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Article: Proton pump inhibitor and clopidogrel interaction: The case for watchful waiting

TitleProton pump inhibitor and clopidogrel interaction: The case for watchful waiting
Authors
Keywordsclopidogrel
gastro-intestinal bleeding
proton pump inhibitors
Issue Date2010
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 2010, v. 25 n. 8, p. 1342-1347 How to Cite?
AbstractClopidogrel is an integral part of the management of several important vascular diseases. However the medium to long term clinical outcomes are poorer for these patients if they experience gastro-intestinal bleeding, hence patients with risk factors for gastro-intestinal bleeding are frequently prescribed proton pump inhibitors. Conflicting evidence exists as to the existence of an adverse interaction between clopidogrel and proton pump. This review examines the original studies, which suggested the adverse interaction, the subsequent and most recent studies, the pharmaco-dynamics of the two drugs and suggests an algorithm for the use of clopidogrel with proton pump inhibitors. © 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/139503
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTan, VPen_HK
dc.contributor.authorYan, BPen_HK
dc.contributor.authorHunt, RHen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2011-09-23T05:50:43Z-
dc.date.available2011-09-23T05:50:43Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 2010, v. 25 n. 8, p. 1342-1347en_HK
dc.identifier.issn0815-9319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/139503-
dc.description.abstractClopidogrel is an integral part of the management of several important vascular diseases. However the medium to long term clinical outcomes are poorer for these patients if they experience gastro-intestinal bleeding, hence patients with risk factors for gastro-intestinal bleeding are frequently prescribed proton pump inhibitors. Conflicting evidence exists as to the existence of an adverse interaction between clopidogrel and proton pump. This review examines the original studies, which suggested the adverse interaction, the subsequent and most recent studies, the pharmaco-dynamics of the two drugs and suggests an algorithm for the use of clopidogrel with proton pump inhibitors. © 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.en_HK
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_HK
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_HK
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectclopidogrelen_HK
dc.subjectgastro-intestinal bleedingen_HK
dc.subjectproton pump inhibitorsen_HK
dc.subject.meshGastrointestinal Hemorrhage - chemically induced - prevention and control-
dc.subject.meshPlatelet Aggregation - drug effects-
dc.subject.meshPlatelet Aggregation Inhibitors - adverse effects-
dc.subject.meshProton Pump Inhibitors - adverse effects-
dc.subject.meshTiclopidine - adverse effects - analogs and derivatives-
dc.titleProton pump inhibitor and clopidogrel interaction: The case for watchful waitingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0815-9319&volume=25&issue=8&spage=1342&epage=1347&date=2010&atitle=Proton+pump+inhibitor+and+clopidogrel+interaction:+the+case+for+watchful+waiting-
dc.identifier.emailTan, VP:vpytan@hku.hken_HK
dc.identifier.emailWong, BCY:bcywong@hku.hken_HK
dc.identifier.authorityTan, VP=rp01458en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1440-1746.2010.06366.xen_HK
dc.identifier.pmid20659222-
dc.identifier.scopuseid_2-s2.0-77954919593en_HK
dc.identifier.hkuros196572en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954919593&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1342en_HK
dc.identifier.epage1347en_HK
dc.identifier.isiWOS:000280199000005-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridTan, VP=24449627600en_HK
dc.identifier.scopusauthoridYan, BP=7201858670en_HK
dc.identifier.scopusauthoridHunt, RH=7401608004en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK
dc.identifier.citeulike7601672-

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