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Article: Early detection of central airway lung cancer in smokers with silicosis
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TitleEarly detection of central airway lung cancer in smokers with silicosis
 
AuthorsLo, AIL1 2
Huang, Y2 3
Lam, SY
Cheung, AHK2
Au, R
Leung, CC
Lam, WK2
Ip, MSM2
ChanYeung, M2
Lam, B2
 
KeywordsAutofluorescence bronchoscopy
Early detection
Lung cancer
Silicosis
 
Issue Date2011
 
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
 
CitationInternational Journal Of Tuberculosis And Lung Disease, 2011, v. 15 n. 4, p. 523-527 [How to Cite?]
DOI: http://dx.doi.org/10.5588/ijtld.10.0461
 
AbstractBACKGROUND: Smokers with silicosis are at increased risk of lung cancer. OBJECTIVE: To evaluate the feasibility of using auto-fluorescence bronchoscopy after sputum examination for early detection of large airway lung cancer and factors associated with the presence of cancerous and prec ancerous lesions among smokers with silicosis. METHODS: Subjects at the pneumoconiosis clinic were recruited if they fulfilled the following criteria: 1) age ≥40 years, 2) smoking history of ≥20 pack-years and 3) confirmed diagnosis of silicosis. Sputum specimens were collected for cytology/cytometry examination and autofluorescence bronchoscopy was performed in subjects with an abnormal sputum result. RESULTS: A total of 48 subjects were recruited during the study period. The mean age and smoking history were respectively 63 ± 10 years and 51 ± 30 pack-years. Intraepithelial lung cancers and pre-neoplastic lesions (squamous metaplasia or above) were detected in respectively 2 (4.2%) and 14 (29.2%) subjects. The proportions of current smokers (75.0% vs. 40.6%, P = 0.03) and asbestos exposure (37.5% vs. 9.4%, P = 0.04) were significantly higher in subjects with the above lesions compared with those without. CONCLUSIONS: Sputum examination followed by auto-fluorescence bronchoscopy may be a useful way of identifying cancerous/pre-cancerous lesions among silicotic smokers. Current smoking and asbestos exposure were associated with these lesions. © 2011 The Union.
 
ISSN1027-3719
2012 Impact Factor: 2.61
2012 SCImago Journal Rankings: 1.340
 
DOIhttp://dx.doi.org/10.5588/ijtld.10.0461
 
ISI Accession Number IDWOS:000288882300018
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong
Funding Information:

The authors thank Shun Tak District Min Yuen Tong for financial support for this study.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLo, AIL
 
dc.contributor.authorHuang, Y
 
dc.contributor.authorLam, SY
 
dc.contributor.authorCheung, AHK
 
dc.contributor.authorAu, R
 
dc.contributor.authorLeung, CC
 
dc.contributor.authorLam, WK
 
dc.contributor.authorIp, MSM
 
dc.contributor.authorChanYeung, M
 
dc.contributor.authorLam, B
 
dc.date.accessioned2011-09-23T05:50:46Z
 
dc.date.available2011-09-23T05:50:46Z
 
dc.date.issued2011
 
dc.description.abstractBACKGROUND: Smokers with silicosis are at increased risk of lung cancer. OBJECTIVE: To evaluate the feasibility of using auto-fluorescence bronchoscopy after sputum examination for early detection of large airway lung cancer and factors associated with the presence of cancerous and prec ancerous lesions among smokers with silicosis. METHODS: Subjects at the pneumoconiosis clinic were recruited if they fulfilled the following criteria: 1) age ≥40 years, 2) smoking history of ≥20 pack-years and 3) confirmed diagnosis of silicosis. Sputum specimens were collected for cytology/cytometry examination and autofluorescence bronchoscopy was performed in subjects with an abnormal sputum result. RESULTS: A total of 48 subjects were recruited during the study period. The mean age and smoking history were respectively 63 ± 10 years and 51 ± 30 pack-years. Intraepithelial lung cancers and pre-neoplastic lesions (squamous metaplasia or above) were detected in respectively 2 (4.2%) and 14 (29.2%) subjects. The proportions of current smokers (75.0% vs. 40.6%, P = 0.03) and asbestos exposure (37.5% vs. 9.4%, P = 0.04) were significantly higher in subjects with the above lesions compared with those without. CONCLUSIONS: Sputum examination followed by auto-fluorescence bronchoscopy may be a useful way of identifying cancerous/pre-cancerous lesions among silicotic smokers. Current smoking and asbestos exposure were associated with these lesions. © 2011 The Union.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2011, v. 15 n. 4, p. 523-527 [How to Cite?]
DOI: http://dx.doi.org/10.5588/ijtld.10.0461
 
dc.identifier.citeulike9000481
 
dc.identifier.doihttp://dx.doi.org/10.5588/ijtld.10.0461
 
dc.identifier.epage527
 
dc.identifier.hkuros196578
 
dc.identifier.isiWOS:000288882300018
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong
Funding Information:

