File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Early detection of central airway lung cancer in smokers with silicosis

TitleEarly detection of central airway lung cancer in smokers with silicosis
Authors
KeywordsAutofluorescence bronchoscopy
Early detection
Lung cancer
Silicosis
Issue Date2011
PublisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.html
Citation
International Journal Of Tuberculosis And Lung Disease, 2011, v. 15 n. 4, p. 523-527 How to Cite?
AbstractBACKGROUND: Smokers with silicosis are at increased risk of lung cancer. OBJECTIVE: To evaluate the feasibility of using auto-fluorescence bronchoscopy after sputum examination for early detection of large airway lung cancer and factors associated with the presence of cancerous and prec ancerous lesions among smokers with silicosis. METHODS: Subjects at the pneumoconiosis clinic were recruited if they fulfilled the following criteria: 1) age ≥40 years, 2) smoking history of ≥20 pack-years and 3) confirmed diagnosis of silicosis. Sputum specimens were collected for cytology/cytometry examination and autofluorescence bronchoscopy was performed in subjects with an abnormal sputum result. RESULTS: A total of 48 subjects were recruited during the study period. The mean age and smoking history were respectively 63 ± 10 years and 51 ± 30 pack-years. Intraepithelial lung cancers and pre-neoplastic lesions (squamous metaplasia or above) were detected in respectively 2 (4.2%) and 14 (29.2%) subjects. The proportions of current smokers (75.0% vs. 40.6%, P = 0.03) and asbestos exposure (37.5% vs. 9.4%, P = 0.04) were significantly higher in subjects with the above lesions compared with those without. CONCLUSIONS: Sputum examination followed by auto-fluorescence bronchoscopy may be a useful way of identifying cancerous/pre-cancerous lesions among silicotic smokers. Current smoking and asbestos exposure were associated with these lesions. © 2011 The Union.
Persistent Identifierhttp://hdl.handle.net/10722/139508
ISSN
2014 Impact Factor: 2.315
2014 SCImago Journal Rankings: 1.229
ISI Accession Number ID
Funding AgencyGrant Number
Shun Tak District Min Yuen Tong
Funding Information:

The authors thank Shun Tak District Min Yuen Tong for financial support for this study.

References

 

DC FieldValueLanguage
dc.contributor.authorLo, AILen_HK
dc.contributor.authorHuang, Yen_HK
dc.contributor.authorLam, SYen_HK
dc.contributor.authorCheung, AHKen_HK
dc.contributor.authorAu, Ren_HK
dc.contributor.authorLeung, CCen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorChanYeung, Men_HK
dc.contributor.authorLam, Ben_HK
dc.date.accessioned2011-09-23T05:50:46Z-
dc.date.available2011-09-23T05:50:46Z-
dc.date.issued2011en_HK
dc.identifier.citationInternational Journal Of Tuberculosis And Lung Disease, 2011, v. 15 n. 4, p. 523-527en_HK
dc.identifier.issn1027-3719en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139508-
dc.description.abstractBACKGROUND: Smokers with silicosis are at increased risk of lung cancer. OBJECTIVE: To evaluate the feasibility of using auto-fluorescence bronchoscopy after sputum examination for early detection of large airway lung cancer and factors associated with the presence of cancerous and prec ancerous lesions among smokers with silicosis. METHODS: Subjects at the pneumoconiosis clinic were recruited if they fulfilled the following criteria: 1) age ≥40 years, 2) smoking history of ≥20 pack-years and 3) confirmed diagnosis of silicosis. Sputum specimens were collected for cytology/cytometry examination and autofluorescence bronchoscopy was performed in subjects with an abnormal sputum result. RESULTS: A total of 48 subjects were recruited during the study period. The mean age and smoking history were respectively 63 ± 10 years and 51 ± 30 pack-years. Intraepithelial lung cancers and pre-neoplastic lesions (squamous metaplasia or above) were detected in respectively 2 (4.2%) and 14 (29.2%) subjects. The proportions of current smokers (75.0% vs. 40.6%, P = 0.03) and asbestos exposure (37.5% vs. 9.4%, P = 0.04) were significantly higher in subjects with the above lesions compared with those without. CONCLUSIONS: Sputum examination followed by auto-fluorescence bronchoscopy may be a useful way of identifying cancerous/pre-cancerous lesions among silicotic smokers. Current smoking and asbestos exposure were associated with these lesions. © 2011 The Union.en_HK
dc.languageengen_US
dc.publisherInternational Union against Tuberculosis and Lung Disease. The Journal's web site is located at http://www.theunion.org/about-the-journal/about-the-journal.htmlen_HK
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Diseaseen_HK
dc.rightsInternational Journal of Tuberculosis and Lung Disease. Copyright © International Union against Tuberculosis and Lung Disease.-
dc.subjectAutofluorescence bronchoscopyen_HK
dc.subjectEarly detectionen_HK
dc.subjectLung canceren_HK
dc.subjectSilicosisen_HK
dc.subject.meshAsbestos - toxicity-
dc.subject.meshBronchoscopy - methods-
dc.subject.meshLung Neoplasms - diagnosis - etiology - pathology-
dc.subject.meshSilicosis - complications-
dc.subject.meshSmoking - adverse effects-
dc.titleEarly detection of central airway lung cancer in smokers with silicosisen_HK
dc.typeArticleen_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.5588/ijtld.10.0461en_HK
dc.identifier.pmid21396213en_HK
dc.identifier.scopuseid_2-s2.0-79952798181en_HK
dc.identifier.hkuros196578en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952798181&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue4en_HK
dc.identifier.spage523en_HK
dc.identifier.epage527en_HK
dc.identifier.isiWOS:000288882300018-
dc.publisher.placeFranceen_HK
dc.identifier.scopusauthoridLo, AIL=31767490300en_HK
dc.identifier.scopusauthoridHuang, Y=42961647700en_HK
dc.identifier.scopusauthoridLam, SY=7402279555en_HK
dc.identifier.scopusauthoridCheung, AHK=12795914100en_HK
dc.identifier.scopusauthoridAu, R=42961042200en_HK
dc.identifier.scopusauthoridLeung, CC=7402612644en_HK
dc.identifier.scopusauthoridLam, WK=35934675100en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridChanYeung, M=54790582200en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.citeulike9000481-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats