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Article: Changes in the FEV1/FVC ratio during childhood and adolescence: An intercontinental study

TitleChanges in the FEV1/FVC ratio during childhood and adolescence: An intercontinental study
Authors
KeywordsEthnicity
Growth and development
Lung volume measurements
Sitting height
Thorax
Issue Date2010
PublisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.com
Citation
European Respiratory Journal, 2010, v. 36 n. 6, p. 1391-1399 How to Cite?
AbstractIn children, the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) is reportedly constant or falls linearly with age, whereas the ratio of residual volume (RV) to total lung capacity (TLC) remains constant. This seems counter-intuitive given the changes in airway properties, body proportions, thoracic shape and respiratory muscle function that occur during growth. The age dependence of lung volumes, FEV1/FVC and RV/TLC were studied in children worldwide. Spirometric data were available for 22,412 healthy youths (51.4% male) aged 4-20 yrs from 15 centres, and RV and TLC data for 2,253 youths (56.7% male) from four centres; three sets included sitting height (SH). Data were fitted as a function of age, height and SH. In childhood, FVC outgrows TLC and FEV1, leading to falls in FEV1/FVC and RV/TLC; these trends are reversed in adolescence. Taking into account SH materially reduces differences in pulmonary function within and between ethnic groups. The highest FEV1/FVC ratios occur in those shortest for their age. When interpreting lung function test results, the changing pattern in FEV1/FVC and RV/TLC should be considered. Prediction equations for children and adolescents should take into account sex, height, age, ethnic group, and, ideally, also SH. Copyright©ERS 2010.
Persistent Identifierhttp://hdl.handle.net/10722/139506
ISSN
2015 Impact Factor: 8.332
2015 SCImago Journal Rankings: 3.204
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQuanjer, PHen_HK
dc.contributor.authorStanojevic, Sen_HK
dc.contributor.authorStocks, Jen_HK
dc.contributor.authorHall, GLen_HK
dc.contributor.authorPrasad, KVVen_HK
dc.contributor.authorCole, TJen_HK
dc.contributor.authorRosenthal, Men_HK
dc.contributor.authorPerezPadilla, Ren_HK
dc.contributor.authorHankinson, JLen_HK
dc.contributor.authorFalaschetti, Een_HK
dc.contributor.authorGolshan, Men_HK
dc.contributor.authorBrunekreef, Ben_HK
dc.contributor.authorAlRawas, Oen_HK
dc.contributor.authorKühr, Jen_HK
dc.contributor.authorTrabelsi, Yen_HK
dc.contributor.authorIp, MSMen_HK
dc.date.accessioned2011-09-23T05:50:45Z-
dc.date.available2011-09-23T05:50:45Z-
dc.date.issued2010en_HK
dc.identifier.citationEuropean Respiratory Journal, 2010, v. 36 n. 6, p. 1391-1399en_HK
dc.identifier.issn0903-1936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139506-
dc.description.abstractIn children, the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) is reportedly constant or falls linearly with age, whereas the ratio of residual volume (RV) to total lung capacity (TLC) remains constant. This seems counter-intuitive given the changes in airway properties, body proportions, thoracic shape and respiratory muscle function that occur during growth. The age dependence of lung volumes, FEV1/FVC and RV/TLC were studied in children worldwide. Spirometric data were available for 22,412 healthy youths (51.4% male) aged 4-20 yrs from 15 centres, and RV and TLC data for 2,253 youths (56.7% male) from four centres; three sets included sitting height (SH). Data were fitted as a function of age, height and SH. In childhood, FVC outgrows TLC and FEV1, leading to falls in FEV1/FVC and RV/TLC; these trends are reversed in adolescence. Taking into account SH materially reduces differences in pulmonary function within and between ethnic groups. The highest FEV1/FVC ratios occur in those shortest for their age. When interpreting lung function test results, the changing pattern in FEV1/FVC and RV/TLC should be considered. Prediction equations for children and adolescents should take into account sex, height, age, ethnic group, and, ideally, also SH. Copyright©ERS 2010.en_HK
dc.languageengen_US
dc.publisherEuropean Respiratory Society. The Journal's web site is located at http://erj.ersjournals.comen_HK
dc.relation.ispartofEuropean Respiratory Journalen_HK
dc.subjectEthnicityen_HK
dc.subjectGrowth and developmenten_HK
dc.subjectLung volume measurementsen_HK
dc.subjectSitting heighten_HK
dc.subjectThoraxen_HK
dc.titleChanges in the FEV1/FVC ratio during childhood and adolescence: An intercontinental studyen_HK
dc.typeArticleen_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1183/09031936.00164109en_HK
dc.identifier.pmid20351026-
dc.identifier.scopuseid_2-s2.0-78649726419en_HK
dc.identifier.hkuros196575en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78649726419&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1391en_HK
dc.identifier.epage1399en_HK
dc.identifier.isiWOS:000284765600024-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridQuanjer, PH=7005827550en_HK
dc.identifier.scopusauthoridStanojevic, S=22636433100en_HK
dc.identifier.scopusauthoridStocks, J=7102577078en_HK
dc.identifier.scopusauthoridHall, GL=7402065421en_HK
dc.identifier.scopusauthoridPrasad, KVV=7401617638en_HK
dc.identifier.scopusauthoridCole, TJ=7201770477en_HK
dc.identifier.scopusauthoridRosenthal, M=7203061323en_HK
dc.identifier.scopusauthoridPerezPadilla, R=7003513316en_HK
dc.identifier.scopusauthoridHankinson, JL=7004945742en_HK
dc.identifier.scopusauthoridFalaschetti, E=22943472000en_HK
dc.identifier.scopusauthoridGolshan, M=7003635225en_HK
dc.identifier.scopusauthoridBrunekreef, B=7103344174en_HK
dc.identifier.scopusauthoridAlRawas, O=6602863638en_HK
dc.identifier.scopusauthoridKühr, J=7006247719en_HK
dc.identifier.scopusauthoridTrabelsi, Y=7801691502en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK

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