The authors thank Shun Tak District Min Yuen Tong for financial support for this study.

 
dc.identifier.issn1027-3719
2012 Impact Factor: 2.61
2012 SCImago Journal Rankings: 1.340
 
dc.identifier.issue4
 
dc.identifier.pmid21396213
 
dc.identifier.scopuseid_2-s2.0-79952798181
 
dc.identifier.spage523
 
dc.identifier.urihttp://hdl.handle.net/10722/139508
 
dc.identifier.volume15
 
dc.languageeng
 
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
 
dc.publisher.placeFrance
 
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Disease
 
dc.relation.referencesReferences in Scopus
 
dc.rightsInternational Journal of Tuberculosis and Lung Disease. Copyright © International Union against Tuberculosis and Lung Disease.
 
dc.subject.meshAsbestos - toxicity
 
dc.subject.meshBronchoscopy - methods
 
dc.subject.meshLung Neoplasms - diagnosis - etiology - pathology
 
dc.subject.meshSilicosis - complications
 
dc.subject.meshSmoking - adverse effects
 
dc.subjectAutofluorescence bronchoscopy
 
dc.subjectEarly detection
 
dc.subjectLung cancer
 
dc.subjectSilicosis
 
dc.titleEarly detection of central airway lung cancer in smokers with silicosis
 
dc.typeArticle
 
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<contributor.author>Huang, Y</contributor.author>
<contributor.author>Lam, SY</contributor.author>
<contributor.author>Cheung, AHK</contributor.author>
<contributor.author>Au, R</contributor.author>
<contributor.author>Leung, CC</contributor.author>
<contributor.author>Lam, WK</contributor.author>
<contributor.author>Ip, MSM</contributor.author>
<contributor.author>ChanYeung, M</contributor.author>
<contributor.author>Lam, B</contributor.author>
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<description.abstract>BACKGROUND: Smokers with silicosis are at increased risk of lung cancer. OBJECTIVE: To evaluate the feasibility of using auto-fluorescence bronchoscopy after sputum examination for early detection of large airway lung cancer and factors associated with the presence of cancerous and prec ancerous lesions among smokers with silicosis. METHODS: Subjects at the pneumoconiosis clinic were recruited if they fulfilled the following criteria: 1) age &#8805;40 years, 2) smoking history of &#8805;20 pack-years and 3) confirmed diagnosis of silicosis. Sputum specimens were collected for cytology/cytometry examination and autofluorescence bronchoscopy was performed in subjects with an abnormal sputum result. RESULTS: A total of 48 subjects were recruited during the study period. The mean age and smoking history were respectively 63 &#177; 10 years and 51 &#177; 30 pack-years. Intraepithelial lung cancers and pre-neoplastic lesions (squamous metaplasia or above) were detected in respectively 2 (4.2%) and 14 (29.2%) subjects. The proportions of current smokers (75.0% vs. 40.6%, P = 0.03) and asbestos exposure (37.5% vs. 9.4%, P = 0.04) were significantly higher in subjects with the above lesions compared with those without. CONCLUSIONS: Sputum examination followed by auto-fluorescence bronchoscopy may be a useful way of identifying cancerous/pre-cancerous lesions among silicotic smokers. Current smoking and asbestos exposure were associated with these lesions. &#169; 2011 The Union.</description.abstract>
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<subject>Lung cancer</subject>
<subject>Silicosis</subject>
<subject.mesh>Asbestos - toxicity</subject.mesh>
<subject.mesh>Bronchoscopy - methods</subject.mesh>
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Author Affiliations
  1. Centro Hospitalar Conde de Sa&amp;#x0303;o Janua&amp;#x0301;rio
  2. The University of Hong Kong
  3. Daping Hospital, the Third Military Medical University