbiology, 2011, v. 49 n. 9, p. 3398-3402 [How to Cite?]
DOI: http://dx.doi.org/10.1128/JCM.00849-11
 
dc.identifier.doihttp://dx.doi.org/10.1128/JCM.00849-11
 
dc.identifier.epage3402
 
dc.identifier.hkuros192140
 
dc.identifier.hkuros190821
 
dc.identifier.isiWOS:000294416000057
Funding AgencyGrant Number
University Development Fund
Committee on Research and Conference Grants, The University of Hong Kong
Funding Information:

This work is partly supported by the University Development Fund and the Committee on Research and Conference Grants, The University of Hong Kong.

 
dc.identifier.issn0095-1137
2012 Impact Factor: 4.068
2012 SCImago Journal Rankings: 1.785
 
dc.identifier.issue9
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC3165592
 
dc.identifier.pmid21715584
 
dc.identifier.scopuseid_2-s2.0-80052202334
 
dc.identifier.spage3398
 
dc.identifier.urihttp://hdl.handle.net/10722/139510
 
dc.identifier.volume49
 
dc.languageeng
 
dc.publisherAmerican Society for Microbiology.
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Clinical Microbiology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsJournal of Clinical Microbiology. Copyright © American Society for Microbiology.
 
dc.subjectCatalase
 
dc.subjectAdolescent
 
dc.subjectAntibiotic sensitivity
 
dc.subjectAntibody titer
 
dc.subjectBacterial endocarditis
 
dc.titleMolecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. United Christian Hospital Hong Kong
  3. Queen Mary Hospital Hong Kong