Article: Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene
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- Publisher Website: 10.1128/JCM.00849-11
- Scopus: eid_2-s2.0-80052202334
- PMID: 21715584
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| Title | Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene | ||||||
|---|---|---|---|---|---|---|---|
| Authors | To, KKW Cheng, VCC Chan, JFW Wong, ACY Chau, S Tsang, FHF Curreem, SOT Lau, SKP Yuen, KY Woo, PCY | ||||||
| Keywords | Catalase Adolescent Antibiotic sensitivity Antibody titer Bacterial endocarditis | ||||||
| Issue Date | 2011 | ||||||
| Publisher | American Society for Microbiology. | ||||||
| Citation | Journal Of Clinical Microbiology, 2011, v. 49 n. 9, p. 3398-3402 [How to Cite?] DOI: http://dx.doi.org/10.1128/JCM.00849-11 | ||||||
| Abstract | We report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis. Copyright © 2011, American Society for Microbiology. All Rights Reserved. | ||||||
| ISSN | 0095-1137 2011 Impact Factor: 4.153 2011 SCImago Journal Rankings: 0.397 | ||||||
| DOI | http://dx.doi.org/10.1128/JCM.00849-11 | ||||||
| ISI Accession Number ID | WOS:000294416000057
Funding Information: This work is partly supported by the University Development Fund and the Committee on Research and Conference Grants, The University of Hong Kong. | ||||||
| PubMed Central ID | PMC3165592 | ||||||
| References | References in Scopus |
| dc.contributor.author | To, KKW | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Cheng, VCC | ||||||
| dc.contributor.author | Chan, JFW | ||||||
| dc.contributor.author | Wong, ACY | ||||||
| dc.contributor.author | Chau, S | ||||||
| dc.contributor.author | Tsang, FHF | ||||||
| dc.contributor.author | Curreem, SOT | ||||||
| dc.contributor.author | Lau, SKP | ||||||
| dc.contributor.author | Yuen, KY | ||||||
| dc.contributor.author | Woo, PCY | ||||||
| dc.date.accessioned | 2011-09-23T05:50:53Z | ||||||
| dc.date.available | 2011-09-23T05:50:53Z | ||||||
| dc.date.issued | 2011 | ||||||
| dc.description.abstract | We report a case of endocarditis and pericarditis caused by catalase-negative Staphylococcus aureus. Molecular characterization revealed a novel nonsense mutation in the katA gene, leading to a loss of 238 amino acids (47% of the wild-type catalase protein), including the heme-binding site, NADPH-binding region, and Tyr-337, essential for catalysis. Copyright © 2011, American Society for Microbiology. All Rights Reserved. | ||||||
| dc.description.nature | link_to_OA_fulltext | ||||||
| dc.identifier.citation | Journal Of Clinical Microbiology, 2011, v. 49 n. 9, p. 3398-3402 [How to Cite?] DOI: http://dx.doi.org/10.1128/JCM.00849-11 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1128/JCM.00849-11 | ||||||
| dc.identifier.epage | 3402 | ||||||
| dc.identifier.hkuros | 192140 | ||||||
| dc.identifier.hkuros | 190821 | ||||||
| dc.identifier.isi | WOS:000294416000057
Funding Information: This work is partly supported by the University Development Fund and the Committee on Research and Conference Grants, The University of Hong Kong. | ||||||
| dc.identifier.issn | 0095-1137 2011 Impact Factor: 4.153 2011 SCImago Journal Rankings: 0.397 | ||||||
| dc.identifier.issue | 9 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmcid | PMC3165592 | ||||||
| dc.identifier.pmid | 21715584 | ||||||
| dc.identifier.scopus | eid_2-s2.0-80052202334 | ||||||
| dc.identifier.spage | 3398 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/139510 | ||||||
| dc.identifier.volume | 49 | ||||||
| dc.language | eng | ||||||
| dc.publisher | American Society for Microbiology. | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Journal of Clinical Microbiology | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | Journal of Clinical Microbiology. Copyright © American Society for Microbiology. | ||||||
| dc.subject | Catalase | ||||||
| dc.subject | Adolescent | ||||||
| dc.subject | Antibiotic sensitivity | ||||||
| dc.subject | Antibody titer | ||||||
| dc.subject | Bacterial endocarditis | ||||||
| dc.title | Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus strain collected from a patient with mitral valve endocarditis and pericarditis revealed a novel nonsense mutation in the katA gene | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- United Christian Hospital Hong Kong
- Queen Mary Hospital Hong Kong