Article: Early detection of central airway lung cancer in smokers with silicosis
| Title | Early detection of central airway lung cancer in smokers with silicosis | ||||
|---|---|---|---|---|---|
| Authors | Lo, AIL1 2 Huang, Y2 3 Lam, SY Cheung, AHK2 Au, R Leung, CC Lam, WK2 Ip, MSM2 ChanYeung, M2 Lam, B2 | ||||
| Keywords | Autofluorescence bronchoscopy Early detection Lung cancer Silicosis | ||||
| Issue Date | 2011 | ||||
| Publisher | International Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html | ||||
| Citation | International Journal Of Tuberculosis And Lung Disease, 2011, v. 15 n. 4, p. 523-527 [How to Cite?] DOI: http://dx.doi.org/10.5588/ijtld.10.0461 | ||||
| Abstract | BACKGROUND: Smokers with silicosis are at increased risk of lung cancer. OBJECTIVE: To evaluate the feasibility of using auto-fluorescence bronchoscopy after sputum examination for early detection of large airway lung cancer and factors associated with the presence of cancerous and prec ancerous lesions among smokers with silicosis. METHODS: Subjects at the pneumoconiosis clinic were recruited if they fulfilled the following criteria: 1) age ≥40 years, 2) smoking history of ≥20 pack-years and 3) confirmed diagnosis of silicosis. Sputum specimens were collected for cytology/cytometry examination and autofluorescence bronchoscopy was performed in subjects with an abnormal sputum result. RESULTS: A total of 48 subjects were recruited during the study period. The mean age and smoking history were respectively 63 ± 10 years and 51 ± 30 pack-years. Intraepithelial lung cancers and pre-neoplastic lesions (squamous metaplasia or above) were detected in respectively 2 (4.2%) and 14 (29.2%) subjects. The proportions of current smokers (75.0% vs. 40.6%, P = 0.03) and asbestos exposure (37.5% vs. 9.4%, P = 0.04) were significantly higher in subjects with the above lesions compared with those without. CONCLUSIONS: Sputum examination followed by auto-fluorescence bronchoscopy may be a useful way of identifying cancerous/pre-cancerous lesions among silicotic smokers. Current smoking and asbestos exposure were associated with these lesions. © 2011 The Union. | ||||
| ISSN | 1027-3719 2011 Impact Factor: 2.731 2011 SCImago Journal Rankings: 0.249 | ||||
| DOI | http://dx.doi.org/10.5588/ijtld.10.0461 | ||||
| ISI Accession Number ID | WOS:000288882300018
Funding Information: The authors thank Shun Tak District Min Yuen Tong for financial support for this study. | ||||
| References | References in Scopus |
| dc.contributor.author | Lo, AIL | ||||
|---|---|---|---|---|---|
| dc.contributor.author | Huang, Y | ||||
| dc.contributor.author | Lam, SY | ||||
| dc.contributor.author | Cheung, AHK | ||||
| dc.contributor.author | Au, R | ||||
| dc.contributor.author | Leung, CC | ||||
| dc.contributor.author | Lam, WK | ||||
| dc.contributor.author | Ip, MSM | ||||
| dc.contributor.author | ChanYeung, M | ||||
| dc.contributor.author | Lam, B | ||||
| dc.date.accessioned | 2011-09-23T05:50:46Z | ||||
| dc.date.available | 2011-09-23T05:50:46Z | ||||
| dc.date.issued | 2011 | ||||
| dc.description.abstract | BACKGROUND: Smokers with silicosis are at increased risk of lung cancer. OBJECTIVE: To evaluate the feasibility of using auto-fluorescence bronchoscopy after sputum examination for early detection of large airway lung cancer and factors associated with the presence of cancerous and prec ancerous lesions among smokers with silicosis. METHODS: Subjects at the pneumoconiosis clinic were recruited if they fulfilled the following criteria: 1) age ≥40 years, 2) smoking history of ≥20 pack-years and 3) confirmed diagnosis of silicosis. Sputum specimens were collected for cytology/cytometry examination and autofluorescence bronchoscopy was performed in subjects with an abnormal sputum result. RESULTS: A total of 48 subjects were recruited during the study period. The mean age and smoking history were respectively 63 ± 10 years and 51 ± 30 pack-years. Intraepithelial lung cancers and pre-neoplastic lesions (squamous metaplasia or above) were detected in respectively 2 (4.2%) and 14 (29.2%) subjects. The proportions of current smokers (75.0% vs. 40.6%, P = 0.03) and asbestos exposure (37.5% vs. 9.4%, P = 0.04) were significantly higher in subjects with the above lesions compared with those without. CONCLUSIONS: Sputum examination followed by auto-fluorescence bronchoscopy may be a useful way of identifying cancerous/pre-cancerous lesions among silicotic smokers. Current smoking and asbestos exposure were associated with these lesions. © 2011 The Union. | ||||
| dc.description.nature | link_to_OA_fulltext | ||||
| dc.identifier.citation | International Journal Of Tuberculosis And Lung Disease, 2011, v. 15 n. 4, p. 523-527 [How to Cite?] DOI: http://dx.doi.org/10.5588/ijtld.10.0461 | ||||
| dc.identifier.citeulike | 9000481 | ||||
| dc.identifier.doi | http://dx.doi.org/10.5588/ijtld.10.0461 | ||||
| dc.identifier.epage | 527 | ||||
| dc.identifier.hkuros | 196578 | ||||
| dc.identifier.isi | WOS:000288882300018
Funding Information: The authors thank Shun Tak District Min Yuen Tong for financial support for this study. | ||||
| dc.identifier.issn | 1027-3719 2011 Impact Factor: 2.731 2011 SCImago Journal Rankings: 0.249 | ||||
| dc.identifier.issue | 4 | ||||
| dc.identifier.pmid | 21396213 | ||||
| dc.identifier.scopus | eid_2-s2.0-79952798181 | ||||
| dc.identifier.spage | 523 | ||||
| dc.identifier.uri | http://hdl.handle.net/10722/139508 | ||||
| dc.identifier.volume | 15 | ||||
| dc.language | eng | ||||
| dc.publisher | International Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html | ||||
| dc.publisher.place | France | ||||
| dc.relation.ispartof | International Journal of Tuberculosis and Lung Disease | ||||
| dc.relation.references | References in Scopus | ||||
| dc.rights | International Journal of Tuberculosis and Lung Disease. Copyright © International Union against Tuberculosis and Lung Disease. | ||||
| dc.subject.mesh | Asbestos - toxicity | ||||
| dc.subject.mesh | Bronchoscopy - methods | ||||
| dc.subject.mesh | Lung Neoplasms - diagnosis - etiology - pathology | ||||
| dc.subject.mesh | Silicosis - complications | ||||
| dc.subject.mesh | Smoking - adverse effects | ||||
| dc.subject | Autofluorescence bronchoscopy | ||||
| dc.subject | Early detection | ||||
| dc.subject | Lung cancer | ||||
| dc.subject | Silicosis | ||||
| dc.title | Early detection of central airway lung cancer in smokers with silicosis | ||||
| dc.type | Article |
Author Affiliations
- Centro Hospitalar Conde de São Januário
- The University of Hong Kong
- Daping Hospital, the Third Military Medical University